Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tetsuo Cai"'
Autor:
Tetsuo Cai, Taisuke Tomita
Publikováno v:
Bio-Protocol, Vol 8, Iss 17 (2018)
Substituted Cysteine Accessibility Method (SCAM) is a biochemical approach to investigate the water accessibility or the spatial distance of particular cysteine residues substituted in the target protein. Protein topology and structure can be annotat
Externí odkaz:
https://doaj.org/article/d23c47a06d16408da063f154fcd72091
Autor:
Tetsuo Cai, Taisuke Tomita
Publikováno v:
Seminars in Cell & Developmental Biology. 105:102-109
Genetic research on familial cases of Alzheimer disease have identified presenilin (PS) as an important membrane protein in the pathomechanism of this disease. PS is the catalytic subunit of γ-secretase, which is responsible for the generation of am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a605cbd515ef89057d094dc3ffe113dd
https://doi.org/10.1016/j.semcdb.2020.02.006
https://doi.org/10.1016/j.semcdb.2020.02.006
Publikováno v:
The Journal of Biochemistry. 167:463-471
Alzheimer disease (AD) is the most common neurodegenerative disease worldwide. The pathological hallmark of AD is the presence of senile plaques in the brain, which are accumulations of amyloid-β peptide (Aβ) ending at the 42nd residue (i.e. Aβ42)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305969552e81cc0c599c5c430c0ce5f9
https://doi.org/10.1093/jb/mvz110
https://doi.org/10.1093/jb/mvz110
Publikováno v:
eNeuro
Visual Abstract
Mutations in the presenilin genes (PS1, PS2) have been linked to the majority of familial Alzheimer’s disease (AD). Although great efforts have been made to investigate pathogenic PS mutations, which ultimately cause an increas
Mutations in the presenilin genes (PS1, PS2) have been linked to the majority of familial Alzheimer’s disease (AD). Although great efforts have been made to investigate pathogenic PS mutations, which ultimately cause an increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3212a9f191dd996471b26d06e7457dca
http://europepmc.org/articles/PMC7932187
http://europepmc.org/articles/PMC7932187
Autor:
Tetsuo Cai, Taisuke Tomita
Publikováno v:
Journal of biochemistry. 170(2)
Alzheimer disease (AD) is the most common neurodegenerative disease worldwide. AD is pathologically characterized by the deposition of senile plaques in the brain, which are composed of an amyloid-β peptide (Aβ) that is produced through the multist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4b4fe399765c1457b115712553eaa7
https://pubmed.ncbi.nlm.nih.gov/33739423
https://pubmed.ncbi.nlm.nih.gov/33739423
Publikováno v:
The Journal of Neuroscience. 37:12272-12280
γ-Secretase is an intramembrane cleaving protease that is responsible for the generation of amyloid-β peptides, which are linked to the pathogenesis of Alzheimer disease. Recently, γ-secretase modulators (GSMs) have been shown to specifically decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a31969118656d47b923b10b8b70dc0
https://doi.org/10.1523/jneurosci.1628-17.2017
https://doi.org/10.1523/jneurosci.1628-17.2017
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(43)
γ-Secretase is an intramembrane-cleaving protease that generates the toxic species of the amyloid-β peptide (Aβ) that is responsible for the pathology of Alzheimer disease. The catalytic subunit of γ-secretase is presenilin 1 (PS1), which is a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84454b2875f46a0cc309841587262912
https://pubmed.ncbi.nlm.nih.gov/31527118
https://pubmed.ncbi.nlm.nih.gov/31527118
Publikováno v:
The Journal of Neuroscience. 36:1362-1372
γ-Secretase is an intramembrane-cleaving protease that produces amyloid-β peptide 42 (Aβ42), which is the toxic and aggregation-prone species of Aβ that causes Alzheimer's disease. Here, we used the substituted cysteine accessibility method to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cfee3e410bb1f89ef52a6440da1404
https://doi.org/10.1523/jneurosci.5090-14.2016
https://doi.org/10.1523/jneurosci.5090-14.2016
Publikováno v:
Journal of Biological Chemistry. 291:435-446
γ-Secretase is a multisubunit membrane protein complex containing presenilin (PS1) as a catalytic subunit. Familial Alzheimer disease (FAD) mutations within PS1 were analyzed in yeast cells artificially expressing membrane-bound substrate, amyloid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df057b073a6eff97745f82e963134c2a
https://doi.org/10.1074/jbc.m114.629287
https://doi.org/10.1074/jbc.m114.629287
Autor:
Tetsuo Cai, Satoko Osawa, Takeshi Iwatsubo, Taisuke Tomita, Shizuka Takagi-Niidome, Takeshi Sato, Kanan Morishima, Tomoki Sasaki
Publikováno v:
The Journal of Neuroscience. 35:2646-2656
γ-Secretase is a multisubunit protease complex that is responsible for generating amyloid-β peptides, which are associated with Alzheimer disease. The catalytic subunit of γ-secretase is presenilin 1 (PS1), which contains an initial substrate-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe9566f774a44170d9d0a69d34a39bd
https://doi.org/10.1523/jneurosci.3164-14.2015
https://doi.org/10.1523/jneurosci.3164-14.2015