Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tessianna A. Misko"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 6 (2022)
Abstract Background: An important part of biomedical research is the translation of discoveries into clinical or community applications that impact patient health. For a vast majority of clinical applications and sustainable community interventions,
Externí odkaz:
https://doaj.org/article/9809c2e8666a4082b3748af3a7c48fe4
Autor:
Tessianna A. Misko, Yi-Ting Liu, Michael E. Harris, Nancy L. Oleinick, John Pink, Hsueh-Yun Lee, Chris G. Dealwis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 438-450 (2019)
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl h
Externí odkaz:
https://doaj.org/article/22676211cb304c0cb316d3ab05a629c9
Publikováno v:
Journal of clinical and translational science. 6(1)
Background: An important part of biomedical research is the translation of discoveries into clinical or community applications that impact patient health. For a vast majority of clinical applications and sustainable community interventions, a time-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e9ca2401de06b6c745dbea6d94fca4
https://pubmed.ncbi.nlm.nih.gov/35651959
https://pubmed.ncbi.nlm.nih.gov/35651959
Autor:
John J. Pink, Yi Ting Liu, Nancy L. Oleinick, Michael E. Harris, Tessianna A. Misko, Chris Dealwis, Hsueh Yun Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 438-450 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a425bfca344329b7652626689dc1c94d
https://doaj.org/article/22676211cb304c0cb316d3ab05a629c9
https://doaj.org/article/22676211cb304c0cb316d3ab05a629c9
Autor:
Masaru Miyagi, Suheel K. Porwal, Chris Dealwis, Andrew Zhang, Michael E. Harris, Rajesh Viswanathan, Tessianna A. Misko, Kay Perry, John J. Pink, Nancy L. Oleinick, Intekhab Alam, Md. Faiz Ahmad, Sarah E. Huff
Publikováno v:
Journal of Medicinal Chemistry. 58:9498-9509
Ribonucleotide reductase (RR) catalyzes the rate-limiting step of dNTP synthesis and is an established cancer target. Drugs targeting RR are mainly nucleoside in nature. In this study, we sought to identify non-nucleoside small-molecule inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35dbf5bfd979b94ea2c17122dec06c
https://doi.org/10.1021/acs.jmedchem.5b00929
https://doi.org/10.1021/acs.jmedchem.5b00929
Autor:
Donna S. Shewach, Chris Dealwis, William E. Harte, Faiz Ahmad, Tessianna A. Misko, Sarah E. Huff, Michael E. Harris, Sheryl A. Flanagan, John J. Pink, Intekhab Alam, Nancy L. Oleinick, Rajesh Viswanathan
Publikováno v:
Proc Natl Acad Sci U S A
Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728aec1d2236f266a043a79dd31b7e0
https://pubmed.ncbi.nlm.nih.gov/33168757
https://pubmed.ncbi.nlm.nih.gov/33168757
Autor:
Tessianna A. Misko, Anthony J. Berdis, Tomas Radivoyevitch, Michael E. Harris, Chris Dealwis, Sanath R. Wijerathna, Md. Faiz Ahmad
Publikováno v:
FEBS letters. 590(12)
Sml1 is an intrinsically disordered protein inhibitor of Saccharomyces cerevisiae ribonucleotide reductase (ScRR1), but its inhibition mechanism is poorly understood. RR reduces ribonucleoside diphosphates to their deoxy forms, and balances the nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ad7d91542db5eb9996f3180e137237
https://pubmed.ncbi.nlm.nih.gov/27155231
https://pubmed.ncbi.nlm.nih.gov/27155231
Autor:
Tessianna A. Misko, Liu, Yi-Ting, Harris, Michael E., Oleinick, Nancy L., Pink, John, Hsueh-Yun Lee, Dealwis, Chris G.
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee82118f2cc3e120b32114a21f7296ea
Autor:
Tessianna A. Misko, Liu, Yi-Ting, Harris, Michael E., Oleinick, Nancy L., Pink, John, Hsueh-Yun Lee, Dealwis, Chris G.
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008a5a97e880f0232f7262480db4888a