The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo

Autor: Tet Matsuguchi, Elizabeth Blackburn

Publikováno v: PeerJ, Vol 4, p e1534 (2016)

Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized. He

Externí odkaz: https://doaj.org/article/c6f87d549cc74d619847c817b7505cce

Metabolic profiles of biological aging in American Indians: The strong heart family study

Autor: Elizabeth H. Blackburn, Tianwei Yu, Tet Matsuguchi, Karan Uppal, Elisa T. Lee, Jue Lin, Jinying Zhao, Barbara V. Howard, ViLinh Tran, Dean P. Jones, Yun Zhu

Publikováno v: Scopus-Elsevier
Aging (Albany NY)

Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6be5423369045a2362cc03123c405c9
https://doi.org/10.18632/aging.100644

QTL mapping of leukocyte telomere length in American Indians: The Strong Heart Family Study

Autor: Elisa T. Lee, Yun Zhu, Jue Lin, Lyle G. Best, Jean W. MacCluer, Tet Matsuguchi, Shelley A. Cole, Elizabeth H. Blackburn, V. Saroja Voruganti, Jinying Zhao

Publikováno v: Blackburn, Elizabeth; Zhu, Y; Voruganti, VS; Lin, J; Matsuguchi, T; Best, LG; et al.(2013). QTL mapping of leukocyte telomere length in American Indians: The strong heart family study. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2nq5z80v
Scopus-Elsevier
Aging (Albany NY)

Telomeres play a central role in cellular senescence and are associated with a variety of age-related disorders such as dementia, Alzheimer's disease and atherosclerosis. Telomere length varies greatly among individuals of the same age, and is herita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fabeef634560103c751ba748c7894b1
https://doi.org/10.18632/aging.100600

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Autor: Tet Matsuguchi, Marcin Paduch, Megan McLaughlin, Michael Hornsby, Zhijian Li, Shohei Koide, Rachel Hanna, James A. Wells, Sachdev S. Sidhu, Annika Sääf, Shane Miersch, Anthony A. Kossiakoff

Publikováno v: Journal of Visualized Experiments.

The demand for antibodies that fulfill the needs of both basic and clinical research applications is high and will dramatically increase in the future. However, it is apparent that traditional monoclonal technologies are not alone up to this task. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b80c8ac894ba15733afab7eadf0818
https://doi.org/10.3791/51492-v

Abstract P012: Short Leukocyte Telomere Length is Associated With Obesity in American Indians: The Strong Heart Family Study

Autor: Shufeng Chen, Jue Lin, Tet Matsuguchi, Elizabeth Blackburn, Elisa T Lee, Barbara V Howard, Jinying Zhao

Publikováno v: Circulation. 129

Background: Obesity is an independent risk factor for diabetes and cardiovascular disease. Telomere length shortens progressively with age, and shorter leukocyte telomere length (LTL) has been associated with a wide range of age-related disorders. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a2b7ff4dab13c679e6f8ea04ef8c53c
https://doi.org/10.1161/circ.129.suppl_1.p012