Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tetsuo Kiso"'
Publikováno v:
Journal of Pain Research.
Nobuaki Takeshita, Tomoya Oe, Tetsuo Kiso, Shuichiro Kakimoto Drug Discovery Research, Astellas Pharma Inc, Ibaraki, JapanCorrespondence: Nobuaki TakeshitaDrug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7abd48843c23bea3281e4bd0af5d1b9
https://www.dovepress.com/a-kca31-channel-opener-asp0819-modulates-nociceptive-signal-processing-peer-reviewed-article-JPR
https://www.dovepress.com/a-kca31-channel-opener-asp0819-modulates-nociceptive-signal-processing-peer-reviewed-article-JPR
Publikováno v:
Journal of Pain Research
Purpose Although abnormal peripheral and central pain processing has been observed in fibromyalgia (FM) patients, the biomechanics and pathophysiology, surrounding the peripheral mechanism are not well understood. An intermediate conductance channel,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::081ed747ce5287e6b3a6e5e88888230c
https://pubmed.ncbi.nlm.nih.gov/33469353
https://pubmed.ncbi.nlm.nih.gov/33469353
Publikováno v:
British Journal of Pharmacology. 175:3784-3796
Background and purpose Glucocorticoids are a major class of stress hormones known to participate in stress-induced hyperalgesia. Although 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) is a key enzyme in the intracellular regeneration of glucocortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92a66fda7de791c43452dcc8ed56e4f3
https://doi.org/10.1111/bph.14448
https://doi.org/10.1111/bph.14448
Autor:
Toshihiro Watanabe, Koichi Yonezawa, Takahiro Kuramochi, Kazuhiro Ikegai, Seiji Tamura, Norio Asai, Tetsuo Kiso, Akio Kamikawa, Satoshi Miyamoto, Takemoto Yukihiro, Hiromasa Oka, Shohei Shirakami
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3716-3726
A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride (8). SAR studies identified (R)-N-(1-methyl-2-oxo-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e645480def4cc351f241cf20a0e41756
https://doi.org/10.1016/j.bmc.2018.06.001
https://doi.org/10.1016/j.bmc.2018.06.001
Autor:
Hiromasa Oka, Hideki Hiyama, Toshihiro Sekizawa, Tetsuo Kiso, Toshiaki Aoki, Nobuhito Murai, Tomonari Watabiki
Publikováno v:
Neuropharmacology. 126:97-107
Lysophosphatidic acid (LPA) is a bioactive lipid that acts via at least six G protein-coupled receptors, LPA receptors 1-6 (LPA1-6), for various physiological functions. We examined (1) whether LPA5 is involved in pain signaling in the spinal cord; a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac05ccad456207c87686357248cafc7
https://doi.org/10.1016/j.neuropharm.2017.08.032
https://doi.org/10.1016/j.neuropharm.2017.08.032
Publikováno v:
European Journal of Pharmacology. 881:173194
Exogenous cannabinoid receptor agonists are clinically effective for treating chronic pain but frequently cause side effects in the central nervous system. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide, an endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f26679b03eb3f4c74aaba2e836d0f9
https://doi.org/10.1016/j.ejphar.2020.173194
https://doi.org/10.1016/j.ejphar.2020.173194
Autor:
Takashi Ogiyama, Koichi Yonezawa, Seiji Yoshimura, Shuichiro Kakimoto, Makoto Inoue, Jun-Ichi Shishikura, Takayasu Gotoh, Toshihiro Watanabe, Akiko Koakutsu, Tetsuo Kiso, Naoko Katayama
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4638-4648
In lead optimization efforts starting from the tetrahydroisoquinoline (S)-1, we identified 2-{[(2R)-2-hydroxypropyl]amino}-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone ((1S)-8t) as a novel orally active small-molecule N-type ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfdde053acc2da97352d3733c1a4112
https://doi.org/10.1016/j.bmc.2015.05.053
https://doi.org/10.1016/j.bmc.2015.05.053
Autor:
Akiko Koakutsu, Tetsuo Kiso, Takayasu Gotoh, Jun-Ichi Shishikura, Shugo Honda, Takashi Ogiyama, Toshihiro Watanabe, Hiroyoshi Yamada, Makoto Inoue, Shuichiro Kakimoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6899-6907
N-type calcium channels represent a promising target for the treatment of neuropathic pain. The selective N-type calcium channel blocker ziconotide ameliorates severe chronic pain but has a narrow therapeutic window and requires intrathecal administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3944e83805a7c5a2e44c927fe88992
https://doi.org/10.1016/j.bmc.2014.10.020
https://doi.org/10.1016/j.bmc.2014.10.020
Publikováno v:
European journal of pharmacology. 827
Dysfunction of the monoamine systems in the nervous system is associated with the clinical symptoms of fibromyalgia. Reserpine-induced myalgia (RIM) rats are a putative model of fibromyalgia in which muscle pressure thresholds and monoamine content i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352121926b1d9dcdbd42165759df159c
https://pubmed.ncbi.nlm.nih.gov/29530591
https://pubmed.ncbi.nlm.nih.gov/29530591
Autor:
Tomonari Watabiki, Tohru Ozawa, Shuichiro Kakimoto, Tetsuo Kiso, Noriko Tsuji, Fumie Narazaki
Publikováno v:
European journal of pharmacology. 815
Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec6fe692e1483eda3ffc96a6c071617
https://pubmed.ncbi.nlm.nih.gov/29017758
https://pubmed.ncbi.nlm.nih.gov/29017758