The molecular evolution of spermatogenesis across mammals

Autor: Svante Pääbo, Henrik Kaessmann, Thoomke Brüning, Frank Grützner, Philipp Khaitovich, Francesco Lamanna, Mari Sepp, Meritxell Riera Belles, Julia Schmidt, Katharina Mößinger, Christian Conrad, Rüdiger Behr, Celine Schneider, Ronald E. Bontrop, Sofia B. Winge, Kristian Almstrup, Timo Trefzer, Florent Murat, Ivanela Kondova, Margarida Cardoso-Moreira, Evgeny Leushkin, Noe Mbengue, Mikkel H. Schierup, Tomas Marques-Bonet

Publikováno v: Murat, F, Mbengue, N, Winge, S, Trefzer, T, Leushkin, E, Sepp, M, Cardoso-Moreira, M, Schmidt, J, Schneider, C, Mößinger, K, Brüning, T, Lamanna, F, Riera Belles, M, Conrad, C, Kondova, I, Bontrop, R, Behr, R, Khaitovich, P, Pääbo, S, Marques-Bonet, T, Grützner, F, Almstrup, K, Schierup, M H & Kaessmann, H 2023, ' The molecular evolution of spermatogenesis across mammals ', Nature .
Murat, F, Mbengue, N, Winge, S B, Trefzer, T, Leushkin, E, Sepp, M, Cardoso-Moreira, M, Schmidt, J, Schneider, C, Mößinger, K, Brüning, T, Lamanna, F, Belles, M R, Conrad, C, Kondova, I, Bontrop, R, Behr, R, Khaitovich, P, Pääbo, S, Marques-Bonet, T, Grützner, F, Almstrup, K, Schierup, M H & Kaessmann, H 2023, ' The molecular evolution of spermatogenesis across mammals ', Nature, vol. 613, pp. 308–316 . https://doi.org/10.1038/s41586-022-05547-7
Nature, 613. Nature Research
Nature

The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals1-6, probably owing to the evolutionary pressure on males to be reproductively successful7. However, the molecular evoluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5b94a7cb3b0894be247c9cbeae7eff

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

Autor: Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Müller-Sánchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X. Soriano, Ofelia M. Martínez-Estrada

Publikováno v: Torres-Cano, A, Portella-Fortuny, R, Müller-Sánchez, C, Porras-Marfil, S, Ramiro-Pareta, M, Chau, Y-Y, Reina, M, Soriano, F X & Martínez-Estrada, O M 2022, ' Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice ', PLoS Genetics, vol. 18, no. 6, e1010240 . https://doi.org/10.1371/journal.pgen.1010240

Assessing the role of the WT1 transcription factor (WT1) during early gonad differentiation and its impact on adult sex development has been difficult due to the complete gonadal agenesis and embryonic lethality exhibited by Wt1KO mouse models. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db39658a71f71b957dada7aa02d16478
https://www.pure.ed.ac.uk/ws/files/293752226/journal.pgen.1010240.pdf

Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism

Autor: Danyang Wang, Simone Hildorf, Elissavet Ntemou, Linn Salto Mamsen, Lihua Dong, Susanne Elisabeth Pors, Jens Fedder, Erik Clasen-Linde, Dina Cortes, Jørgen Thorup, Claus Yding Andersen

Publikováno v: Wang, D, Hildorf, S, Ntemou, E, Mamsen, L S, Dong, L, Pors, S E, Fedder, J, Clasen-Linde, E, Cortes, D, Thorup, J & Andersen, C Y 2022, ' Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism ', International Journal of Molecular Sciences, vol. 23, no. 14, 7975 . https://doi.org/10.3390/ijms23147975
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7975

Organotypic culture of human fetal testis has achieved fertilization-competent spermatids followed by blastocysts development. This study focuses on whether the organotypic culture of testicular tissue from infant boys with cryptorchidism could suppo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02bf2bf53cb60a7fcac428d3223baf5
https://curis.ku.dk/ws/files/315532771/ijms_23_07975_v2.pdf

Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism

Autor: Wiwat Rodprasert, Jaakko J Koskenniemi, Helena E Virtanen, Sergey Sadov, Antti Perheentupa, Helena Ollila, Jakob Albrethsen, Anna-Maria Andersson, Anders Juul, Niels E Skakkebaek, Katharina M Main, Jorma Toppari

Publikováno v: Rodprasert, W, Koskenniemi, J J, Virtanen, H E, Sadov, S, Perheentupa, A, Ollila, H, Albrethsen, J, Andersson, A-M, Juul, A, Skakkebaek, N E, Main, K M & Toppari, J 2022, ' Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 12, pp. 3353-3361 . https://doi.org/10.1210/clinem/dgac520

Context Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing. Objective We aimed to compare pubertal hormone l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a492464749a917841dc010a9008edeb
https://curis.ku.dk/portal/da/publications/reproductive-markers-of-testicular-function-and-size-during-puberty-in-boys-with-and-without-a-history-of-cryptorchidism(56ec2498-357b-48ed-b691-e081874cf24a).html

Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

Autor: Anders Juul, Klaus Brasso, Hanne Frederiksen, Martin Blomberg Jensen, John E. Nielsen, Hein Vincent Stroomberg, Anne Jørgensen, Martin Andreas Røder

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0238814 (2020)
PLoS ONE
Stroomberg, H V, Jørgensen, A, Brasso, K, Nielsen, J E, Juul, A, Frederiksen, H, Blomberg Jensen, M & Røder, M A 2020, ' Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients ', PLoS ONE, vol. 15, no. 9, e0238814 . https://doi.org/10.1371/journal.pone.0238814

Prostate cancer (PCa) cells become castrate-resistant after initial tumor regression following castration-based lowering of testosterone (T). De-novo intra-tumoral steroid synthesis is a suggested biological mechanism of castration resistant PCa, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a5f4dfd59dfe138d616c1abcb1d5cc
https://doaj.org/article/c14d32fadb2441119a34e5df62822512