Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Tetsu Saito"'
Autor:
Akihiko Kimura, Jun Miyanohara, Mako Numazaki, Tetsu Saito, Hiroshi Suzuki, Masashi Maeda, Kazunori Arai, Yuji Saita, Masaki Abe, Emiko Imamura, Kaori Hanaoka
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 380:26-33
Thymic stromal lymphopoietin (TSLP), positioned at the top of the inflammatory cascade, is a key regulator that enhances allergic inflammatory responses by activating T helper type 2 (Th2) cells, Group 2 innate lymphoid cells (ILC2), and myeloid dend
Autor:
Tetsu Saito, Koshichiro Mitsukuni
Publikováno v:
IEEJ Transactions on Electronics, Information and Systems. 139:944-951
Autor:
Noriko Katori, Jun Hosogi, Kenta Kadotsuji, Kazuhiro Nishimiya, Tamiki Mori, Masako Soma, Kyoko Minoura, Muneo Aoyama, Tatsuki Nomura, Hiroko Shibata, Hiroki Wakabayashi, Takahiro Nakamura, Kazuko Nishimura, Akiko Ishii-Watabe, Yoshiro Saito, Norihisa Sakamoto, Shingo Niimi, Tetsu Saito
Publikováno v:
Bioanalysis. 11:509-524
Aim: Appropriateness of anti-drug antibody (ADA) assay is critical for immunogenicity assessment of biopharmaceuticals. Although cut point setting in ADA assay has a large impact on the results, a standard statistical approach for its setting has not
Autor:
Katsunari Taguchi, Akira Imasato, Tatsuaki Morokata, Tetsu Saito, Haruna Sasaki-Iwaoka, Kyoko Minoura, Satoshi Kubo, Emiko Imamura, Kiyoshi Kushima, Shigetada Furukawa, Makoto Ohori
Publikováno v:
European Journal of Pharmacology. 828:89-96
Interleukin (IL)-12 and IL-23 share a common subunit (p40) and function in T-helper (Th) 1 and Th17 immunity, respectively. Anti-IL-12/23p40 and specific anti-IL-23 antibodies are currently in clinical use for psoriasis and undergoing trials for auto
Autor:
Tetsu Saito, Ken-ichi Yamamoto, Hideki Harada, Kazuhiro Nishimiya, Masanobu Nishidate, Hiroko Shigemizu, Nana Kawasaki, Tsutomu Hashimoto, Kazuhiko Sonehara, Itadaki Yamaguchi, Akiko Ishii-Watabe, Tatsuki Nomura, Jin Shimakura, Kenta Kadotsuji, Takahiro Nakamura, Jun Hosogi, Kyoko Minoura, Shingo Niimi, Tamiki Mori, Maiko Adachi
Publikováno v:
Drug metabolism and pharmacokinetics. 33(2)
This study was undertaken to evaluate the performance of anti-drug antibody (ADA) assays constructed by each participating company using common samples including ADA, drug and human serum. The ADA assays constructed by each company showed good sensit
Publikováno v:
IEEJ Transactions on Electronics, Information and Systems. 134:737-746
Autor:
Kazunori Arai, Mako Numazaki, Shigetada Furukawa, Emiko Imamura, Satoshi Kubo, Hiroshi Suzuki, Kaori Hanaoka, Fujiko Takamura, Masashi Maeda, Tetsu Saito
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:AB13
Autor:
Keiji Miyata, Kazumi Hayashi, Tomihisa Kawasaki, Tetsu Saito, Jun Takasaki, Yumiko Moritani, Masatoshi Taniguchi, Wataru Uchida, Toshio Uemura
Publikováno v:
British Journal of Pharmacology. 148:61-69
1 The effects of YM-254890, a specific Galpha(q/11) inhibitor, on platelet functions, thrombus formation under high-shear rate condition and femoral artery thrombosis in cynomolgus monkeys were investigated. 2 YM-254890 concentration dependently inhi
Autor:
Koji Nagai, Kazumi Hayashi, Tomihisa Kawasaki, Masatoshi Taniguchi, Toshio Uemura, Jun Takasaki, Tetsu Saito, Yumiko Moritani, Takeshi Shigenaga, Hajime Takamatsu
Publikováno v:
Thrombosis and Haemostasis. 94:184-192
SummaryThe pharmacological properties of YM-254890,a specific Gαq/11 inhibitor, on acute thrombosis and chronic neointima formation after vascular injury have been investigated. FeCl3 was used to induce vascular injury in the carotid artery of mice.
Autor:
Takahide Ohishi, Hitoshi Matsushime, Tetsu Saito, Takatoshi Soga, Masazumi Kamohara, Kiyoshi Furuichi, Masato Kobori, Mitsuyuki Matsumoto, Shunichiro Matsumoto, Hideki Hiyama, Jun Takasaki, Tetsuo Matsui, Kazuhiro Momose, Yoshitaka Ueda, Shigeru Yoshida
Publikováno v:
Biochemical and Biophysical Research Communications. 326:744-751
A lysophospholipid series, such as lysophosphatidic acid, lysophosphatidylserine, and lysophosphatidylcholine (LPC), is a bioactive lipid mediator with diverse physiological and pathological functions. LPC has been reported to induce insulin secretio