Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Teston Kimberly Ann"'
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Autor:
Christian K. Sams, Lotte Bjerre Knudsen, Teston Kimberly Ann, Eugenia A. Iatsimirskaia, Anthony Lai Ling, Atsuo Kuki, Peter Madsen, Dan Kiel, Doug Murphy, Vlad E. Gregor, Jesper Lau, Javier Gonzalez, Christian L. Brand, Plewe Michael Bruno, John M. May, James Lakis, Shenghua Shi, Larry Kenneth Truesdale, Ulla G. Sidelmann, Alex Polinsky, Kenna Anderes
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
A series of alkylidene hydrazide derivatives containing an alkoxyaryl moiety was optimized. The resulting hydrazide-ethers were competitive antagonists at the human glucagon receptor. Pharmacokinetic experiments showed fast clearance of most of the c
Autor:
Madsen P; Department of Medicinal Chemistry, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark. pem@novonordisk.com, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2002 Dec 19; Vol. 45 (26), pp. 5755-75.