Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tessa Nichols-Meade"'
Autor:
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols-Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas-Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez-Pastor
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. HTT mutation causes protein misfolding and aggregation, preferentially affecting
Externí odkaz:
https://doaj.org/article/0c91157893d74f8f80789769cd2bc31e
Autor:
Brennon O’Callaghan, Bente Hofstra, Hillary P. Handler, Holly B. Kordasiewicz, Tracy Cole, Lisa Duvick, Jillian Friedrich, Orion Rainwater, Praseuth Yang, Michael Benneyworth, Tessa Nichols-Meade, Wesley Heal, Rachel Ter Haar, Christine Henzler, Harry T. Orr
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 1006-1016 (2020)
Spinocerebellar ataxia type 1 (SCA1) is a lethal, autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in the ATAXIN-1 (ATXN1) protein. Preclinical studies demonstrate the therapeutic efficacy of approaches that target and
Externí odkaz:
https://doaj.org/article/15f7655d7b4b46cf81aff01299a0c211
Autor:
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols‑Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas‑Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez‑Pastor
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/fa1863ab67404351858fc15ac78a69b4
Autor:
Lisa Duvick, W. Michael Southern, Kellie Benzow, Hillary P. Handler, Jason S. Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie Scheeler, Orion Rainwater, Serres Shannah, Erin Larson, Tessa Nichols-Meade, Yun You, Brennon O’Callaghan, Huda Y. Zoghbi, James M. Ervasti, Marija Cvetanovic, Michael D. Koob, Harry T. Orr
Publikováno v:
bioRxiv
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ef39977231952db5f84fa6647e9d2
https://europepmc.org/articles/PMC9934664/
https://europepmc.org/articles/PMC9934664/
Autor:
Hillary P. Handler, Lisa Duvick, Jason S. Mitchell, Marija Cvetanovic, Molly Reighard, Alyssa Soles, Kathleen B. Mather, Orion Rainwater, Shannah Serres, Tessa Nichols-Meade, Stephanie L. Coffin, Yun You, Brian L. Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr
Publikováno v:
Neuron. 111:493-507.e6
Spinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and premature death. Degeneration of cerebellar Purkinje cells is a frequent and prominent pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae12659a358482226c7e82183d64359
https://doi.org/10.1016/j.neuron.2022.11.017
https://doi.org/10.1016/j.neuron.2022.11.017
Autor:
Hillary P. Handler, Lisa Duvick, Jason Mitchell, Marija Cvetanovic, Molly Reighard, Alyssa Soles, Orion Rainwater, Shannah Serres, Tessa Nichols-Meade, Stephanie L. Coffin, Yun You, Brian Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr
SUMMARYSpinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and premature death. Degeneration of cerebellar Purkinje cells is a frequent and promin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b0a7086a08ec6f57f5d9f58b01f2e7
https://doi.org/10.1101/2021.12.16.472987
https://doi.org/10.1101/2021.12.16.472987
Autor:
Michael A. Benneyworth, Elizabeth L Steuer, Tessa Nichols-Meade, Sarah N. Larson, Gregory J. Metzger, Ivan Tkáč, Kâmil Uğurbil
Publikováno v:
Magn Reson Med
Purpose The primary goal of this study was to investigate whether chronic exposures to ultra-high B0 fields can induce long-term cognitive, behavioral, or biological changes in C57BL/6 mice. Methods C57BL/6 mice were chronically exposed to 10.5-T or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3559388ad8ce7b1437cb5afae7563f84
https://pubmed.ncbi.nlm.nih.gov/33821502
https://pubmed.ncbi.nlm.nih.gov/33821502
Autor:
Hyuck Kim, Sarah N. Larson, Marija Cvetanovic, Katie Gundry, Kevin Jiang, Wei Tsai, Gülin Öz, Francesco Cuccu, Alfonso Araque, Rocío Gómez-Pastor, Michael A. Benneyworth, Dahyun Yu, Ying Zhang, Carmen Nanclares, Taylor G. Brown, José J. Lucas, Tessa Nichols-Meade, Rachel Mansky, Angel White, Cristina Tomás-Zapico, Nicole Zarate, Johnny S. Yue
BackgroundHuntington’s Disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. This mutation causes HTT protein misfolding and aggregation, preferentially aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d29b7de25225227fe1affb892c289b2
https://doi.org/10.1101/2020.10.29.359380
https://doi.org/10.1101/2020.10.29.359380
Autor:
Michael A. Benneyworth, Rachel Ter Haar, Holly Kordasiewicz, Jillian Friedrich, Orion Rainwater, Lisa A. Duvick, Wesley Heal, Praseuth Yang, Tessa Nichols-Meade, Tracy Cole, Bente Hofstra, Christine Henzler, Brennon L. O'Callaghan, Hillary P Handler, Harry T. Orr
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 1006-1016 (2020)
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 1006-1016 (2020)
Spinocerebellar ataxia type 1 (SCA1) is a lethal, autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in the ATAXIN-1 (ATXN1) protein. Preclinical studies demonstrate the therapeutic efficacy of approaches that target and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea4f084766562b635db139631308a91
https://pubmed.ncbi.nlm.nih.gov/32818920
https://pubmed.ncbi.nlm.nih.gov/32818920
Autor:
Brennon L. O'Callaghan, Zhao Chen, Harry T. Orr, H. Brent Clark, Holly B. Kordasiewicz, Bente Hofstra, Tessa Nichols-Meade, Hillary P Handler, Jillian Friedrich, Eric E. Swayze, Gülin Öz, Lisa A. Duvick, Michael A. Benneyworth, Carmen Wagener, Christine Henzler, Sarah N. Larson, Judit M. Pérez Ortiz, Huda Y. Zoghbi, Orion Rainwater, Praseuth Yang
Publikováno v:
JCI Insight. 3
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited ataxia caused by expansion of a translated CAG repeat encoding a glutamine tract in the ataxin-1 (ATXN1) protein. Despite advances in understanding the pathogenesis of SCA1, there are sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63165077c86ce3d5b6b369a097aad187
https://doi.org/10.1172/jci.insight.123193
https://doi.org/10.1172/jci.insight.123193