Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tetsumi Hosokawa"'
Publikováno v:
International Journal of Biological Sciences, Vol 5, Iss 4, Pp 304-310 (2009)
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low
Externí odkaz:
https://doaj.org/article/723f05925933449e92aa6061352e311f
Autor:
Hitonobu Tomoike, Kyoko Terashita, Tetsumi Hosokawa, Shuichi Kato, Noriaki Takabatake, Shuichi Abe, Hiroshi Saito, Minoru Inage, Makoto Sata, Manabu Ogura, Toshihiko Hino, Hidenori Nakamura
Publikováno v:
International Journal of Biological Sciences
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c476851774f9ddf59e65ed1074760e9
https://doi.org/10.7150/ijbs.5.304
https://doi.org/10.7150/ijbs.5.304
Autor:
Keiko Koga, Goro Miyakoda, Toyoki Mori, Makoto Ishikawa, Yongkyu Lee, Jeong Hyun Lee, Tetsumi Hosokawa, Mari Fukunaga, Ki Whan Hong
Publikováno v:
Brain Research. 994:91-98
To investigate the effects of cilostazol on the hemispheric ischemic lesion, we monitored the apparent diffusion coefficient (ADC) and T2 images by MRI techniques in comparison with histology at the terminal of and after 24-h reperfusion following 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b1503007dc0e29d7e35dca2b774550
https://doi.org/10.1016/j.brainres.2003.09.021
https://doi.org/10.1016/j.brainres.2003.09.021
Autor:
Takafumi Fujioka, Takumi Sumida, Tetsumi Hosokawa, Shuji Teramoto, Youichi Yabuuchi, Michiaki Tominaga, Toyoki Mori
Publikováno v:
ChemInform. 24
A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a potent activity with none or negative chronotropic effect in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50fea26d37ff65cb3088e514e15273cb
https://doi.org/10.1002/chin.199320218
https://doi.org/10.1002/chin.199320218
Autor:
Kazumi Takemoto, Youichi Yabuuchi, Michiaki Tominaga, Toyoki Mori, Takafumi Fujioka, Sachiko Tsujimi, Tetsumi Hosokawa, Shuji Teramoto, Takumi Sumida
Publikováno v:
ChemInform. 28
The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinon e (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7379e7b3529c801df5f8765f9b59276
https://doi.org/10.1002/chin.199711118
https://doi.org/10.1002/chin.199711118
Autor:
Youichi Yabuuchi, Michiaki Tominaga, Shuji Teramoto, Takumi Sumida, Tetsumi Hosokawa, Toyoki Mori, Takafumi Fujioka
Publikováno v:
Journal of Medicinal Chemistry. 35:3607-3612
A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a potent activity with none or negative chronotropic effect in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd75ee30e945a740f09def68eb969260
https://doi.org/10.1021/jm00098a003
https://doi.org/10.1021/jm00098a003
Autor:
Teruo Noda, Tetsumi Hosokawa, Michiaki Tominaga, Takashi Imaizumi, Hiroyuki Fujiki, Shizuo Kinoshita, Makoto Ohura, Youichi Yabuuchi, Toyoki Mori, Kazumi Takemoto
Publikováno v:
Heart and Vessels. 7:66-75
OPC-18790 [(+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]- 2(1H)-quinolinone], a novel positive inotropic agent, was investigated in several in vitro and in vivo experiments to elucidate its cardiovascular effects and its mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71308829ed9fbacf5cd5c44343f809f7
https://doi.org/10.1007/bf01744451
https://doi.org/10.1007/bf01744451
Autor:
Toshiyuki Onogawa, Hidenori Ogawa, Hisashi Miyamoto, Tomihiko Chihara, Toyoki Mori, Hiroshi Yamashita, Shigeki Nakamura, Michiaki Tominaga, Youichi Yabuuchi, Tatsuya Yamashita, Yoshitaka Yamamura, Tetsumi Hosokawa
Publikováno v:
British Journal of Pharmacology. 105:787-791
1. OPC-31260, a benzazepine derivative, has been studied for its ability to antagonize the binding of arginine vasopressin (AVP) to receptors in rat liver (V1) and kidney (V2) plasma membranes, for antagonism of the antidiuretic action of AVP in alco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89096202f1d7c66db13136c742f12317
https://doi.org/10.1111/j.1476-5381.1992.tb09058.x
https://doi.org/10.1111/j.1476-5381.1992.tb09058.x
Autor:
Tetsumi Hosokawa, Takafumi Fujioka, Michiaki Tominaga, Shuji Teramoto, Toyoki Mori, Takumi Sumida, Kazumi Takemoto, Sachiko Tsujimi, Youichi Yabuuchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:1596-1598
The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinon e (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d49fc12f4173f9fd9b387005963d0c4
https://doi.org/10.1248/cpb.44.1596
https://doi.org/10.1248/cpb.44.1596
Publikováno v:
Heart and vessels. 6(3)
OPC-8490 [3,4-dihydro-6-[4-(4-oxo-4-phenylbutyl)-1- piperazinylcarbonyl]-2(1H)-quinolinone citrate] elicited a positive inotropic effect in a concentration-dependent manner on the isolated dog ventricular trabeculae electrically driven at 0.5 Hz in K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43720b73d74430d956ac084dbd02a3fc
https://pubmed.ncbi.nlm.nih.gov/1655692
https://pubmed.ncbi.nlm.nih.gov/1655692