Comparative Effects of Di( n -Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

Autor: Richard A. Anderson, Laura Kennedy, Chris McKinnell, Matthew S. Jobling, Ana Calarrao, Sander van den Driesche, Rod T. Mitchell, Richard M. Sharpe, Gary R. Hutchison, Lenka Hrabalkova, Sheila Macpherson

Publikováno v: van den Driesche, S, McKinnell, C, Calarrão, A, Kennedy, L, Hutchison, G R, Hrabalkova, L, Jobling, M S, Macpherson, S, Anderson, R A, Sharpe, R M & Mitchell, R T 2015, ' Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts ', Environmental Health Perspectives . https://doi.org/10.1289/ehp.1408248
Environmental Health Perspectives

Background Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the steroidogenic effects of phthalates, the effects on germ cells have been less e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8284b1d03703287da07e1e048ad22e9
https://doi.org/10.1289/ehp.1408248

Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling

Autor: Stylianos E. Antonarakis, Christel Thauvin-Robinet, Marilyn D. Resh, Laurence Faivre, Sandy Lambert, Isabelle Stévant, Christèle Desdoits-Lethimonier, Hiroshi Kurosaka, Paul A. Trainor, Federico Santoni, Christelle Borel, Bernard Jégou, Armine Matevossian, Antoine Rolland, Serge Nef, Frédéric Huet, Pierre Calvel, Françoise Kühne, Jadwiga Jaruzelska, Béatrice Conne, Patrick Callier, Séverine Mazaud-Guittot, Periklis Makrythanasis, Pascal Bernard, Céline Zimmermann, Michel Guipponi, Anne Vannier, Dagmar Wilhelm, Francine Mugneret

Publikováno v: PLoS Genet, vol. 10, no. 5, pp. e1004340
PLoS Genetics
PLoS Genetics, Public Library of Science, 2014, 10 (5), pp.e1004340. ⟨10.1371/journal.pgen.1004340⟩
PLOS Genetics, Vol. 10, No 5 (2014) P. e1004340
PLoS Genetics, Public Library of Science, 2014, 10 (5), pp.e1004340. 〈10.1371/journal.pgen.1004340〉
PLoS Genetics, Vol 10, Iss 5, p e1004340 (2014)
PLoS Genetics, 2014, 10 (5), pp.e1004340. ⟨10.1371/journal.pgen.1004340⟩

The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. Post-translational covalent attachment of cholesterol and palmitate to Hh proteins are critical for multime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd6b266f4ab586b836727c4f09cfaa
https://serval.unil.ch/resource/serval:BIB_359C54BAB25D.P001/REF.pdf

Temporal and spatial SOX9 expression patterns in the course of gonad development of the caudate amphibian Pleurodeles waltl

Autor: Dominique Chardard, Stéphane Flament, Sandra Kuntz, Amand Chesnel, Imane Al-Asaad, Hélène Dumond, Brigitte Boizet-Bonhoure

Publikováno v: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Wiley, 2011, 316B (3), pp.199-211. ⟨10.1002/jez.b.21390⟩

International audience; The SOX family of transcription factors is thought to regulate gene expression in a wide variety of developmental processes. Namely, SOX9 expression is conserved in vertebrate sex determination or differentiation. Nevertheless

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac28f3b4cc504106abee54005e2e94d
https://hal.archives-ouvertes.fr/hal-00747818

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