Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Tetracycline-inducible"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The study of cooperating genes in cancer can lead to mechanistic understanding and identifying potential therapeutic targets. To facilitate these types of studies, we developed a new dual-inducible system utilizing the tetracycline- and cuma
Externí odkaz:
https://doaj.org/article/719a273eb57744c19687fba4bd3a70be
Akademický článek
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Publikováno v:
Animal Microbiome, Vol 3, Iss 1, Pp 1-11 (2021)
Abstract Background For more than 30 years, the tetracycline on/off system of inducible gene expression has been leveraged to study disease mechanisms across many research areas, especially that of metabolism and neuroscience. This system requires ac
Externí odkaz:
https://doaj.org/article/cb6b2773b8e840998cdee2e613c95bc2
Publikováno v:
Genes, Vol 13, Iss 10, p 1679 (2022)
Tetracycline-inducible systems are widely used control elements for mammalian gene expression. Despite multiple iterations to improve inducibility, their use is still compromised by basal promoter activity in the absence of tetracyclines. In a mammal
Externí odkaz:
https://doaj.org/article/80a115dac22c49138777f8fa623caa28
Publikováno v:
AMB Express, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The generation of conditional mutants has been an effective approach to studying bacteria and validating drug targets, and mutants of Mycobacteria are no exception. However unlike other bacteria, there is still a paucity of available tools f
Externí odkaz:
https://doaj.org/article/b06fcb4fc7f7480cb1ad6eff264032bf
Autor:
Susan Zhou, Zhengping Jia
Publikováno v:
Cells, Vol 10, Iss 11, p 3010 (2021)
P21-activated kinase 3 (PAK3) gene mutations are linked to several neurodevelopmental disorders, but the underlying mechanisms remain unclear. In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) p
Externí odkaz:
https://doaj.org/article/0285c174aed64877b54cc913a28d88c5
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-9 (2017)
Abstract Background Lipoic acid is a cofactor for α-keto acid dehydrogenase system that is involved in the central energy metabolism. In the apicomplexan parasite, Plasmodium, lipoic acid protein ligase 1 (LplA1) and LplA2 catalyse the ligation of a
Externí odkaz:
https://doaj.org/article/63948962b91745ff94c552307128bb03
Akademický článek
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Autor:
Benjamin, Laura E., Keshet, Eli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Aug 01. 94(16), 8761-8766.
Externí odkaz:
https://www.jstor.org/stable/42931
Autor:
Ren-Yu Zhang, Ding Wei, Ze-Kun Liu, Yu-Le Yong, Wei Wei, Zhi-Yun Zhang, Jian-Jun Lv, Zhao Zhang, Zhi-Nan Chen, Huijie Bian
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Chimeric antigen receptor T cell (CAR-T) therapy to hematological malignancies has demonstrated tremendous clinical outcomes. However, the therapeutic efficacy of CAR-T cells in solid tumors remains limited due to the scarcity of tumor-specific antig
Externí odkaz:
https://doaj.org/article/e7ba422ef56942babe180b4104e8dfbd