Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Tessa J Barrett"'
Autor:
Michael Peled, Hitoo Nishi, Ada Weinstock, Tessa J Barrett, Felix Zhou, Alexandra Quezada, Edward A Fisher
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173975 (2017)
Atherosclerosis can be induced by the injection of a gain-of-function mutant of proprotein convertase subtilisin/kexin type 9 (PCSK9)-encoding adeno-associated viral vector (AAVmPCSK9), avoiding the need for knockout mice models, such as low-density
Externí odkaz:
https://doaj.org/article/e22b88b89f024f4a956b9c97cb2c18fb
Autor:
Asif J Iqbal, Tessa J Barrett, Lewis Taylor, Eileen McNeill, Arun Manmadhan, Carlota Recio, Alfredo Carmineri, Maximillian H Brodermann, Gemma E White, Dianne Cooper, Joseph A DiDonato, Maryam Zamanian-Daryoush, Stanley L Hazen, Keith M Channon, David R Greaves, Edward A Fisher
Publikováno v:
eLife, Vol 5 (2016)
Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand the cellular and molecular basis of the anti-inflammatory actions of apoA1, we explo
Externí odkaz:
https://doaj.org/article/4f6ab8947a3d4308a252fadfcd67c3a6
Autor:
Fahd O Ismael, Tessa J Barrett, Diba Sheipouri, Bronwyn E Brown, Michael J Davies, Clare L Hawkins
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168844 (2016)
Low-density lipoprotein (LDL) is the major source of lipid within atherosclerotic lesions. Myeloperoxidase (MPO) is present in lesions and forms the reactive oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). These oxidants modify LD
Externí odkaz:
https://doaj.org/article/5154712134ee493eac4de4dae36a5460
Autor:
Maryem A Hussein, Elina Shrestha, Mireille Ouimet, Tessa J Barrett, Sarah Leone, Kathryn J Moore, Yann Hérault, Edward A Fisher, Michael J Garabedian
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135218 (2015)
High cholesterol and diabetes are major risk factors for atherosclerosis. Regression of atherosclerosis is mediated in part by the Liver X Receptor (LXR) through the induction of genes involved in cholesterol transport and efflux. In the context of d
Externí odkaz:
https://doaj.org/article/a1e482cac7ae4765bff7e34feef48b17
Autor:
MacIntosh G. Cornwell, Hanane El Bannoudi, Elliot Luttrell-Williams, Alexis Engel, Tessa J. Barrett, Khrystyna Myndzar, Peter Izmirly, H. Michael Belmont, Robert Clancy, Kelly V. Ruggles, Jill P. Buyon, Jeffrey S. Berger
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immune regulation highligh
Externí odkaz:
https://doaj.org/article/fb5af884d15f4bf08f9f2c71032c42be
Publikováno v:
Platelets, Vol 33, Iss 8, Pp 1208-1213 (2022)
Aspirin’s clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse. We investigated the influence of body weigh
Externí odkaz:
https://doaj.org/article/833a8e274c7e449ab1d5f47cb09da1bb
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Platelets, key facilitators of primary hemostasis and thrombosis, have emerged as crucial cellular mediators of innate immunity and inflammation. Exemplified by their ability to alter the phenotype and function of monocytes, activated platelets bind
Externí odkaz:
https://doaj.org/article/220de8b9fdbf46c79d661862b1fb2edb
Autor:
Alexander T. Fields, Elizabeth A. Andraska, Christof Kaltenmeier, Zachary A. Matthay, Kimberly Herrera, Brenda Nuñez-Garcia, Chayse M. Jones, Katherine D. Wick, Silvia Liu, Jian-Hua Luo, Yan-Ping Yu, Michael A. Matthay, Carolyn M. Hendrickson, Roland J. Bainton, Tessa J. Barrett, Jeffrey S. Berger, Matthew D. Neal, Lucy Z. Kornblith, the COVID-19 Associated Coagulopathy Inflammation and Thrombosis (Co-ACIT) Study Group, Biniam Ambachew;, Sarah Cary;, Lauren Chalwell;, Christopher Colwell;, Clayton Josephy;, Deanna Lee;, Matthieu LeGrand;, Juan Carlos Montoy;, Aaron E. Kornblith;, Philip Kurien;, Brenda Nunez-Garcia;, Viet Nguyen;, John J. Park;, Arun Prakash;, Brittany Robinson;, India Shelley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThromboinflammatory complications are well described sequalae of Coronavirus Disease 2019 (COVID-19), and there is evidence of both hyperreactive platelet and inflammatory neutrophil biology that contributes to the thromoinflammatory mili
Externí odkaz:
https://doaj.org/article/f9d1e7968ae74e3c854e8e76aeab2cc3
Autor:
Michael S. Garshick, Cyrus Nikain, Michael Tawil, Stephanie Pena, Tessa J. Barrett, Benjamin G. Wu, Zhan Gao, Martin J. Blaser, Edward A. Fisher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Since alterations in the intestinal microbiota may induce systemic inflammation and polarization of macrophages to the M1 state, the microbiome role in atherosclerosis, an M1-driven disease, requires evaluation. We aimed to determine if anti
Externí odkaz:
https://doaj.org/article/a8f3dfa3b18f42a5b4b2ebab1cb9df7e
Autor:
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in m
Externí odkaz:
https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd