Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression

Autor: Rong Ju, Min Gong, Yu Zhou, Yingfei Lu, Jianquan Chen

Publikováno v: Journal of Endocrinology. 251:69-81

Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially on pancreatic beta cell function, is rarely investigated. Our current study ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35987c9e14c57b2d5b38faa87068a4c4
https://doi.org/10.1530/joe-21-0129

SUN-015 Developmental Programming: Depot-Specific Inflammatory State and Distribution of Thermogenic Adipocytes Programmed by Gestational Testosterone Excess

Autor: Joseph N. Ciarelli, Vasantha Padmanabhan, Muraly Puttabyatappa

Publikováno v: Journal of the Endocrine Society

Prenatal testosterone excess induces insulin resistance, dyslipidemia and cardiovascular defects in ewes. Considering adipose depots influence systemic metabolic status, disruptions in visceral (VAT), subcutaneous (SAT), pericardiac (PCAT) and perire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed75c205ea31f78beb9af342ab391f6
https://doi.org/10.1210/jendso/bvaa046.1600

Developmental Programming: Impact of Prenatal Testosterone Excess on Steroidal Machinery and Cell Differentiation Markers in Visceral Adipocytes of Female Sheep

Autor: Jacob D. Martin, Muraly Puttabyatappa, Gregorio D. Chazenbalk, Chunxia Lu, Vasantha Padmanabhan, Daniel A. Dumesic

Publikováno v: Reproductive Sciences. 25:1010-1023

Prenatal testosterone (T)-treated female sheep manifest reduced adipocyte size and peripheral insulin resistance. The small adipocyte phenotype may reflect defects in adipogenesis and its steroidal machinery. To test whether prenatal T treatment from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913d5cea5f9609811f95437b4cb6e20d
https://doi.org/10.1177/1933719117746767

Postmenopausal Ovarian Hyperthecosis Associated with Rapid Testosterone Excess

Autor: M RothTed

Publikováno v: Journal of Gynecologic Surgery. 34:36-39

Background: Ovarian hyperthecosis (OH) is a rare cause of hyperandrogenism in postmenopausal women. Cases: This article reports 2 cases of postmenopausal women with recent onset hirsutism ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78fe24346180d1188df666012f847b38
https://doi.org/10.1089/gyn.2017.0038

Testosterone for Poor Ovarian Responders: Lessons From Ovarian Physiology

Autor: Francisca Martínez, Johan Smitz, Arne van der Vijver, Evangelos Evangelou, Christian De Geyter, Panagiotis Drakopoulos, Nikolaos P. Polyzos, Antonio Gosalvez Vega, Herman Tournaye, Susan R. Davis, Peter Humaidan, Pedro N. Barri

Publikováno v: Polyzos, N P, Davis, S R, Drakopoulos, P, Humaidan, P, De Geyter, C, Vega, A G, Martinez, F, Evangelou, E, van de Vijver, A, Smitz, J, Tournaye, H, Barri, P & T-TRANSPORT Investigators Group 2018, ' Testosterone for Poor Ovarian Responders : Lessons From Ovarian Physiology ', Reproductive Sciences, vol. 25, no. 7, pp. 980-982 . https://doi.org/10.1177/1933719116660849

Testosterone, an androgen that directly binds to the androgen receptor, has been shown in previous small randomized controlled trials to increase the reproductive outcomes of poor ovarian responders. In most of these studies, transdermal testosterone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c8a8b4f054e6ffda430aaeb2428a80
https://doi.org/10.1177/1933719116660849