Zobrazeno 1 - 10 of 318 pro vyhledávání: '"Tetsu, Yano"'
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Akademický článek
Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas.
Autor: Yuriko Uehara, Katsutoshi Oda, Yuji Ikeda, Takahiro Koso, Shingo Tsuji, Shogo Yamamoto, Kayo Asada, Kenbun Sone, Reiko Kurikawa, Chinami Makii, Otoe Hagiwara, Michihiro Tanikawa, Daichi Maeda, Kosei Hasegawa, Shunsuke Nakagawa, Osamu Wada-Hiraike, Kei Kawana, Masashi Fukayama, Keiichi Fujiwara, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128066 (2015)
Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical outcome, even with early diagnosis; whereas high-grade serous carcinomas (SCs) and endometrioid carcinomas (ECs) are commonly chemosensitive at advanced
Externí odkaz: https://doaj.org/article/8696fc5f5aa2451ca291a478c02441b4
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4
Akademický článek
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.
Autor: Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirota, Kanako Inaba, Chinami Makii, Reiko Kurikawa, Aki Miyasaka, Takahiro Koso, Tomohiko Fukuda, Michihiro Tanikawa, Keiko Shoji, Kenbun Sone, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Shunsuke Nakagawa, Koichi Matsuda, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87220 (2014)
DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and
Externí odkaz: https://doaj.org/article/ef12b6d8423a437b933c13dd9570c13b
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5
Akademický článek
A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.
Autor: Kazunori Nagasaka, Takayuki Seiki, Aki Yamashita, Paola Massimi, Vanitha Krishna Subbaiah, Miranda Thomas, Christian Kranjec, Kei Kawana, Shunsuke Nakagawa, Tetsu Yano, Yuji Taketani, Tomoyuki Fujii, Shiro Kozuma, Lawrence Banks
Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53752 (2013)
Previous studies have shown that the cell polarity regulator hScrib interacts with, and consequently controls, the ERK signaling pathway. This interaction occurs through two well-conserved Kinase Interacting Motifs, which allow hScrib to bind ERK1 di
Externí odkaz: https://doaj.org/article/45f0a6cc2a42441295e27e347cd5a114
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6
Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism
Autor: Misao Nakanishi, Mamoru Tanaka, Takao Nammo, Nobuaki Funahashi, Hideoki Fukuoka, Yuichi Sato, Kazuki Yasuda, Tetsu Yano, Shigeki Minoura, H. Yoshihara, Hajime Oishi, Norihiro Kato
Publikováno v: The journal of obstetrics and gynaecology researchReferences. 47(2)
AIM We performed a birth cohort study involving 124 mother-infant pairs to investigate whether placental DNA methylation is associated with maternal choline status and fetal development. METHODS Plasma choline concentration was assayed longitudinally
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5977ee4fa4a6481fa3e5bdb6ddc46b79
https://pubmed.ncbi.nlm.nih.gov/33300271
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7
Akademický článek
Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.
Autor: Keiko Shoji, Katsutoshi Oda, Tomoko Kashiyama, Yuji Ikeda, Shunsuke Nakagawa, Kenbun Sone, Yuichiro Miyamoto, Haruko Hiraike, Michihiro Tanikawa, Aki Miyasaka, Takahiro Koso, Yoko Matsumoto, Osamu Wada-Hiraike, Kei Kawana, Hiroyuki Kuramoto, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Shiro Kozuma, Yuji Taketani
Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37431 (2012)
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235--a dual PI3K/m
Externí odkaz: https://doaj.org/article/deba6ac38326495e940cd4b60e0f2bad
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9
The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis
Autor: Nana Akino, Yoshihiro Morita, Mana Hirano, Kei Kawana, Yoshihiro Nishi, Houju Fu, Hajime Oishi, Kaori Koga, Yutaka Osuga, Wataru Isono, Tomoyuki Fujii, Tomohiko Fukuda, Ayako Sakurabashi, Miyuki Harada, Tetsu Yano, Katsutoshi Oda, Michihiro Tanikawa, Toshihiko Yanase, Yuichiro Miyamoto, Osamu Wada-Hiraike
Publikováno v: Reproductive Sciences. 24:133-141
Germline mutations of the fork-head transcriptional factor forkhead box L2 (FOXL2) predispose embryos to autosomal-dominant blepharophimosis-ptosis-epicanthus inversus syndrome with primary ovarian insufficiency in female patients, but the mechanisms
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591e17f04877c0c6d995de44ebb06a1b
https://doi.org/10.1177/1933719116651150
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