Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tetsuo Ohnuki"'
Publikováno v:
Biochemical and Biophysical Research Communications. 334:987-995
We have previously identified a Galpha(i/o)-protein-coupled receptor (TG1019/OXE) using 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) as its ligand. We investigated signal transduction from TG1019 following stimulation with 5-oxo-ETE and role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a4bca4d9b0db7c557d53870fb75e5
https://doi.org/10.1016/j.bbrc.2005.06.191
https://doi.org/10.1016/j.bbrc.2005.06.191
Autor:
Hiroyuki Hoshino, Kimio Kawano, Toru Okuda, Maki Nishio, Noboru Kishi, Tetsuo Ohnuki, Masaaki Sakurai, Jun Kohno
Publikováno v:
The Journal of Antibiotics. 56:787-791
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351e6a9d2a50764e5ec2e6903a3f1d30
https://doi.org/10.7164/antibiotics.56.787
https://doi.org/10.7164/antibiotics.56.787
Publikováno v:
The Journal of Antibiotics. 56:513-519
A novel inhibitor of STAT6 activation, named as TMC-264 (1), was discovered from the fermentation broth of Phoma sp. TC 1674. Based on spectroscopic analyses, TMC-264 was found to be a novel tricyclic polyketide with chloro-1H-dibenzo[b,d]pyran-4,6-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c1da63195717a138db008c204ecba6
https://doi.org/10.7164/antibiotics.56.513
https://doi.org/10.7164/antibiotics.56.513
Autor:
Saburo Komatsubara, Tetsuo Ohnuki, Ryo Shimizu, Masataka Kuroda, Kazuya Nakao, Yutaka Koguchi, Jun Kohno, Maki Nishio
Publikováno v:
The Journal of Organic Chemistry. 65:990-995
Four novel proteasome inhibitors, TMC-95A-D (1-4) have been isolated from the fermentation broth of Apiospora montagnei Sacc. TC 1093, isolated from a soil sample. All of the molecular formulas of 1-4 were established as C(33)H(38)N(6)O(10) by high-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f4d4dd1c496b94956928d3ba60733a
https://doi.org/10.1021/jo991375+
https://doi.org/10.1021/jo991375+
Autor:
Toru Okuda, Kohei Takahashi, Jun Kohno, Tetsuo Ohnuki, Yutaka Koguchi, Saburo Komatsubara, Maki Nishio
Publikováno v:
The Journal of Antibiotics. 53:105-109
In our course of screening for novel proteasome inhibitors, TMC-95A and its diastereomers, TMC-95B to D, were isolated from the fermentation broth of Apiospora montagnei Sacc. TC 1093. TMC-95A inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e9c805884037978530a2acd5ccc7da
https://doi.org/10.7164/antibiotics.53.105
https://doi.org/10.7164/antibiotics.53.105
Publikováno v:
IUBMB Life. 47:587-595
Ansamycin antibiotic, geldanamycin has a unique pharmacological effect to bind to heat shock protein 90 (hsp90) and deplete hsp90 substrates. We investigated the immunopharmacological effects of geldanamycin. Geldanamycin depleted cellular Raf-1 of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7b814be9bd5f5cd8979eacdba0f00b
https://doi.org/10.1080/15216549900201633
https://doi.org/10.1080/15216549900201633
Autor:
Takahisa Sugita, Tetsuo Ohnuki, Takanori Higashijima, Masaki Yamada, Sumiko Tanaka, Chieko Okagaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1537-1540
A series of novel potent inhibitors of dipeptidyl peptidase IV (DPP-IV) has been developed. A brief structure-activity relationship of the inhibitors was investigated. The dipeptide TSL-225, tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d1bf1c7d971cecd0d221ebc34c208
https://doi.org/10.1016/s0960-894x(98)00259-5
https://doi.org/10.1016/s0960-894x(98)00259-5
Autor:
Yutaka Koguchi, Yasuyuki Asai, Noriyuki Yanaka, Tetsuo Ohnuki, Maki Nishio, Shin-Ichi Suzuki, Kenji Omori, Saburo Komatsubara
Publikováno v:
The Journal of Antibiotics. 51:107-111
Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62af072e9d90509be554582627d0262e
https://doi.org/10.7164/antibiotics.51.107
https://doi.org/10.7164/antibiotics.51.107
Autor:
Maki Nishio, Saburo Komatsubara, Tadamasa Date, Takahisa Sugita, Kimio Okamura, Nobuaki Nonaka, Tetsuo Ohnuki, Yasuyuki Asai
Publikováno v:
The Journal of Antibiotics. 50:653-658
New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0aee45871df68531dfdf046c002bfa9
https://doi.org/10.7164/antibiotics.50.653
https://doi.org/10.7164/antibiotics.50.653
Publikováno v:
Organic Letters. 5:1083-1085
[structure: see text] TMC-264 (1), a novel tricyclic heptaketide with a unique chloro-1H-dibenzo[b,d]pyran-4,6-dione skeleton, was discovered from the fungus Phoma sp. TC 1674. The structure was elucidated on the basis of NMR analyses of normal abund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e47b0cb727038b250624e61ac2f38
https://doi.org/10.1021/ol034125v
https://doi.org/10.1021/ol034125v