Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Tetsushi Nakao"'
Autor:
Zhi Yu, Trevor P. Fidler, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin, Taralynn Mack, Abhishek Niroula, J. Brett Heimlich, Seyedeh M. Zekavat, Christopher J. Gibson, Gabriel K. Griffin, Yuxuan Wang, Gina M. Peloso, Nancy Heard-Costa, Daniel Levy, Ramachandran S. Vasan, François Aguet, Kristin G. Ardlie, Kent D. Taylor, Stephen S. Rich, Jerome I. Rotter, Peter Libby, Siddhartha Jaiswal, Benjamin L. Ebert, Alexander G. Bick, Alan R. Tall, Pradeep Natarajan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 42
Externí odkaz:
https://doaj.org/article/4b73ca94ea51466da314839f5b8ac232
Autor:
Art Schuermans, Tetsushi Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Md Mesbah Uddin, Sara Haidermota, Whitney Hornsby, Adam J. Lewandowski, Alexander G. Bick, Abhishek Niroula, Siddhartha Jaiswal, Benjamin L. Ebert, Pradeep Natarajan, Michael C. Honigberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age‐related clonal expansion of hematopoietic cells with preleuke
Externí odkaz:
https://doaj.org/article/0d0b797babec43fb8c439a6fafd33620
Autor:
Tetsushi Nakao, Peter Libby
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
The cytokine IL-6 has well-known proinflammatory roles in aging and ischemic heart disease. In this issue of the JCI, Alter and colleagues used mouse experiments and human tissue to investigate the source of IL-6 following myocardial infarction. The
Externí odkaz:
https://doaj.org/article/f3f4ba9f0b5947ba8112524709a09d49
Autor:
M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET
Externí odkaz:
https://doaj.org/article/c22e81f057bd44ef857ef1b82f628c5a
Autor:
Tomohiro Yamasaki, Takahiro Horie, Satoshi Koyama, Tetsushi Nakao, Osamu Baba, Masahiro Kimura, Naoya Sowa, Kazuhisa Sakamoto, Kazuhiro Yamazaki, Satoshi Obika, Yuuya Kasahara, Jun Kotera, Kozo Oka, Ryo Fujita, Takashi Sasaki, Akihiro Takemiya, Koji Hasegawa, Kenji Minatoya, Takeshi Kimura, Koh Ono
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Abdominal aortic aneurysm (AAA) is a lethal disease, but no beneficial therapeutic agents have been established to date. Previously, we found that AAA formation is suppressed in microRNA (miR)-33-deficient mice compared with wild-type mice.
Externí odkaz:
https://doaj.org/article/445284dacf4046649dd1ebec40553f4f
Autor:
Michael G. Levin, Tetsushi Nakao, Seyedeh M. Zekavat, Satoshi Koyama, Alexander G. Bick, Abhishek Niroula, Benjamin Ebert, Scott M. Damrauer, Pradeep Natarajan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic
Externí odkaz:
https://doaj.org/article/db5e4f08879c4e459bfdd008e1ec4669
Autor:
Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve t
Externí odkaz:
https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f
Autor:
Yuya Ide, MD, Takahiro Horie, MD, PhD, Naritatsu Saito, MD, PhD, Shin Watanabe, MD, PhD, Chiharu Otani, MD, Yui Miyasaka, BSc, Yasuhide Kuwabara, MD, PhD, Tomohiro Nishino, MD, PhD, Tetsushi Nakao, MD, PhD, Masataka Nishiga, MD, PhD, Hitoo Nishi, MD, PhD, Yasuhiro Nakashima, MD, PhD, Fumiko Nakazeki, MD, PhD, Satoshi Koyama, MD, PhD, Masahiro Kimura, MD, Shuhei Tsuji, MD, Randolph Ruiz Rodriguez, MD, Sijia Xu, MD, Tomohiro Yamasaki, MD, Toshimitsu Watanabe, MD, Masamichi Yamamoto, PhD, Motoko Yanagita, MD, PhD, Takeshi Kimura, MD, PhD, Akira Kakizuka, MD, PhD, Koh Ono, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
Summary: No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyo
Externí odkaz:
https://doaj.org/article/d66cbcb274f6484fb40460d224a0132a
Autor:
Satoshi Koyama, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Naoya Sowa, Yui Miyasaka, Yasuhide Kuwabara, Tetsushi Nakao, Masataka Nishiga, Hitoo Nishi, Yasuhiro Nakashima, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Sijia Xu, Tomohiro Yamasaki, Chiharu Otani, Toshimitsu Watanabe, Tomoyuki Nakamura, Koji Hasegawa, Takeshi Kimura, Koh Ono
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background MicroRNA (miR)‐33 targets cholesterol transporter ATP‐binding cassette protein A1 and other antiatherogenic targets and contributes to atherogenic progression. Its inhibition or deletion is known to result in the amelioration of athero
Externí odkaz:
https://doaj.org/article/69648184ded84dff81452fbc1f678cd7
Autor:
Masayasu Izuhara, Yasuhide Kuwabara, Naritatsu Saito, Erika Yamamoto, Daihiko Hakuno, Yasuhiro Nakashima, Takahiro Horie, Osamu Baba, Masataka Nishiga, Tetsushi Nakao, Tomohiro Nishino, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Takeshi Kimura, Koh Ono
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172798 (2017)
Despite recent progress with drug-eluting stents, restenosis and thrombosis after endovascular intervention are still major limitations in the treatment of cardiovascular diseases. These problems are possibly caused by inappropriate inhibition of neo
Externí odkaz:
https://doaj.org/article/f1935171674a4d458b8d28de151e7443