Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Tetsuaki Tanaka"'
Autor:
Naoto Kojima, Tetsuaki Tanaka
Publikováno v:
Molecules, Vol 14, Iss 9, Pp 3621-3661 (2009)
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-
Externí odkaz:
https://doaj.org/article/695a3c2591654aa582c2172a13d409f5
Autor:
Tetsuaki Tanaka, Shingo Dan, Masayuki Yamashita, Takuya Matsumoto, Akinobu Akatsuka, Takao Yamori, Yuki Suga, Hiroki Iwasaki, Naoto Kojima
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:1276-1283
The convergent synthesis of the dansyl-labeled probe of the thiophene-3-carboxamide analogue of annonaceous acetogenins, which shows potent antitumor activity, was accomplished by two asymmetric alkynylations of the 2,5-diformyl THF equivalent with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6977e34b7beac0652d1a35faeb46a09
https://doi.org/10.1016/j.bmc.2015.01.037
https://doi.org/10.1016/j.bmc.2015.01.037
Autor:
Naoto Kojima, Mutsumi Okamura, Takahiro Tatsukawa, Hiroki Iwasaki, Shingo Dan, Akinobu Akatsuka, Takao Yamori, Masayuki Yamashita, Tetsuya Fushimi, Tetsuaki Tanaka
Publikováno v:
European Journal of Medicinal Chemistry. 86:684-689
Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized, and their inhibitory activities toward human cancer cell lines were evaluated. The analogues showed more potent activities than natural acetogenin. One of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1544d7fe1c9325515f790d04ef089eba
https://doi.org/10.1016/j.ejmech.2014.09.026
https://doi.org/10.1016/j.ejmech.2014.09.026
Autor:
Mutsumi Iuchi, Tetsuaki Tanaka, Hiroaki Ohno, Nobutaka Fujii, Naoto Kojima, Takehiko Yoshimitsu
Publikováno v:
Chemistry - A European Journal. 18:5352-5360
Palladium-catalyzed cascade C-H alkenylation and arylation provides convenient access to polycyclic aromatic compounds. Treatment of 3-bromoaniline derivatives bearing a bromocinnamyl group on the nitrogen atom with a catalytic amount of [Pd(OAc)(2)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7fd139f7d47c9add248d978e19a0fd
https://doi.org/10.1002/chem.201103819
https://doi.org/10.1002/chem.201103819
Publikováno v:
Synthesis. 2011(16):2567-2578
Cascade cyclization of bromoenynes bearing an aryl group with catalytic amounts of palladium(II) acetate and cesium carbonate led to the direct construction of tri- or tetracyclic heterocycles. Direct arylation of a pyrrole, furan or thiophene ring i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527187b9e1514d5901ef5edc3cb1401e
http://hdl.handle.net/2433/158034
http://hdl.handle.net/2433/158034
Publikováno v:
Organic Letters. 13:2674-2677
A novel photochemical C-H carbamoylation of an octahydroisoindole derivative with PhNCO has allowed the authors to provide a unique access to a highly functionalized proline motif from which total synthesis of (±)-kainic acid, a bioactive marine alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986a2b76da7c58f51055fb1da928c26
https://doi.org/10.1021/ol200772f
https://doi.org/10.1021/ol200772f
Autor:
Naoto Kojima, Tetsuaki Tanaka, Takekuni Morioka, Takao Yamori, Naoyoshi Maezaki, Daisuke Urabe, Yuki Suga, Ayako Ohashi-Kobayashi, Masahiro Yano, Masatomo Maeda, Takehiko Yoshimitsu, Yasuyuki Fujimoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8630-8641
The convergent synthesis of fluorescence-labeled solamin, an antitumor Annonaceous acetogenin, was accomplished by two asymmetric alkynylations of 2,5-diformyl tetrahydrofuran with an alkyne tagged with fluorescent groups and another alkyne with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b3703957159d766226bc525a64b992
https://doi.org/10.1016/j.bmc.2010.10.004
https://doi.org/10.1016/j.bmc.2010.10.004
Publikováno v:
The Journal of Organic Chemistry. 75:5425-5437
The enantioselective total synthesis of (+)-hexachlorosulfolipid, a cytotoxin found in the Adriatic mussel Mytilus galloprovincialis, is described. The unique chlorinated hydrocarbon motif of the lipid is successfully furnished by a series of dichlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12188664c4a2f3818f66567904de99db
https://doi.org/10.1021/jo100534d
https://doi.org/10.1021/jo100534d
Publikováno v:
The Journal of Organic Chemistry. 75:3396-3400
A novel palladium(0)-catalyzed domino cyclization of 2-alkynylaziridines with isocyanates through ring expansion is described. Treatment of N-protected 2-(4-aminobut-1-ynyl)aziridine derivatives with a catalytic amount of Pd(PPh(3))(4) and aryl isocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04d11e83b7516a3149ec39a7e7e178c
https://doi.org/10.1021/jo100462w
https://doi.org/10.1021/jo100462w
Publikováno v:
Synlett. 2009:3171-3174
A one-pot convenient access to chiral 2-oxazolidinones is described. Diethylzinc-mediated asymmetric alkynylation of aldehydes with propiolates in the presence of β-sulfonamide alcohol as the chiral ligand, followed by treatment with isocyanates, yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6d55e761d89cb4fcc0d7eb9a729d0e
https://doi.org/10.1055/s-0029-1218353
https://doi.org/10.1055/s-0029-1218353