Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Tetsuhiro Horie"'
Autor:
Takuya Sakamoto, Atsushi Fuku, Tetsuhiro Horie, Hironori Kitajima, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Yasuo Iida, Sohsuke Yamada, Naoki Yamamoto, Yusuke Shimizu, Yasuhito Ishigaki, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara
Publikováno v:
Regenerative Therapy, Vol 27, Iss , Pp 408-418 (2024)
Introduction: Administration of adipose-derived stem cells (ADSCs) into the joint cavity has been shown to alleviate the symptoms of knee osteoarthritis (OA) by releasing exosomes and anti-inflammatory cytokines. However, the therapeutic effect of th
Externí odkaz:
https://doaj.org/article/5db03e3e0b08483f918dd97cfe2fb99c
Autor:
Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect pri
Externí odkaz:
https://doaj.org/article/69274c6ccd734fd68d05813f708b0c90
Autor:
Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Hiraiwa et al. show that phosphorylation of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) at Thr249 mediates ubiquitylation and degradation of the TGF-β receptor TGBR1 leading to loss of glioblastoma stem cell tumorigenic capacity. Their data
Externí odkaz:
https://doaj.org/article/947620c5dbce49479302679a911d0d45
Autor:
Shinsuke Ochiai, Kazuya Tokumura, Gyujin Park, Kakeru Ozaki, Tetsuhiro Horie, Takanori Yamada, Sayuki Iwahashi, Kaname Ohta, Hiroki Fusawa, Yasuka Okayama, Katsuyuki Kaneda, Takashi Iezaki, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://doaj.org/article/8bb19e32b3b8492a93d071b9d27caabe
Autor:
Hironori Kitajima, Takuya Sakamoto, Tetsuhiro Horie, Ayane Kuwano, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Naoki Yamamoto, Yasuo Iida, Yasuhito Ishigaki, Sohsuke Yamada, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara
Publikováno v:
Cells, Vol 12, Iss 2, p 330 (2023)
Knee osteoarthritis (Knee OA) is an irreversible condition that causes bone deformity and degeneration of the articular cartilage that comprises the joints, resulting in chronic pain and movement disorders. The administration of cultured adipose-deri
Externí odkaz:
https://doaj.org/article/d2049a19df7241e0845c96e4b928d18d
Autor:
Takashi Iezaki, Tetsuhiro Horie, Kazuya Fukasawa, Makoto Kitabatake, Yuka Nakamura, Gyujin Park, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Takayuki Manabe, Yasuhito Ishigaki, Mutsuhito Ohno, Eiichi Hinoi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs
Externí odkaz:
https://doaj.org/article/a74140fb7e634b20b5faa27345d65c2c
Autor:
Manami Hiraiwa, Kakeru Ozaki, Takanori Yamada, Takashi Iezaki, Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Hikari Kamada, Kazuya Tokumura, Mei Motono, Katsuyuki Kaneda, Eiichi Hinoi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease. Bone homeostasis is maintained by the actions of bone-resorbing osteoclasts and
Externí odkaz:
https://doaj.org/article/77d5728b82864ecfb103a2d6f83a5a78
Autor:
Jiajun Lyu, Takuya Kubo, Sayuki Iwahashi, Kazuya Fukasawa, Tetsuhiro Horie, Katashi Nagamatsu, Kumiko Ikeno, Genjiro Nakamura, Masaki Kamakura, Eiichi Hinoi
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:348-353
Autor:
Sayuki Iwahashi, Jiajun Lyu, Kazuya Tokumura, Ryoma Osumi, Manami Hiraiwa, Takuya Kubo, Tetsuhiro Horie, Satoru Demura, Noriaki Kawakami, Taku Saito, Gyujin Park, Kazuya Fukasawa, Takashi Iezaki, Akane Suzuki, Akane Tomizawa, Hiroki Ochi, Hironori Hojo, Shinsuke Ohba, Eiichi Hinoi
Publikováno v:
Journal of Cellular Physiology. 237:4292-4302
Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L-type amino acid transporter 1 (LAT1), encoded by solute carrier transporter 7a5 (Slc7a5), plays a crucial role in amino acid sensing and
Autor:
Eiichi Hinoi, Atsushi Hirao, Tomoki Todo, Masaki Kobayashi, Misato Murata, Kazuya Tokumura, Sayuki Iwahashi, Ryoma Osumi, Akane Tomizawa, Tetsuhiro Horie, Akane Suzuki, Yuki Tanaka, Takuya Kubo, Jiajun Lyu, Kazuya Fukasawa
Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788882a8a69ae7af65c2328f7f80e380
https://doi.org/10.1158/2767-9764.22546025
https://doi.org/10.1158/2767-9764.22546025