Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Tetsuro Haruta"'
Autor:
Tetsuro Haruta, Junko Kawahara, Kazuyuki Hiratani, Tatsuhito Uno, Isao Usui, Yukiko Kanatani, Minoru Iwata, Atsuko Takano, Kazuyuki Tobe, Masashi Kobayashi
Publikováno v:
The Open Diabetes Journal. 3:14-21
IRS-1 is a major substrate for insulin receptor tyrosine kinase. It is reported that intracellular translocation of serine-phosphorylated IRS-1 from low density microsome (LDM) fraction to cytosol attenuates its ability to transmit insulin signaling
Autor:
Ken Ishizuka, Shiho Fujisaka, Masaharu Urakaze, Tetsuji Naka, Tadamitsu Kishimoto, Tetsuro Haruta, Yukiko Kanatani, Masashi Kobayashi, Isao Usui, Agussalim Bukhari
Publikováno v:
Diabetes. 56:795-803
Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine s
Autor:
Jianying He, Tetsuro Haruta, Isao Usui, Ken Ishizuka, Masashi Kobayashi, Agussalim Bukhari, Yukiko Kanatani, Minoru Iwata, Kazuyuki Hiratani, Toshiyasu Sasaoka
Publikováno v:
Molecular Endocrinology. 20:114-124
Proinflammatory cytokines are recently reported to inhibit insulin signaling causing insulin resistance. IL-1α is also one of the proinflammatory cytokines; however, it has not been clarified whether IL-1α may also cause insulin resistance. Here, w
Autor:
Junko Kawahara, Isao Usui, Tetsuro Haruta, Akihiro Tani, Kazuyuki Hiratani, Masashi Kobayashi
Publikováno v:
Biochemical and Biophysical Research Communications. 335:836-842
In 3T3-L1 adipocytes, insulin or anisomycin stimulated phosphorylation of IRS-1 at Ser(307) and Ser(636/639), both of which were partially reduced by the mTOR inhibitor, rapamycin, or the JNK inhibitor, SP600125, and were further inhibited by a combi
Autor:
Junko Kawahara, Tatsuhito Uno, Isao Usui, Minoru Iwata, Atsuko Takano, Tetsuro Haruta, Masashi Kobayashi
Publikováno v:
Molecular and Cellular Biology. 21:5050-5062
A pathway sensitive to rapamycin, a selective inhibitor of mammalian target of rapamycin (mTOR), down-regulates effects of insulin such as activation of Akt (protein kinase B) via proteasomal degradation of insulin receptor substrate 1 (IRS-1). We re
Autor:
Tetsuro Haruta, Junko Kawahara, Tatsuhito Uno, Eiichi Ueno, Isao Usui, Toshiyasu Sasaoka, Minoru Iwata, Masashi Kobayashi, Atsuko Takano
Publikováno v:
Diabetes. 50:1891-1900
Growth hormone (GH) is well known to induce in vivo insulin resistance. However, the molecular mechanism of GH-induced cellular insulin resistance is largely unknown. In this study, we demonstrated that chronic GH treatment of differentiated 3T3-L1 a
Autor:
Shihou Murakami, Tomoichiro Asano, Tetsuro Haruta, Manabu Ishiki, Hajime Ishihara, Hiroyuki Hori, Masashi Kobayashi, Wataru Ogawa, Tsutomu Wada, Makoto Funaki, Toshiyasu Sasaoka
Publikováno v:
Molecular and Cellular Biology. 21:1633-1646
Insulin binding to the extracellular α subunit of the insulin receptor activates the intrinsic tyrosine kinase activity of the intracellular β subunit. The activated insulin receptor phosphorylates the insulin receptor substrate (IRS) family of pro
Autor:
Masashi Kobayashi, Tetsuro Haruta, Toshiyasu Sasaoka, Junko Kawahara, Tatsuhito Uno, Isao Usui, Eiichi Ueno, Minoru Iwata, Atsuko Takano
Publikováno v:
Biochemical and Biophysical Research Communications. 275:115-120
In the early phase of adipocyte differentiation, transient increase of DNA synthesis, called clonal expansion, and transient hyperphosphorylation of retinoblastoma protein (Rb) are observed. We investigated the role of these phenomena in insulin-indu
Autor:
Junko Kawahara, Tatsuhito Uno, Prem M. Sharma, Tetsuro Haruta, Katsuya Egawa, Atsuko Takano, Masashi Kobayashi, Jerrold M. Olefsky
Publikováno v:
Molecular Endocrinology. 14:783-794
Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology 2 domain containing signaling molecules that mediate many of the pleiotropic actions of insulin. Insulin stimulation elic
Autor:
Tetsuro Haruta, Hajime Ishihara, Manabu Ishiki, Tsutomu Wada, Masashi Kobayashi, Toshiyasu Sasaoka, Hiroyuki Hori
Publikováno v:
Endocrinology. 140:4585-4594
To examine the role of SHIP in insulin-induced mitogenic signaling, we used a truncated SHIP lacking the SH2 domain (ΔSH2-SHIP) and a Y917/1020F-SHIP (2F-SHIP) in which two tyrosines contributing to Shc binding were mutated to phenylalanine. Wild-ty