Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tessa V. van der Hoeven"'
Autor:
Geert A A Nibourg, Robert A F M Chamuleau, Tessa V van der Hoeven, Martinus A W Maas, An F C Ruiter, Wouter H Lamers, Ronald P J Oude Elferink, Thomas M van Gulik, Ruurdtje Hoekstra
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38778 (2012)
A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human bipotent liver progenitor cell line HepaRG is a promising candidate in this
Externí odkaz:
https://doaj.org/article/6c1861603e0d4671ab5f49e67411a5eb
Autor:
Gabrielle Plomer, Jurgen Seppen, R.O. Elferink, Thomas M. van Gulik, Mariëtte T. Ackermans, Robert A. F. M. Chamuleau, Ruurdtje Hoekstra, Tessa V. van der Hoeven, Geert A. A. Nibourg, Sandrine Camus, Wim Kulik
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 562-567. American Society for Pharmacology and Experimental Therapeutics
The human liver cell line HepaRG has been recognized as a promising source for in vitro testing of metabolism and toxicity of compounds. However, currently the hepatic differentiation of these cells relies on exposure to dimethylsulfoxide (DMSO), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832ddfa76d3550d6a0d79c84fa8aca98
https://doi.org/10.1124/dmd.112.049098
https://doi.org/10.1124/dmd.112.049098
Autor:
Jan H.J. Hoeijmakers, Timo M. Breit, Martijn E.T. Dollé, Gijsbertus T. J. van der Horst, Martijs J. Jonker, Joost P.M. Melis, Joke Robinson, Harry van Steeg, Raoul V. Kuiper, Paul F. K. Wackers, Tessa V. van der Hoeven, Jan Vijg
Publikováno v:
Aging Cell; Vol 12
Aging Cell, 12(5), 901-909
Aging Cell
European Research Council (ERC)
NARCIS
OpenAIRE
HEALTH FP7 Publications Database
Europe PubMed Central
Aging Cell, 12(5), 901. Wiley-Blackwell
Aging Cell, 12(5), 901-909. Wiley-Blackwell Publishing Ltd
Aging Cell, 12(5), 901-909. Wiley-Blackwell
Aging Cell, 12(5), 901-909
Aging Cell
European Research Council (ERC)
NARCIS
OpenAIRE
HEALTH FP7 Publications Database
Europe PubMed Central
Aging Cell, 12(5), 901. Wiley-Blackwell
Aging Cell, 12(5), 901-909. Wiley-Blackwell Publishing Ltd
Aging Cell, 12(5), 901-909. Wiley-Blackwell
Aging and age-related pathology is a result of a still incompletely-understood intricate web of molecular and cellular processes. We present a C57BL/6J female mice in vivo aging study of five organs (liver, kidney, spleen, lung and brain), in which w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a370819992b4a56eeac8d24cee2dd74
https://pure.eur.nl/en/publications/6a6186d3-683c-4c8f-bfe5-6c308032d6ca
https://pure.eur.nl/en/publications/6a6186d3-683c-4c8f-bfe5-6c308032d6ca
Autor:
Robert A. F. M. Chamuleau, Geert A. A. Nibourg, Thomas M. van Gulik, Ruurdtje Hoekstra, Mariëtte T. Ackermans, Tessa V. van der Hoeven, Theodorus B. M. Hakvoort
Publikováno v:
Liver international, 33(4), 516-524. Wiley-Blackwell
Background & Aims: The AMC-bioartificial liver loaded with the humanhepatoma cell line HepaRG as biocomponent (HepaRG-AMC-BAL) hasrecently proven efficacious in rats with acute liver failure (ALF). However, itsefficacy may be affected by cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76ee1678136227fe9b494cf8bc382a5
https://doi.org/10.1111/liv.12090
https://doi.org/10.1111/liv.12090
Autor:
Ruurdtje Hoekstra, Ronald P.J. Oude Elferink, Thomas M. van Gulik, Theodorus B. M. Hakvoort, Tessa V. van der Hoeven, Robert A. F. M. Chamuleau, Mariëtte T. Ackermans, Geert A. A. Nibourg
Publikováno v:
International journal of artificial organs, 35(11), 1006-1014. Wichtig Publishing
We recently demonstrated the high liver functionality of the human liver cell line HepaRG, including ammonia eliminating capacity, making it a valuable biocomponent of a bioartificial liver (BAL) to support patients with acute liver failure (ALF). Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb5a1da8f51bf1b982530a940eb46c
https://doi.org/10.5301/ijao.5000121
https://doi.org/10.5301/ijao.5000121
Autor:
Robert A. F. M. Chamuleau, Tessa V. van der Hoeven, Wouter H. Lamers, Ruurdtje Hoekstra, Thomas M. van Gulik, Mariëtte T. Ackermans, Geert A. A. Nibourg, Theodorus B. M. Hakvoort, Ronald P.J. Oude Elferink
Publikováno v:
international journal of biochemistry & cell biology, 43(10), 1483-1489. Elsevier Limited
For bioartificial liver application, cells should meet the following minimal requirements: ammonia elimination, drug metabolism and blood protein synthesis. Here we explore the suitability of HepaRG cells, a human cell line reported to differentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e1364076d0cdf78d46441943ff937f
https://doi.org/10.1016/j.biocel.2011.06.011
https://doi.org/10.1016/j.biocel.2011.06.011
Autor:
Maarten T. Huisman, Ruurdtje Hoekstra, Thomas M. van Gulik, Tessa V. van der Hoeven, Robert A. F. M. Chamuleau, Geert A. A. Nibourg
Publikováno v:
Liver Transplantation. 16:1075-1085
To bridge patients with acute liver failure to transplantation or liver regeneration, a bioartificial liver (BAL) is urgently needed. A BAL consists of an extracorporeal bioreactor loaded with a bioactive mass that would preferably be of human origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab4bfe1fecc7478758b0dfbf4eaddb1b
https://doi.org/10.1002/lt.22110
https://doi.org/10.1002/lt.22110
Autor:
Maarten van Iterson, Harry Vrieling, Martijs J. Jonker, Mirjam M. Schaap, Harry van Steeg, Tessa V. van der Hoeven, Annemieke de Vries, Oskar Bruning, Mirjam Luijten, Timo M. Breit, Rudolf B. Beems
Publikováno v:
Carcinogenesis, 30(10), 1805-1812. Oxford University Press
The carcinogenic potential of chemicals and pharmaceuticals is traditionally tested in the chronic, 2 year rodent bioassay. This assay is not only time consuming, expensive and often with a limited sensitivity and specificity but it also causes major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546c7c16c175a8d588d29067ff20332b
https://doi.org/10.1093/carcin/bgp190
https://doi.org/10.1093/carcin/bgp190
Autor:
Tessa V. van der Hoeven, Paul P.C. Poyck, Ruurdtje Hoekstra, Albert C.W.A. van Wijk, Robert A. F. M. Chamuleau, Ronald P.J. Oude Elferink, Dirk R. de Waart, Thomas M. van Gulik
Publikováno v:
Journal of hepatology, 48(2), 266-275. Elsevier
Background/Aims Clinical use of bioartificial livers (BAL) relies heavily on the development of human liver cell lines. The aim of this study was to assess the potential of the recently developed human fetal liver cell line cBAL111 for application in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da0cf84683f648630d1fab19d24b4f0
https://doi.org/10.1016/j.jhep.2007.09.018
https://doi.org/10.1016/j.jhep.2007.09.018
Autor:
Edwin P. Zwart, Martijs J. Jonker, Timo M. Breit, Tessa V. van der Hoeven, Annemieke de Vries, Wendy Bruins, Jeroen L. A. Pennings, Oskar Bruning, Han Rauwerda
Publikováno v:
Molecular and cellular biology, 28(6), 1974-1987. American Society for Microbiology
Molecular and Cellular Biology, 28(6), 1974-1987. American Society for Microbiology
Molecular and Cellular Biology, 28(6), 1974-1987. American Society for Microbiology
Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. Phosphorylation mutant p53.S389A cells and mice show reduced apoptosis and compromised tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85df52c04688a0c1ccf796a2657e2be1
https://doi.org/10.1128/mcb.01610-07
https://doi.org/10.1128/mcb.01610-07