Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Tetsuji, Kawamoto"'
Autor:
Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, Hiromichi Sugimoto, Kei Masuda, Norio Ohyabu, Yoshihiro Banno, Norihito Tokunaga, Tetsuji Kawamoto, Yoshihide Tomata, Yasumi Kumagai, Motoo Iida, Yoichi Nagano, Mariko Yoneyama-Hirozane, Yuji Shimizu, Katsunori Sasa, Takashi Ishikawa, Hiroshi Yukitake, Mitsuhiro Ito, Kazunobu Aoyama, Takahiro Matsumoto
Publikováno v:
ACS Medicinal Chemistry Letters. 13:457-462
TAK-925, a potent, selective, and brain-penetrant orexin 2 receptor (OX2R) agonist, [methyl (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87b9a348e001ee09f5f334fe8ecffc
https://doi.org/10.1021/acsmedchemlett.1c00626
https://doi.org/10.1021/acsmedchemlett.1c00626
Autor:
Daichi Koiwa, Masayuki Ohira, Takahiro Hiramatsu, Hidenori Abe, Tetsuji Kawamoto, Yuji Ishihara, Bernardo Ignacio, Noel Mansour, Todd Romoff
Publikováno v:
Organicbiomolecular chemistry. 20(42)
A continuous-flow quaternization reaction of gramines with MeI (lt;1 min) followed by a substitution reaction with a chiral nucleophilic glycine-derived Ni-complex (iS/i)-2 (lt;1 min) has successfully been developed to afford the corresponding alkyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fde49b033fd82ae7e7356617ecc5ff1
https://pubmed.ncbi.nlm.nih.gov/36250233
https://pubmed.ncbi.nlm.nih.gov/36250233
Application of Continuous Flow-Flash Chemistry to Scale-up Synthesis of 5-Cyano-2-formylbenzoic Acid
Autor:
Koichiro Fukuda, Shinichi Masada, David G. Cork, Masaki Seto, Hirotsugu Usutani, Tetsuji Kawamoto
Publikováno v:
Organic Process Research & Development. 23:1420-1428
Efficient scale-up synthesis of 5-cyano-2-formylbenzoic acid or its cyclic isomer 6-cyano-3-hydroxy-2-benzofuran-1(3H)-one (1) as a key intermediate for various biologically important compounds has been achieved from isopropyl 2-bromo-5-cyanobenzoate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72454ea0f4681285c6fb791ee7666b16
https://doi.org/10.1021/acs.oprd.9b00180
https://doi.org/10.1021/acs.oprd.9b00180
Publikováno v:
Tetrahedron. 75:617-623
Continuous photo flow synthesis of tert-butyl 3-oxo-2-oxabicyclo[2.2.0]hex-5-ene-6-carboxylate (2b) from tert-butyl 2-oxo-2H-pyran-5-carboxylate (1b) has been investigated for scale-up synthesis of cis-3-(tert-butoxycarbonyl)-2,3,4-d3-cyclobutanecarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a34d042a4039b8c219290cd4e2a4954e
https://doi.org/10.1016/j.tet.2018.12.037
https://doi.org/10.1016/j.tet.2018.12.037
Autor:
Makoto Kanematsu, Koichiro Fukuda, Tetsuji Kawamoto, David G. Cork, Shinichi Masada, Hirotsugu Usutani, Shotaro Miura
Publikováno v:
Organic & Biomolecular Chemistry. 17:8166-8174
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M1 positive allosteric modulator 1 bearing an isoindolin-1-one ring system as a pharmacophore has been achieved using flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb389d09fa134081045ffd9fc9cfb09
https://doi.org/10.1039/c9ob01718f
https://doi.org/10.1039/c9ob01718f
Autor:
Junya Shirai, Yoshiyuki Fukase, Tetsuji Kawamoto, Mitsunori Kono, Tsuneo Oda, Mikio Shirasaki, Yasushi Fujitani, Hiroyuki Watanabe, Hideyuki Nakagawa, Keiko Uga, Michiko Tawada, Naohiro Taya, Akira Shibata, Takashi Imada, Yoshihide Tomata, Masashi Yamasaki, Tomoya Yukawa, Shoji Fukumoto, Hidekazu Tokuhara, Satoshi Yamamoto, Naoki Ishii, Atsuko Ochida, Yoshihiro Banno
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:470-482
A series of tetrahydroisoquinoline derivatives were designed, synthesized, and evaluated for their potential as novel orally efficacious retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of Th17-driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525a6e1c5124e88399900d795fac2e06
https://doi.org/10.1016/j.bmc.2017.12.008
https://doi.org/10.1016/j.bmc.2017.12.008
Autor:
Mitsuhisa Yamano, Ryo Mizojiri, Tatsuya Ito, Kazuaki Takami, Maeda Hiroyuki, Tetsuji Kawamoto
Publikováno v:
Organic Process Research & Development. 21:1034-1041
Efficient and stereoselective syntheses of isomerically pure 4-aminotetrahydro-2H-thiopyran 1-oxide derivatives have successfully been achieved. Isomerically pure (4-nitrophenyl)sulfonyltetrahydro-2H-thiopyran 1-oxides were identified by X-ray crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98f0ff1897f55c623f97d48ff0d0f21
https://doi.org/10.1021/acs.oprd.7b00147
https://doi.org/10.1021/acs.oprd.7b00147
Autor:
Shotaro, Miura, Koichiro, Fukuda, Shinichi, Masada, Hirotsugu, Usutani, Makoto, Kanematsu, David G, Cork, Tetsuji, Kawamoto
Publikováno v:
Organicbiomolecular chemistry. 17(35)
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84ae116701def7529a8e6a4961e98e79
https://pubmed.ncbi.nlm.nih.gov/31464336
https://pubmed.ncbi.nlm.nih.gov/31464336
Autor:
Naohiro Taya, Chien-Hung Chen, Tsuneo Oda, Bi-Ching Sang, Tomoya Yukawa, Takayuki Sato, Yoshi Nara, Noriko Uchiyama, Zenyu Shiokawa, Terufumi Takagi, Satoshi Yamamoto, Ayumu Sato, Ryokichi Koyama, Nobuyuki Negoro, Gyorgy Snell, Junya Shirai, Ryosuke Katsuyama, Takashi Imada, Yoshihiro Banno, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 62(3)
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe a novel structure-based functionality sw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1871e7ef2034f04a5ead2918edf01322
https://pubmed.ncbi.nlm.nih.gov/30652849
https://pubmed.ncbi.nlm.nih.gov/30652849
Autor:
Keiko Igaki, Yoshihiro Banno, Tsuneo Oda, Akira Shibata, Bi-Ching Sang, Masashi Yamasaki, Hideyuki Nakagawa, Atsuko Ochida, Hidekazu Tokuhara, Kazuko Yonemori, Junya Shirai, Satoshi Yamamoto, Yoshiyuki Fukase, Gyorgy Snell, Shinichi Masada, Tomoya Yukawa, Yoshi Nara, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Noboru Tsuchimori, Yoshiki Nakamura, Keiko Uga, Takashi Imada, Naohiro Taya, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 61(7)
A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9548ec5d97f7b04e014802ee8f90a5b0
https://pubmed.ncbi.nlm.nih.gov/29510038
https://pubmed.ncbi.nlm.nih.gov/29510038