Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tetsuya Ezawa"'
Autor:
Masaya Adachi, Hiroyuki Koshino, Mai Akakabe, Tetsuya Ezawa, Mikiko Sodeoka, Daisuke Hashizume, Yoshihiro Sohtome
Publikováno v:
Journal of the American Chemical Society. 143:9094-9104
Reaction design in asymmetric catalysis has traditionally been predicated on a structurally robust scaffold in both substrates and catalysts, to reduce the number of possible diastereomeric transition states. Herein, we present the stereochemical dyn
Autor:
Yoshihiro Sohtome, Mikiko Sodeoka, Rikako Ohnishi, Daiki Hojo, Mai Akakabe, Tetsuya Ezawa, Masumi Sugawara, Daisuke Hashizume, Miki Sawamura
Publikováno v:
ACS Catalysis. 10:12770-12782
Oxidative cross-coupling is a powerful synthetic strategy for forming a carbon–carbon bond from two nucleophiles having C–H bonds. However, controlling the coupling selectivity (homo- vs cross-coup...
Autor:
Masumi Sugawara, Hiroyuki Koshino, Yoshihiro Sohtome, Mikiko Sodeoka, Tetsuya Ezawa, Mai Akakabe, Rikako Ohnishi
Publikováno v:
Asian Journal of Organic Chemistry. 8:1017-1023
Publikováno v:
Chemicalpharmaceutical bulletin. 68(9)
We have developed a catalytic aerobic oxidative dimerization reaction of benzofuranones using a Pd(II)-µ-hydroxo complex. Radical-radical cross-coupling of the resulting dimers with azo compounds enabled the one-pot synthesis of structurally congest
Publikováno v:
Tetrahedron: Asymmetry. 28:1690-1699
Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of va
Publikováno v:
Bulletin of the Chemical Society of Japan. 90:689-696
The coupling reactions of 3-phenylpropanoic acid and N-carboxybenzyl α-amino acids with unprotected α-amino acids containing hydrophilic side chains such as aliphatic alcohol, aromatic alcohol, thi...
Publikováno v:
Tetrahedron: Asymmetry. 28:266-281
We have achieved a convenient enantioselective synthesis of memantine analogues containing a chiral cyclopropane skeleton as a sigma-1 receptor agonist in 19–40% overall chemical yields from the corresponding 2-arylbut-2-ene-1,4-diols with moderate
Publikováno v:
Tetrahedron: Asymmetry. 28:75-83
Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine
Autor:
Masashi Kawasaki, Taisuke Harada, Tetsuya Ezawa, Yuya Kawashima, Takuya Noguchi, Nobuyuki Imai, Masayuki Kirihara
Publikováno v:
Bulletin of the Chemical Society of Japan. 89:257-267
3-Substituted (Z)-4-hydroxybut-2-en-1-yl acylates were regioselectively obtained in 2–98% yields by acylations of the corresponding 2-substituted (Z)-but-2-ene-1,4-diols with 10 equiv of vinyl acyl...
Publikováno v:
Tetrahedron Letters. 57:668-671
The catalytic enantioselective Simmons–Smith reaction of (Z)-4-tert-butyldiphenylsiloxy-3-phenylbut-2-en-1-ol using l -phenylalanine-derived disulfonamide afforded (+)-cis-4-tert-butyldiphenylsiloxy-2,3-methano-3-phenylbutan-1-ol in quantitative yi