Výsledky vyhledávání - "Tetsuhiro Kawabe"

Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1

Autor: Tomohiro Yoshida, Tetsuhiro Kawabe, Lewis C. Cantley, Costas A. Lyssiotis

Publikováno v: Biochemistry. 61:1548-1553

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d327397cd7f355a6e22fd7c4166b33a0
https://doi.org/10.1021/acs.biochem.2c00123

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Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP

Autor: Tomohiro, Yoshida, Tetsuhiro, Kawabe, Lewis C, Cantley, Costas A, Lyssiotis

Publikováno v: Biochemistry. 61(15)

NADP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5975cbcf93a14001ba00698e9e6100a
https://pubmed.ncbi.nlm.nih.gov/35819845

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Modelling and Prevention of Acute Kidney Injury through Ischemia and Reperfusion in a Combined Human Renal Proximal Tubule/Blood Vessel-on-a-Chip

Autor: Kazuhiro Tetsuka, Laura M Tool, Fumiko Kiyonaga, Marianne K. Vormann, Akira Fujimori, Masato Ohbuchi, Paul Vulto, Thomas Hankemeier, Takayuki Goto, Remko van Vught, Linda Gijzen, Henriëtte L. Lanz, Tetsuhiro Kawabe

Publikováno v: Kidney360

Background: Renal ischemia/reperfusion injury (rIRI) is one of the major causes of acute kidney injury (AKI). While animal models are suitable for investigating systemic symptoms of AKI they are limited in translatability. Human in vitro models are c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13dda44bc10390b4a5e7a95719ab5001
https://europepmc.org/articles/PMC8967632/

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Reconstituted Human Organ Models as a Translational Tool for Human Organ Response: Definition, Expectations, Cases, and Strategies for Implementation in Drug Discovery and Development

Autor: Masato Ohbuchi, Kaori Takama, Shunji Yamazaki, Akira Fujimori, Kazuhiro Tetsuka, Takayuki Goto, Fumiko Kiyonaga, Tetsuhiro Kawabe

Publikováno v: Biologicalpharmaceutical bulletin. 43(3)

Recent progress in the fields of tissue engineering, micro-electro mechanical systems, and materials science have greatly improved cell culture systems, which were traditionally performed in a static two-dimensional manner. This progress has led to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90cfc80486bb687169794516b75c8e6
https://pubmed.ncbi.nlm.nih.gov/32115499

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Roles of Conserved Arginine Residues in the Metal−Tetracycline/H+ Antiporter of Escherichia coli

Autor: Tomomi Kimura, Tetsuhiro Kawabe, Akihito Yamaguchi, Mariko Nakatani

Publikováno v: Biochemistry. 37:5475-5480

Seven arginine residues are conserved in all the tetracycline/H+ antiporters of Gram-negative bacteria. Four (Arg67, -70, -71, and -127) of them are located in the putative cytoplasmic loop regions and three (Arg31, -101, and -238) in the putative pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f81aafed69476e07d8d22ffc754a82
https://doi.org/10.1021/bi973188g

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Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2

Autor: Akihito Yamaguchi, Shigeyuki Nada, Tetsuhiro Kawabe, Sunghi Ryu

Publikováno v: The Journal of biological chemistry. 275(50)

Multidrurg resistance-associated protein 2 (MRP2)/canalicular multispecific organic anion transporter (cMOAT) is involved in the ATP-dependent export of organic anions across the bile canalicular membrane. To identify functional amino acid residues t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9357f757cbd1572286a22f0d7353d23
https://pubmed.ncbi.nlm.nih.gov/10978330

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Molecular construction of a multidrug exporter system, AcrAB: molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal sequence of AcrA

Autor: Akihito Yamaguchi, Tetsuhiro Kawabe, Erika Fujihira

Publikováno v: Journal of biochemistry. 128(2)

The AcrAB system of Escherichia coli is an intrinsic efflux protein with a broad substrate specificity. AcrA was thought to be localized in the periplasmic space, and to be linked to AcrB and TolC. The AcrAB-TolC system directly exports diverse subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41145603799332625214770aa766e06f
https://pubmed.ncbi.nlm.nih.gov/10920254

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Proximity of periplasmic loops in the metal-Tetracycline/H(+) antiporter of Escherichia coli observed on site-directed chemical cross-linking

Autor: Yoshiyuki Kubo, Shigeyuki Nada, Tetsuhiro Kawabe, Satoko Konishi, Akihito Yamaguchi

Publikováno v: The Journal of biological chemistry. 275(8)

Our previous study on second-site suppressor mutations of the Tn10-encoded metal-tetracycline/H(+) antiporter suggested that Leu(30) and Ala(354), located in periplasmic loop 1-2 and 11-12, respectively, are conformationally linked to each other (Kaw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b4c01bea35e8bac3e17ecf5d20af0c
https://pubmed.ncbi.nlm.nih.gov/10681498

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Transmembrane remote conformational suppression of the Gly-332 mutation of the Tn10-encoded metal-tetracycline/H+ antiporter

Autor: Akihito Yamaguchi, Tetsuhiro Kawabe

Publikováno v: FEBS Letters. (1):169-173

Gly-332 is a conformationally important residue of the Tn 10 -encoded metal-tetracycline/H + antiporter (TetA(B)), which was found by random mutagenesis and confirmed by site-directed mutagenesis. A bulky side chain at position 332 is deleterious to

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