Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tetsushi Yamagata"'
Autor:
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa
Publikováno v:
eLife, Vol 12 (2023)
Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded by SCN1A and SCN2A genes, respectively, have been reported to be mutually exclusive in most brain regions. In juvenile and adult neocortex, Nav1.1 is predominantly expressed in i
Externí odkaz:
https://doaj.org/article/7469f0ad906948b3991e9403aaccb070
Autor:
Hiroyuki Miyamoto, Tetsuya Tatsukawa, Atsushi Shimohata, Tetsushi Yamagata, Toshimitsu Suzuki, Kenji Amano, Emi Mazaki, Matthieu Raveau, Ikuo Ogiwara, Atsuko Oba-Asaka, Takao K. Hensch, Shigeyoshi Itohara, Kenji Sakimura, Kenta Kobayashi, Kazuto Kobayashi, Kazuhiro Yamakawa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast sp
Externí odkaz:
https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb0
Autor:
Tetsushi Yamagata, Matthieu Raveau, Kenta Kobayashi, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Ikuo Ogiwara, Shigeyoshi Itohara, Takao K. Hensch, Kazuhiro Yamakawa
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104954- (2020)
Dravet syndrome is a severe infantile-onset epileptic encephalopathy which begins with febrile seizures and is caused by heterozygous loss-of-function mutations of the voltage-gated sodium channel gene SCN1A. We designed a CRISPR-based gene therapy f
Externí odkaz:
https://doaj.org/article/5dcdb010a00b4b069893459121de7090
Autor:
Tetsuya Tatsukawa, Ikuo Ogiwara, Tetsushi Yamagata, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa
Publikováno v:
eLife. 12
Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded by SCN1A and SCN2A genes, respectively, have been reported to be mutually exclusive in most brain regions. In juvenile and adult neocortex, Nav1.1 is predominantly expressed in i
Autor:
Tetsuya Tatsukawa, Ikuo Ogiwara, Tetsushi Yamagata, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3666f976ffbe383c3850719a69968d
https://doi.org/10.7554/elife.87495.sa2
https://doi.org/10.7554/elife.87495.sa2
Autor:
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa
Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded bySCN1AandSCN2Agenes respectively, have been reported to be mutually exclusive in most brain regions. In juvenile and adult neocortex, Nav1.1 is predominantly expressed in inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c609c88515ad77e29a3ccb3b447772d5
https://doi.org/10.1101/2021.03.31.437794
https://doi.org/10.1101/2021.03.31.437794
Autor:
Ikuo Ogiwara, Kazuhiro Yamakawa, Hiroyuki Miyamoto, Takao K. Hensch, Matthieu Raveau, Tetsushi Yamagata, Kenta Kobayashi, Tetsuya Tatsukawa, Shigeyoshi Itohara
Publikováno v:
Neurobiology of Disease, Vol 141, Iss, Pp 104954-(2020)
Dravet syndrome is a severe infantile-onset epileptic encephalopathy which begins with febrile seizures and is caused by heterozygous loss-of-function mutations of the voltage-gated sodium channel gene SCN1A. We designed a CRISPR-based gene therapy f
Autor:
Tetsuya Tatsukawa, Kenji Sakimura, Emi Mazaki, Ikuo Ogiwara, Toshimitsu Suzuki, Kenji Amano, Atsuko Oba-Asaka, Hiroyuki Miyamoto, Takao K. Hensch, Tetsushi Yamagata, Matthieu Raveau, Kenta Kobayashi, Atsushi Shimohata, Shigeyoshi Itohara, Kazuhiro Yamakawa, Kazuto Kobayashi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiate
Autor:
Kazuhiro Yamakawa, Ikuo Ogiwara, Mauricio Montal, Shigeyoshi Itohara, Tojo Nakayama, Sara J. Ernst, Hideyuki Ohtani, Yuchio Yanagawa, Emi Mazaki, Dezhi Cao, Tetsuya Tatsukawa, Eriko Miura, Michisuke Yuzaki, Yushi Inoue, Hiroyuki Miyamoto, Nafiseh Atapour, Takao K. Hensch, Jeffrey L. Noebels, Tetsushi Yamagata
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-16 (2018)
Mutations in the SCN2A gene encoding a voltage-gated sodium channel Nav1.2 are associated with epilepsies, intellectual disability, and autism. SCN2A gain-of-function mutations cause early-onset severe epilepsies, while loss-of-function mutations cau
Autor:
William M. Pardridge, Manuel L. Penichet, Tetsushi Yamagata, Eain M. Cornford, Kazuhiro Yamakawa, Marcia E. Cornford, Shigeyo Hyman, Jennifer Rhee, Gabriela Chytrova, Toshimitsu Suzuki
Publikováno v:
Journal of Drug Targeting. 24:58-67
Research was undertaken to establish transplacental delivery of active genes to fetal brain by a non-viral vector, antibody-specific targeted therapeutic procedure. PEGylated immunoliposomes (PILs) containing firefly luciferase DNA under the influenc