Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Tetsuya, Okajima"'
Publikováno v:
Molecules, Vol 29, Iss 5, p 1031 (2024)
Epidermal growth factor (EGF) repeats are present in various proteins and form well-defined structures with three disulfide bonds. One representative protein is the Notch receptor. Each EGF repeat contains unique atypical O-linked glycans, such as O-
Externí odkaz:
https://doaj.org/article/1435a97e59bc4a2cba920806c5d96d23
Publikováno v:
Molecules, Vol 27, Iss 6, p 1783 (2022)
Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling lea
Externí odkaz:
https://doaj.org/article/481d303b0f094f7d99f7e6d93a5aa92f
Autor:
Yuji Kondo, Tetsuya Okajima
Publikováno v:
The Journal of Biochemistry. 173:333-335
Dystroglycan (DG), a muscular transmembrane protein, plays a critical role in transducing extracellular matrix-derived signals to the cytoskeleton and provides physical strength to skeletal muscle cell membranes. The extracellular domain of DG, α-DG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c471acbd1678ef0bd63a5673cd1eebe6
https://doi.org/10.1093/jb/mvad003
https://doi.org/10.1093/jb/mvad003
Autor:
Rashu Barua, Kazuyuki Mizuno, Yuko Tashima, Mitsutaka Ogawa, Hideyuki Takeuchi, Ayumu Taguchi, Tetsuya Okajima
Publikováno v:
Molecules, Vol 26, Iss 4, p 882 (2021)
Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression. However, dysregulation of Notch s
Externí odkaz:
https://doaj.org/article/0834f2abbaee4d6f805b924851296d70
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 309 (2021)
The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in developme
Externí odkaz:
https://doaj.org/article/2895bc6495c748fe9656ec63ba3e54cd
Autor:
Yohei Tsukamoto, Mitsutaka Ogawa, Kentarou Yogi, Yuko Tashima, Hideyuki Takeuchi, Tetsuya Okajima
Publikováno v:
Glycobiology. 32:616-628
O-GlcNAc modification of Notch receptors regulates Notch ligand interactions in a manner distinct from other forms of O-glycans on epidermal growth factor (EGF)-like repeats of Notch receptors. Although many proteins, besides Notch receptors, are exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c669adf36b652d2f0c370b1df422cef1
https://doi.org/10.1093/glycob/cwac015
https://doi.org/10.1093/glycob/cwac015
Autor:
Pei-Wen Lo, Tetsuya Okajima
Publikováno v:
Trends in Glycoscience and Glycotechnology. 34:E1-E6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a568729637f669870973865ad5b9dea
https://doi.org/10.4052/tigg.2033.1e
https://doi.org/10.4052/tigg.2033.1e
Autor:
Yusuke Urata, Wataru Saiki, Yohei Tsukamoto, Hiroaki Sago, Hideharu Hibi, Tetsuya Okajima, Hideyuki Takeuchi
Publikováno v:
Cells, Vol 9, Iss 5, p 1220 (2020)
Biochemical and genetic studies have indicated that O-linked glycosylation such as O-glucose (Glc), fucose (Fuc), and N-acetylglucosamine (GlcNAc) is critical for Notch signaling; however, it is not fully understood how O-glycans regulate the Notch r
Externí odkaz:
https://doaj.org/article/6059dd3acfda4ba38cc5ebb8551d2ab9
Autor:
Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Satoko Yamamoto, Kei Kaneko, Yuki Ohkawa, Pu Zhang, Kazunori Hamamura, Nai-Kong V. Cheung, Norihiro Kotani, Koichi Honke, Tetsuya Okajima, Mariko Kambe, Orie Tajima, Keiko Furukawa, Koichi Furukawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 423, p 423 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 423
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 423
International Journal of Molecular Sciences
Gangliosides have been considered to modulate cell signals in the microdomain of the cell membrane, lipid/rafts, or glycolipid-enriched microdomain/rafts (GEM/rafts). In particular, cancer-associated gangliosides were reported to enhance the malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d101c7e495aaab8e86b2b0016b3c7a3
https://www.mdpi.com/1422-0067/23/1/423
https://www.mdpi.com/1422-0067/23/1/423
Publikováno v:
Bio-Protocol, Vol 7, Iss 20 (2017)
This protocol describes how to measure interaction between Notch receptors and their ligands by cell-based assay using Dynabeads. We have used the protocol to determine binding capacity between Notch1-transfected HEK293T cells and ligand-coated Dynab
Externí odkaz:
https://doaj.org/article/fee329c8fad24f3e938a55fa6d92ce30