Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tetsu Kawabata"'
Autor:
Gen Kuroyanagi, Haruhiko Tokuda, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Woo Kim, Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth factor-β (TGF-β), the
Externí odkaz:
https://doaj.org/article/d7dab7483c244fb296d6568b40a34bef
Autor:
Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling factor, induces the
Externí odkaz:
https://doaj.org/article/aa50c6de43b44762b74f761572db8ea6
Autor:
Gen Kuroyanagi, Junko Tachi, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Daiki Nakashima, Woo Kim, Kumiko Tanabe, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Interleukin-6 (IL-6) is a pro-inflammatory and bone-resorptive cytokine that also regulates bone formation. We previously showed that prostaglandin E1 (PGE1) induces the synthesis of IL-6 by activating p44/p42 mitogen-activated protein kinase (MAPK),
Externí odkaz:
https://doaj.org/article/87a922416b5041e3a5590c0733185f28
Autor:
Woo Kim, Kumiko Tanabe, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Junko Tachi, Tomoyuki Hioki, Daiki Nakashima, Shinobu Yamaguchi, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Publikováno v:
Heliyon, Vol 6, Iss 8, Pp e04779- (2020)
Osteoprotegerin (OPG) synthesized by osteoblasts is currently considered a crucial regulator to suppress the formation and function of osteoclasts. We previously showed that the synthesis of OPG is stimulated by prostaglandin F2α (PGF2α) in the inv
Externí odkaz:
https://doaj.org/article/87d544ee505e40fa9018607e7ff1e5e8
Autor:
Go Sakai, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Publikováno v:
Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 1133-1145 (2017)
Background/Aims: We previously demonstrated that transforming growth factor-β (TGF-β) stimulates the synthesis of vascular endothelial growth factor (VEGF) through the activation of p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T
Externí odkaz:
https://doaj.org/article/02850ff262e449a0a5547a66109f1db6
Autor:
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Publikováno v:
Cellular Physiology and Biochemistry, Vol 43, Iss 3, Pp 1025-1036 (2017)
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced mig
Externí odkaz:
https://doaj.org/article/a6405726c8c140bea62c1fb1820df080
Autor:
Kazuhiko Fujita, Haruhiko Tokuda, Gen Kuroyanagi, Naohiro Yamamoto, Shingo Kainuma, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177878 (2017)
Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, is recognized to be a major molecular chaperone. We have previously reported that prostaglandin F2α (PGF2α), a potent bone remodeling mediator, stimulates the synthesi
Externí odkaz:
https://doaj.org/article/6b7fafd8efb647cfbcdb81192059a96c
Autor:
Tetsu Kawabata, Haruhiko Tokuda, Go Sakai, Kazuhiko Fujita, Rie Matsushima-Nishiwaki, Gen Kuroyanagi, Takanobu Otsuka, Osamu Kozawa
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 109 (2018)
Heat shock protein 70 (HSP70) is a ubiquitously expressed molecular chaperone in a variety of cells including osteoblasts. We previously showed that insulin-like growth factor-I (IGF-I) elicits migration of osteoblast-like MC3T3-E1 cells through the
Externí odkaz:
https://doaj.org/article/90a5979c57694f3abf1b2a1aa92b7237
Autor:
Kazuhiko Fujita, Tomoyuki Hioki, Haruhiko Tokuda, Takanobu Otsuka, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Tetsu Kawabata, Woo Kim, Osamu Kozawa, Hiroki Iida, Go Sakai
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 84:2428-2439
Resveratrol is a natural polyphenol with beneficial antioxidant properties. It suppresses the migration of osteoblast-like MC3T3-E1 cells induced by epidermal growth factor, via SIRT1-mediated inhibition of SAPK/JNK and Akt. Moreover, insulin-like gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fff804e6cd0b1e8d3f72b005f8dd8f5
https://doi.org/10.1080/09168451.2020.1809987
https://doi.org/10.1080/09168451.2020.1809987
Autor:
Tomoyuki Hioki, Gen Kuroyanagi, Kazuhiko Fujita, Go Sakai, Tetsu Kawabata, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 54(1)
Incretins including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), which are secreted from the small intestine after oral food ingestion, are currently well-known to stimulate insulin secretion from pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c46cebd72f4227a0f0bbda5a1cea920
https://pubmed.ncbi.nlm.nih.gov/34986499
https://pubmed.ncbi.nlm.nih.gov/34986499