Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Tetsuo Noda"'
Autor:
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here we treat male STAM (STelic Animal Model) mice, which develop diabetes, NASH and HCC associated with dysbiosis upon low-dos
Externí odkaz:
https://doaj.org/article/00518db0b90f431a9f78d36478f351e5
Autor:
Sumito Saeki, Kohei Kumegawa, Yoko Takahashi, Liying Yang, Tomo Osako, Mahmut Yasen, Kazutaka Otsuji, Kenichi Miyata, Kaoru Yamakawa, Jun Suzuka, Yuri Sakimoto, Yukinori Ozaki, Toshimi Takano, Takeshi Sano, Tetsuo Noda, Shinji Ohno, Ryoji Yao, Takayuki Ueno, Reo Maruyama
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background The intratumor heterogeneity (ITH) of cancer cells plays an important role in breast cancer resistance and recurrence. To develop better therapeutic strategies, it is necessary to understand the molecular mechanisms underlying ITH
Externí odkaz:
https://doaj.org/article/85edbdba6ed3490983b6962991638ed8
Autor:
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Sasako et al. show that disruption of the insulin/IGF-1 signaling by suppressing Akt activity in mouse skeletal muscle can accelerate osteosarcopenia and shortens lifespan, which is reversed by inactivation of FoxOs rather than activation of mTOR, su
Externí odkaz:
https://doaj.org/article/485f04e2a5324e6780b6abc02a8a35ba
Autor:
Kohei Kumegawa, Yoko Takahashi, Sumito Saeki, Liying Yang, Tomoyoshi Nakadai, Tomo Osako, Seiichi Mori, Tetsuo Noda, Shinji Ohno, Takayuki Ueno, Reo Maruyama
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract In breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic response; however, the epigenetic diversity that exists in primary tumors remains unknown. Using a single-cell sequencing assay for transposase-acces
Externí odkaz:
https://doaj.org/article/f27c2438b17d40f492a2f03c6ce25442
Autor:
Norio Tanaka, Seiichi Mori, Kazuma Kiyotani, Yuki Ota, Osamu Gotoh, Shigeru Kusumoto, Nobuaki Nakano, Youko Suehiro, Asahi Ito, Ilseung Choi, Eiichi Ohtsuka, Michihiro Hidaka, Kisato Nosaka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Shinsuke Iida, Atae Utsunomiya, Tetsuo Noda, Hiroyoshi Nishikawa, Ryuzo Ueda, Takashi Ishida
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
In order to identify genomic biomarkers for the outcome of mogamulizumab-containing treatment, an integrated molecular analysis of adult T-cell leukemia/lymphoma (ATL) was conducted on 64 mogamulizumab-naïve patients. Among driver genes, CCR4 and CC
Externí odkaz:
https://doaj.org/article/87b586d60b8342499a82f5af97ec17be
Autor:
Hiroki Osumi, Atsushi Muroi, Mizuho Sakahara, Hiroshi Kawachi, Takuya Okamoto, Yasuko Natsume, Hitomi Yamanaka, Hiroshi Takano, Daisuke Kusama, Eiji Shinozaki, Akira Ooki, Kensei Yamaguchi, Masashi Ueno, Kengo Takeuchi, Tetsuo Noda, Satoshi Nagayama, Naohiko Koshikawa, Ryoji Yao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patie
Externí odkaz:
https://doaj.org/article/4a5d7832b5aa4ee2ae61173e8d40b629
Autor:
Takenori Kotani, Jajar Setiawan, Tasuku Konno, Noriko Ihara, Saki Okamoto, Yasuyuki Saito, Yoji Murata, Tetsuo Noda, Takashi Matozaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates si
Externí odkaz:
https://doaj.org/article/e259b404b0d9467a82163ad3fbd8cc8b
Autor:
Junjiro Yoshida, Tomokazu Ohishi, Hikaru Abe, Shun-ichi Ohba, Hiroyuki Inoue, Ihomi Usami, Masahide Amemiya, Raphael Oriez, Chiharu Sakashita, Shingo Dan, Minoru Sugawara, Tokuichi Kawaguchi, Junko Ueno, Yuko Asano, Ami Ikeda, Manabu Takamatsu, Gulanbar Amori, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Tetsuo Noda, Takumi Watanabe, Takao Shimizu, Masakatsu Shibasaki, Manabu Kawada
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103497- (2021)
Summary: The disruption of the tumor microenvironment (TME) is a promising anti-cancer strategy, but its effective targeting for solid tumors remains unknown. Here, we investigated the anti-cancer activity of the mitochondrial complex I inhibitor int
Externí odkaz:
https://doaj.org/article/ff4620e0f1ac469da0b070bcc9c3a3bb
Autor:
Osamu Gotoh, Yuko Sugiyama, Yutaka Takazawa, Kazuyoshi Kato, Norio Tanaka, Kohei Omatsu, Nobuhiro Takeshima, Hidetaka Nomura, Kosei Hasegawa, Keiichi Fujiwara, Mana Taki, Noriomi Matsumura, Tetsuo Noda, Seiichi Mori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Carcinosarcoma of the ovary or uterus comprises both carcinoma and sarcoma elements. Here, the authors perform a multi -omics study of the disease revealing therapeutic possibilities for this rare and aggressive disease.
Externí odkaz:
https://doaj.org/article/9068e250f9db495ebbfad2a957b29917
Autor:
Wakiko Iwata, Hiroyuki Unoki-Kubota, Hideki Kato, Akira Shimizu, Michihiro Matsumoto, Toshiyuki Imasawa, Arisa Igarashi, Kenji Matsumoto, Tetsuo Noda, Yasuo Terauchi, Masaomi Nangaku, Masato Kasuga, Yasushi Kaburagi
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229397 (2020)
Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model
Externí odkaz:
https://doaj.org/article/2781a5cf89ec49e594b7cf2923e6bc38