Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tessy Korthout"'
Autor:
Tessy Korthout, Deepani W Poramba-Liyanage, Ila van Kruijsbergen, Kitty F Verzijlbergen, Frank P A van Gemert, Tibor van Welsem, Fred van Leeuwen
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005542 (2018)
Transcription, replication, and repair involve interactions of specific genomic loci with many different proteins. How these interactions are orchestrated at any given location and under changing cellular conditions is largely unknown because systema
Externí odkaz:
https://doaj.org/article/0074c10b0715470d9cccd82434924638
Autor:
Hanneke Vlaming, Thom M Molenaar, Tibor van Welsem, Deepani W Poramba-Liyanage, Desiree E Smith, Arno Velds, Liesbeth Hoekman, Tessy Korthout, Sjoerd Hendriks, AF Maarten Altelaar, Fred van Leeuwen
Publikováno v:
eLife, Vol 5 (2016)
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious ass
Externí odkaz:
https://doaj.org/article/e595d7f77f3849ec8660431a9e2c8ef7
Autor:
Silke J.A. Lochs, Robin H. van der Weide, Kim L. de Luca, Tessy Korthout, Ramada E. van Beek, Hiroshi Kimura, Jop Kind
Gene expression programs result from the collective activity of many regulatory factors. To obtain insight into the mechanisms that govern gene regulation, it is imperative to study their combined mode of action and interconnectivity. However, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48ceea3792b260d90cd336cf2c83a74f
https://doi.org/10.1101/2023.01.18.524584
https://doi.org/10.1101/2023.01.18.524584
Autor:
Ila van Kruijsbergen, Tibor van Welsem, Christine E. Cucinotta, Fred van Leeuwen, Tessy Korthout, Deepani W. Poramba-Liyanage, Toshio Tsukiyama, Dris El Atmioui, Huib Ovaa
Publikováno v:
Genome Research, 30(4), 635-646. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Genome research, 30(4), 635-646. Cold Spring Harbor Laboratory Press
Genome Res
Genome research, 30(4), 635-646. Cold Spring Harbor Laboratory Press
Genome Res
Transcription of a chromatin template involves the concerted interaction of many different proteins and protein complexes. Analyses of specific factors showed that these interactions change during stress and upon developmental switches. However, how
Autor:
Teun van den Brand, Tibor van Welsem, Mir Farshid Alemdehy, Joke M. M. den Haan, Sjoerd Hendriks, Jannie Borst, Fred van Leeuwen, Muhammad Aslam, Tessy Korthout, Elzo de Wit, Heinz Jacobs, Cesare Lancini, Eliza Mari Kwesi-Maliepaard, Chelsea M. McLean, Tomasz Ahrends, Hanneke Vlaming, Dieke van Dinther
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20706-20716. National Academy of Sciences
Kwesi-Maliepaard, E M, Aslam, M A, Alemdehy, M F, Van Den Brand, T V, McLean, C, Vlaming, H, van Welsem, T, Korthout, T, Lancini, C, Hendriks, S, Ahrends, T, van Dinther, D, den Haan, J M M, Borst, J, de Wit, E, van Leeuwen, F & Jacobs, H 2020, ' The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 + T cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 34, pp. 20706-20716 . https://doi.org/10.1073/pnas.1920372117
Proceedings of the National Academy of Sciences, 117(34), 20706-20716. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20706-20716. National Academy of Sciences
Kwesi-Maliepaard, E M, Aslam, M A, Alemdehy, M F, Van Den Brand, T V, McLean, C, Vlaming, H, van Welsem, T, Korthout, T, Lancini, C, Hendriks, S, Ahrends, T, van Dinther, D, den Haan, J M M, Borst, J, de Wit, E, van Leeuwen, F & Jacobs, H 2020, ' The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 + T cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 34, pp. 20706-20716 . https://doi.org/10.1073/pnas.1920372117
Proceedings of the National Academy of Sciences, 117(34), 20706-20716. NATL ACAD SCIENCES
Significance Cytotoxic CD8+ T cells control infectious diseases as well as cancer. Memory T cells are a subset of CD8+ T cells that have previously encountered and rapidly responded to a specific antigen. Here we identified the epigenetic writer DOT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f4e0b0e06a07eb8799ed142a9ff0b7
https://hdl.handle.net/1887/3184225
https://hdl.handle.net/1887/3184225
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2049
The assembly and regulation of chromatin requires coordinated activity of multiple mechanisms. Many factors feed into signaling networks that control the epigenome of a cell. It is this complexity that makes understanding the layers of epigenetic reg
Autor:
Tessy Korthout, A. F. Maarten Altelaar, Eliza Mari Kwesi-Maliepaard, Liesbeth Hoekman, Sjoerd Hendriks, Sander Palit, Thierry Schmidlin, Heinz Jacobs, Mir Farshid Alemdehy, Jan Hermen Dannenberg, Sjoerd Klarenbeek, Fred van Leeuwen, Cesare Lancini, Tibor van Welsem, Chelsea M. McLean, Hanneke Vlaming, Thom M Molenaar
Publikováno v:
EMBO Journal, 38(14). Nature Publishing Group
The EMBO Journal
EMBO journal, 38(14):e101564. Wiley-Blackwell
The EMBO Journal
EMBO journal, 38(14):e101564. Wiley-Blackwell
DOT1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged leukemia. Inhibitors have been developed to target DOT1L activity in leukemia, but cellular mechanisms that regulate DOT1L are still poorly understood. We have identified
Publikováno v:
Methods in Molecular Biology ISBN: 9781493997350
Methods in Molecular Biology, 2049, 87-103
Methods in Molecular Biology, 2049, 87-103
The assembly and regulation of chromatin requires coordinated activity of multiple mechanisms. Many factors feed into signaling networks that control the epigenome of a cell. It is this complexity that makes understanding the layers of epigenetic reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918e4db954d41481aa63d69d25d26f65
https://doi.org/10.1007/978-1-4939-9736-7_5
https://doi.org/10.1007/978-1-4939-9736-7_5
Autor:
Haico van Attikum, Kirsten van Harten, Iris J. E. Stulemeijer, Trey Ideker, Rohith Srivas, Fred van Leeuwen, Su Ming Sun, Farid El Oualid, Hanneke Vlaming, Tineke L. Lenstra, Dominique Morais, Tibor van Welsem, Huib Ovaa, Frank C. P. Holstege, Tessy Korthout, Reggy Ekkebus, Deepani W. Poramba-Liyanage, Thom M Molenaar
Publikováno v:
Nucleic Acids Research
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca968c97e6ee05a0158c1e40575b5132
https://hdl.handle.net/1887/86410
https://hdl.handle.net/1887/86410
Autor:
Ila van Kruijsbergen, Deepani W. Poramba-Liyanage, Fred van Leeuwen, Frank P. A. van Gemert, Tibor van Welsem, Tessy Korthout, Kitty F. Verzijlbergen
Publikováno v:
PLoS biology, 16(7):e2005542. Public Library of Science
PLoS Biology, Vol 16, Iss 7, p e2005542 (2018)
PLoS Biology
PLoS Biology, Vol 16, Iss 7, p e2005542 (2018)
PLoS Biology
Transcription, replication, and repair involve interactions of specific genomic loci with many different proteins. How these interactions are orchestrated at any given location and under changing cellular conditions is largely unknown because systema