Zobrazeno 1 - 10 of 1 928 pro vyhledávání: '"Tetrahydrouridine"'
1
Akademický článek
Pharmacokinetics and pharmacodynamics of an oral formulation of decitabine and tetrahydrouridine.
Autor: Lau H; EpiDestiny, Inc., Akron, Ohio, USA., Woost PG; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Friedrich U; Precision Medicine, Biomarkers & Diagnostic Centre of Expertise, Novo Nordisk A/S, Søborg, Denmark., Clausen WHO; Precision Medicine, Biomarkers & Diagnostic Centre of Expertise, Novo Nordisk A/S, Søborg, Denmark., Jacobberger JW; Cleveland Cytometry Services Company, Novelty, Ohio, USA., Saunthararajah Y; Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio, USA.
Publikováno v: European journal of haematology [Eur J Haematol] 2023 Sep; Vol. 111 (3), pp. 345-355. Date of Electronic Publication: 2023 Jul 07.
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2
Akademický článek
In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters
Autor: Säll, Carolina a, ⁎, Koncsos, Gábor b, Klukovits, Anna b
Publikováno v: In Journal of Pharmaceutical Sciences October 2023 112(10):2676-2684
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5
Akademický článek
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6
Akademický článek
Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
Autor: Molokie R; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America., Lavelle D; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America., Gowhari M; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Pacini M; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Krauz L; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Hassan J; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Ibanez V; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America., Ruiz MA; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America., Ng KP; Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America., Woost P; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America., Radivoyevitch T; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America., Pacelli D; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Fada S; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America., Rump M; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America., Hsieh M; Molecular and Clinical Hematology Section, National Institutes of Health, Bethesda, Maryland, United States of America., Tisdale JF; Molecular and Clinical Hematology Section, National Institutes of Health, Bethesda, Maryland, United States of America., Jacobberger J; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America., Phelps M; College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America., Engel JD; Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America., Saraf S; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Hsu LL; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Gordeuk V; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., DeSimone J; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America., Saunthararajah Y; Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
Publikováno v: PLoS medicine [PLoS Med] 2017 Sep 07; Vol. 14 (9), pp. e1002382. Date of Electronic Publication: 2017 Sep 07 (Print Publication: 2017).
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7
Akademický článek
Intravenous 5-fluoro-2'-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors.
Autor: Coyne GO'; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Wang L; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Zlott J; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Juwara L; Clinical Monitoring Research Program, Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Covey JM; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Beumer JH; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Cristea MC; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA., Newman EM; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA., Koehler S; City of Hope Medical Group, South Pasadena, CA, USA., Nieva JJ; University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Garcia AA; University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.; Louisiana State University, New Orleans, LA, 70112, USA., Gandara DR; University of California Davis Cancer Center, Sacramento, CA, USA., Miller B; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Khin S; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Miller SB; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Steinberg SM; Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Rubinstein L; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Parchment RE; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Kinders RJ; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Piekarz RL; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Kummar S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Chen AP; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA., Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, 31 Center Drive, Bldg. 31 Room 3A-44, Bethesda, MD, 20892, USA. doroshoj@mail.nih.gov.; Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. doroshoj@mail.nih.gov.
Publikováno v: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2020 May; Vol. 85 (5), pp. 979-993. Date of Electronic Publication: 2020 Apr 20.
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9
Akademický článek
Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.
Autor: Morfouace M; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Nimmervoll B; CR UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge, CB2 ORE, UK., Boulos N; CR UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge, CB2 ORE, UK., Patel YT; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Shelat A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Freeman BB 3rd; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Robinson GW; Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Wright K; Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Gajjar A; Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Stewart CF; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. clinton.stewart@stjude.org., Gilbertson RJ; CR UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge, CB2 ORE, UK. richard.gilbertson@cruk.com.ac.uk., Roussel MF; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. martine.roussel@stjude.org.
Publikováno v: Journal of neuro-oncology [J Neurooncol] 2016 Jan; Vol. 126 (2), pp. 225-34. Date of Electronic Publication: 2015 Oct 30.
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10
Akademický článek
Biodistribution, Tumor Detection, and Radiation Dosimetry of 18 F-5-Fluoro-2'-Deoxycytidine with Tetrahydrouridine in Solid Tumors.
Autor: Young CR; Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Maryland., Adler S; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick, Maryland., Eary JF; Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Lindenberg ML; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Jacobs PM; Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Collins J; Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and., Kummar S; Stanford University School of Medicine, Palo Alto, California., Kurdziel KA; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Choyke PL; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Mena E; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland esther.menagonzalez@nih.gov.
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2019 Apr; Vol. 60 (4), pp. 492-496. Date of Electronic Publication: 2018 Nov 02.
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