Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tetsuro Orita"'
Autor:
Kiyotaka Nakano, Yasuko Kinoshita, Izumi Sugo, Kiyoshi Habu, Takahiro Ishiguro, Masayuki Tsuchiya, Hiroko Konishi, Tetsuro Orita, Masamichi Sugimoto, Hisafumi Yamada-Okabe, Megumi Tanaka, Kunihiro Hattori, Tomoyuki Igawa, Hiroyuki Tsunoda
Publikováno v:
Anti-Cancer Drugs. 21:907-916
Glypican 3 (GPC3), a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, is expressed in a majority of hepatocellular carcinoma tissues. The murine monoclonal antibody GC33 that specifically binds to the COOH-terminal part of GPC3 cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235480c3a1bb15965f46e3b17887b540
https://doi.org/10.1097/cad.0b013e32833f5d68
https://doi.org/10.1097/cad.0b013e32833f5d68
Autor:
Jun-ichi Nezu, Hisafumi Yamada-Okabe, Hiroyuki Aburatani, Tatsuhiko Kodama, Kiyotaka Nakano, Takao Hamakubo, Masamichi Sugimoto, Takahiro Ishiguro, Koh Furugaki, Iwao Ohizumi, Yasuko Kinoshita, Tetsuro Orita, Takeshi Yoshino, Masayuki Tsuchiya
Publikováno v:
Biochemical and Biophysical Research Communications. 378:279-284
Glypican 3 (GPC3), a GPI-anchored heparan sulfate proteoglycan, is expressed in the majority of hepatocellular carcinoma (HCC) tissues. Using MRL/lpr mice, we successfully generated a series of anti-GPC3 monoclonal antibodies (mAbs). GPC3 was partial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d323811ffd6361debe434bdafb205e
https://doi.org/10.1016/j.bbrc.2008.11.033
https://doi.org/10.1016/j.bbrc.2008.11.033
A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
Autor:
Yuichi Hirata, Akihisa Kaneko, Kiyotaka Nakano, Takashi Yoshikubo, Hirofumi Sakumoto, Tetsuro Orita, Hiroyuki Tsunoda, Toshihiko Ohtomo, Masahiko Nanami, Naohiro Yabuta, Eiji Kumagai, Kouichiro Ono, Takeshi Yoshino, Masayuki Tsuchiya, Mikiyoshi Saito, Jun-ichi Nezu
Publikováno v:
Blood. 105:562-566
Antibodies have brought valuable therapeutics in the clinical treatment of various diseases without serious adverse effects through their intrinsic features such as specific binding to the target antigen with high affinity, clinical safety as serum p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b359f478492a1e2f9c18f8109d96f63
https://doi.org/10.1182/blood-2004-04-1482
https://doi.org/10.1182/blood-2004-04-1482
Autor:
Hisafumi Okabe, Shuji Ozaki, Yumiko Azuma, Tetsuro Orita, Yuichi Hirata, Masayuki Tsuchiya, Yasuko Kinoshita, Naoki Kimura, Masamichi Sugimoto, Toshio Matsumoto, Takahiro Ishiguro, Shigeto Kawai, Masahiro Abe
Publikováno v:
Biochemical and Biophysical Research Communications. 325:1201-1209
A mouse monoclonal antibody (2D7 mAb), which specifically bound to the alpha2 domain of HLA class I, rapidly induces cell aggregation accompanied by weak cytotoxicity against ARH-77 cells, suggesting that 2D7 mAb had a potential for agonist antibody.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df41a60cf762628ecc04199b33cb4d9
https://doi.org/10.1016/j.bbrc.2004.10.163
https://doi.org/10.1016/j.bbrc.2004.10.163
Publikováno v:
Journal of Biological Chemistry. 272:23216-23223
The expression of the myeloperoxidase (MPO) gene is restricted to cells of the myeloid cell lineage and is induced by granulocyte colony-stimulating factor (G-CSF). In this study, a series of deletion mutations was introduced in the promoter of the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ac9dc3a6855e31ad8b860ead9976a0
https://doi.org/10.1074/jbc.272.37.23216
https://doi.org/10.1074/jbc.272.37.23216
Autor:
Hisakazu Yamagishi, Yoshizumi Matsukawa, Takashi Tokino, Takahiro Oka, Yusuke Okuyama, Takakazu Mizuno, Yoshihiro Sowa, Tsuyoshi Fujita, Naoko Ohtani-Fujita, Katsunori Nakano, Toshiyuki Sakai, Hitoshi Nomura, Takeshi Yoshino, Tetsuro Orita
Publikováno v:
Journal of Biological Chemistry. 272:22199-22206
Butyrate is a well known colonic luminal short chain fatty acid, which arrests cell growth and induces differentiation in various cell types. We examined the effect of butyrate on the expression of WAF1/Cip1, a potent inhibitor of cyclin-dependent ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c023837b6ee99f222d19e7be252e2c
https://doi.org/10.1074/jbc.272.35.22199
https://doi.org/10.1074/jbc.272.35.22199
Autor:
Keiko Esaki, Masakazu Hasegawa, Hitoshi Kuboniwa, Tetsuro Orita, Masayoshi Oh-eda, Norimichi Ochi
Publikováno v:
The Journal of Biochemistry. 115:345-350
A glycosylated form of human interleukin 6 (hIL-6) has been produced in Chinese hamster ovary (CHO) cells transfected with a cDNA clone for human IL-6. Recombinant hIL-6 was purified from a culture supernatant of the transfected CHO cells, and used f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b03ec582d4f07c4d5fb0665f42620d
https://doi.org/10.1093/oxfordjournals.jbchem.a124340
https://doi.org/10.1093/oxfordjournals.jbchem.a124340
Autor:
Tetsuro Orita, Masayoshi Ono, Masakazu Hasegawa, Taira Maekawa, Masahiko Tamura, Hitoshi Nomura, Masayoshi Oh-eda, Tatsuo Abe
Publikováno v:
Leukemia Research. 17:593-600
We have investigated the effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administration on the leukemogenic potential of L-103 murine leukemic cells. Leukemogenic potential was assessed by comparing the regression lines dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8044ec03c11149ef6c725025da1501ff
https://doi.org/10.1016/0145-2126(93)90090-8
https://doi.org/10.1016/0145-2126(93)90090-8
Autor:
Akiko Koga, Tomoyuki Igawa, Yasufumi Kikuchi, Yasuo Sekimori, Hiroyuki Tsunoda, Megumi Tanaka, Masayuki Tsuchiya, Tetsuro Orita, Kunihiro Hattori, Yoshinori Aso, Maki Yoshida
Publikováno v:
Protein engineering, designselection : PEDS. 23(8)
Thrombopoietin receptor agonist humanized VB22B single-chain diabody (hVB22B (scFv)(2)) was found to be expressed as a mixture of two conformational isomers, a single-chain diabody form and a bivalent scFv form, which had different V(H)/V(L) (variabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a110f9bcd18b60dd793dd619aa702e5d
https://pubmed.ncbi.nlm.nih.gov/20576629
https://pubmed.ncbi.nlm.nih.gov/20576629
Autor:
Masakazu Hasegawa, Yuichi Hirata, Tetsuro Orita, Tetsuo Kojima, Norimichi Ochi, Kikuo Tomonoh
Publikováno v:
European Journal of Biochemistry. 210:9-12
Recombinant human interleukin-6 (IL-6), expressed in Chinese hamster ovary cells, has heterogeneous N-termini of Ala1 and Val3, as does naturally occurring IL-6. This heterogeneity is thought to be caused by difficulty in cleavage of the signal seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d87b15309e2c8af22ccc0b2479fc8d8
https://doi.org/10.1111/j.1432-1033.1992.tb17384.x
https://doi.org/10.1111/j.1432-1033.1992.tb17384.x