Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tetsuhiko Toyoshima"'
Autor:
Richard F. Keep, Tetsuhiko Toyoshima, Yanan Liu, Takashi Tamiya, Aya Shinomiya, Toshifumi Itano, Masaaki Tokuda, Takehiro Nakamura
Publikováno v:
Brain Research Bulletin. 109:127-131
The present study investigates the neuroprotective effects of d-allose, a rare sugar, against ischemia/reperfusion injury in a gerbil model. Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 min. D-A
Autor:
Kazunori Sumitani, Toshifumi Itano, Feng Lu, Takehiro Nakamura, Tetsuhiko Toyoshima, Tohru Yamamoto, Richad F. Keep, Aya Shinomiya, Takashi Tamiya, Yanan Liu
Publikováno v:
Brain Research. 1543:300-307
The aim of this study was to investigate the neuroprotective effects of yokukansan, a traditional Kampo medicine, on the behavioral dysfunction induced by cerebral ischemia/reperfusion injury in gerbils. Gerbils were treated with yokukasan by oral ga
Autor:
Junzaburo Minami, Osamu Matsushita, Akinobu Okabe, Tetsuhiko Toyoshima, Nozomu Nishi, Toshifumi Itano
Publikováno v:
Connective Tissue Research. 42:281-290
The substrate spectrum of the tandem collagen-binding domain (CBD) of Clostridium histolyticum class I collagenase (Co1G) was examined both in vitro and in vivo. CBD bound to insoluble type I, II, III and IV collagens in vitro, and to skin, aorta, te
Autor:
Tsuyoshi Shishibori, Yuirou Hata, Hiroshi Tokumitsu, Tetsuhiko Toyoshima, Ryoji Kobayashi, Shigehiko Suzuki, Miki Okada, Toshifumi Itano, Kayoko Yamashita, Hiromi Furuichi
Publikováno v:
Biochemical and Biophysical Research Communications. 270:1002-1008
To elucidate the molecular mechanism involved in the suppression of keloids and hypertrophic scars by tranilast, we investigated the target protein of tranilast in bovine skin and aorta. A specific tranilast-binding protein was isolated from both tis
Autor:
Shin-ichi Yamagami, Tetsuhiko Toyoshima, Toshifumi Itano, Osamu Miyamoto, S. Nagao, Takehiro Nakamura, Tetsuro Negi
Publikováno v:
Acta Neurochirurgica. 141:407-413
The long-term effects of post-ischaemic hypothermia are controversial. The purpose of this study was to examine the long-term effects of post-ischaemic hypothermia on neuronal survival in gerbils in terms of morphology and function. Hypothermia was i
Autor:
Najma A. Janjua, Taeko Minami, Naomi Honjo-fujiwara, Hiroko Kondo, Toshifumi Itano, Motoomi Ohkawa, Osamu Miyamoto, Tetsuhiko Toyoshima, Saeko Oka, Seigo Nagao
Publikováno v:
NeuroReport. 10:937-940
To study the sexual dimorphism of human corpus cauosum (CC), we analyzed the midsaggital magnetic resonance imaging (MRI) morphometry in 67 adults aged (mean+/-s.d.) 36.82+/-9.35 years. Four specific angles of the CC were determined. All four angles
Autor:
Ryoji Kobayashi, Li Jin, Toshifumi Itano, Tetsuhiko Toyoshima, Tetuhide H. Murakami, Osamu Miyamoto
Publikováno v:
Archives of Dermatological Research. 289:578-584
The subcellular localization of the protein calbindin-D28k in normal and incised mouse skin was investigated by immunohistochemical staining and immunoblot analysis. In normal skin, the presence of calbindin-D28k was demonstrated in both the nucleus
Autor:
Richard F. Keep, Takehiro Nakamura, Yanan Liu, Toshifumi Itano, Feng Lu, Aya Shinomiya, Osamu Miyamoto, Takashi Tamiya, Naohiko Okabe, Tetsuhiko Toyoshima, Kazuyuki Hirooka
Publikováno v:
Brain research. 1548
The present study investigates the potential protective effects of granulocyte colony-stimulating factor (G-CSF) and underlying mechanisms in a gerbil model of global cerebral ischemia. We examined neuronal death, inflammatory reaction and neurogenes
Autor:
Sylvie Mellouk, P. De La Vega, V. Fallarme, Stephen L. Hoffman, Yupin Charoenvit, Masamichi Aikawa, Richard L. Beaudoin, M. F. Leef, Martha Sedegah, Tetsuhiko Toyoshima
Publikováno v:
Experimental Parasitology. 80:419-429
Infected hepatocytes are important targets for malaria vaccines. To identify Plasmodium yoelii proteins expressed in infected hepatocytes, we immunized BALB/c ByJ mice with P. yoelii liver stage schizonts and produced a panel of monoclonal antibodies
Autor:
Kazuyuki Hirooka, Naohiko Okabe, Nobuyuki Kawai, Toshifumi Itano, Feng Lu, Yanan Liu, Richard F. Keep, Takashi Tamiya, Fumio Shiraga, Tetsuhiko Toyoshima, Takehiro Nakamura, Osamu Miyamoto
Publikováno v:
Neuroscience letters. 506(1)
The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3 mg/kg; i.p.) 30 min before transient forebrain ischemia, which was induced by occluding the bilatera