Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Tetsuji Ozawa"'
1
Development of an Efficient Scale-Up Synthesis Method for a β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride
Autor: Kyoko Nakagawa-Goto, Hidetoshi Isawa, Tetsuji Ozawa, Masahiro Kobayashi, Takehiro Ishikawa, Masayuki Nishimura, Norihiko Kikuchi, Ritsu Suzuki, Junichi Sonehara, Yohei Saito, Takayuki Ainai, Kiyoshi Kasai, Kobayashi Makoto
Publikováno v: Organic Process Research & Development. 24:1675-1682
An efficient route for the multikilogram synthesis of a selective β3-adrenergic receptor agonist, ritobegron ethyl hydrochloride (1), was developed by changing the coupling method of 4-hydroxynorep...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dafadea840aac24db40213f0c214e40
https://doi.org/10.1021/acs.oprd.0c00278
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2
Synthesis and optimization of novel α-phenylglycinamides as selective TRPM8 antagonists
Autor: Yoshikazu Fujimori, Noboru Kamada, Tomonaga Ozawa, Osamu Nakanishi, Tetsuya Ikeda, Tetsuji Ozawa, Hiroo Takeda, Jun-ichi Kobayashi, Hideaki Hirasawa
Publikováno v: Bioorganic & Medicinal Chemistry. 25:727-742
Transient receptor potential melastatin 8 (TRPM8) is activated by innocuous cold and chemical substances, and antagonists of this channel have been considered to be effective for pain and urinary diseases. N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c065268d9434ea08f7266cd9844503
https://doi.org/10.1016/j.bmc.2016.11.049
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3
O-Glycosylation of 4-(Substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one Derivatives with 2,3,4,6-Tetra-O-acyl-α-D-glucopyranosyl Bromide via N1-Acetylation of the Pyrazole Ring
Autor: Tetsuji Ozawa, Junichi Sonehara, Hidetoshi Isawa, Minoru Kubota, Masahiro Kobayashi
Publikováno v: CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1009-1018
A practical preparation of 4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 2 is described. O-Glycosylation of 4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one derivative 3 was facilitated by introducti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e11bf24fe3cd98e06cc7b0abfe139bc3
https://doi.org/10.1248/cpb.c15-00982
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4
O-Glycosylation of 4-(Substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one Derivatives with 2,3,4,6-Tetra-O-acyl-α-D-glucopyranosyl Bromide via N1-Acetylation of the Pyrazole Ring
Autor: Masahiro, Kobayashi, Hidetoshi, Isawa, Junichi, Sonehara, Minoru, Kubota, Tetsuji, Ozawa
Publikováno v: Chemicalpharmaceutical bulletin. 64(7)
A practical preparation of 4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 2 is described. O-Glycosylation of 4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one derivative 3 was facilitated by introducti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a2a2c1e2803a990b2af123dffa6f18d
https://pubmed.ncbi.nlm.nih.gov/27373664
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5
Effects of Tachykinins and Histamine on the Expression of Thymus- and Activation-Regulated Chemokine mRNA in Peripheral Blood Mononuclear Cells and Human Bronchial Epithelial Cells
Autor: Keita Kasahara, Yasuko Nakano, Yoji Iikura, Keiko Takekawa, Tetsuji Ozawa, Mitsuru Adachi, Kazue Satoh, Takaharu Negoro, Takashi Tobe
Publikováno v: Journal of Health Science. 48:534-544
We hypothesized that participation of sensory neuropeptides, substance P and neurokinin A in the airway inflammation caused to resistance against the glucocorticoids (GCs) treatment. We have measured the expression level of cytokines and chemokines m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf00fe4844e7f4349fd6dec9917351df
https://doi.org/10.1248/jhs.48.534
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7
Patterns of Relapse and Procedures for Detecting Relapse after Complete or Partial Response in Patients with Small Cell Lung Cancer
Autor: Tetsuji Ozawa, Takeshi Yoshida, Kentaro Okuda, Takashi Hirose, Keigo Tominaga, Suguru Machida, Mitsuru Adachi, Munehide Noda, Kiyoshi Mori, Kohei Yokoi
Publikováno v: Haigan. 39:267-273
最近11年間に治療に奏効した肺小細胞癌85例を対象に再発形式, 再発の発見動機についてレトロスペクティブに検討した. 再発・再燃したのは60例, 77部位で, 限局型・進展型症例共に胸郭内
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae70a4134d6f8086851bae243b0b272e
https://doi.org/10.2482/haigan.39.267
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9
Patients preferences in chemotherapy for advanced non-small-cell lung cancer
Autor: Tetsuji Ozawa, Tsukasa Ohnishi, Takao Shirai, Takashi Hirose, Sohjiroh Kusumoto, Mitsuru Adachi, Tohru Ohmori, Naoya Horichi, Tomohide Sugiyama
Publikováno v: Internal medicine (Tokyo, Japan). 44(2)
Objective To determine how Japanese patients with lung cancer weigh potential survival, chemotherapy response rate, and symptom relief against the potential toxicity of different treatments in cancer chemotherapy.Methods and Patients We used a questi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa0131c7c453b8ddae34d1ebe8afa53
https://pubmed.ncbi.nlm.nih.gov/15750269
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10
Total synthesis of the marine alkaloids (-)-lepadins a, b, and c based on stereocontrolled intramolecular acylnitroso-Diels-Alder reaction
Autor: Chihiro Kibayashi, Tetsuji Ozawa, Sakae Aoyagi
Publikováno v: The Journal of organic chemistry. 66(10)
The first syntheses of (-)-lepadins A and C, as well as a new synthesis of (-)-lepadin B, have been achieved from commercially available (S)-malic acid. The methodology is based on an intramolecular hetero-Diels--Alder reaction of the acylnitroso com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393a96e35fa4df6e1ccfe224cecce563
https://pubmed.ncbi.nlm.nih.gov/11348115
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