Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tessa Huffstater"'
Autor:
Bradley I. Reinfeld, Andrew R. Patterson, Rachel E. Brown, Allison S. Cohen, Matthew H. Wilson, Anna Chytil, M. Noor Tantawy, Vera M. Todd, W. David Merryman, Jeffrey C. Rathmell, H. Charles Manning, Matthew G. Vander Heiden, Jackie E. Bader, Matthew Z. Madden, Abin Abraham, Alexander Muir, Frank M. Mason, Ahmed Ali, Christopher S. Williams, Richard T. O’Neil, Brian T. Do, Ayaka Sugiura, Tessa Huffstater, Kirsten Young, Rachelle W. Johnson, Caroline A. Lewis, Melissa M. Wolf, Emily F. Mason, Katherine E. Beckermann, W. Kimryn Rathmell, Fuxue Xin, Rachel Hongo
Publikováno v:
Nature. 593:282-288
Cancer cells characteristically consume glucose through Warburg metabolism1, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metab
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Autor:
David B. Chou, Rachelle Prantil-Baun, Ben Swenor, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Susan Marquez, Tessa Huffstater, Donald E. Ingber, Ben M. Maoz, Anna Herland, Michael J. Cronce, Yuka Milton, Angeliki Chalkiadaki, Miles Ingram, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Oren Levy, Sauveur S. F. Jeanty, Richard M. Novak, Aaron Delahanty, Kevin Kit Parker, Debarun Das
Publikováno v:
Nature Biomedical Engineering. 4:421-436
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Autor:
Melissa M. Wolf, AR Patterson, Tessa Huffstater, M. G. Vander Heiden, Bradley I. Reinfeld, Mohammed N. Tantawy, Matthew H. Wilson, Ahmed Ali, Abin Abraham, Alexander Muir, Vera M. Todd, Richard T. O’Neil, Caroline A. Lewis, Matthew Z. Madden, Anna Chytil, Kirsten Young, Christopher S. Williams, Rachelle W. Johnson, Katy Beckermann, Frank M. Mason, Jeffrey C. Rathmell, Merryman Wd, Rachel Hongo, Allison S. Cohen, Wendy Kimryn Rathmell, HC Manning, F Xin, Jackie E. Bader, Rachel E. Brown, Brian T. Do, Emily F. Mason
The tumor microenvironment (TME) includes transformed cancer and infiltrating immune cells1,2. Cancer cells can consume large quantities of glucose through Warburg metabolism3,4 that can be visualized with positron emission tomography (PET). While in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc0cdf9bf9ee828ee8c797cc0cfe8ad
https://doi.org/10.1101/2020.08.10.238428
https://doi.org/10.1101/2020.08.10.238428
Autor:
Bradley I, Reinfeld, Matthew Z, Madden, Melissa M, Wolf, Anna, Chytil, Jackie E, Bader, Andrew R, Patterson, Ayaka, Sugiura, Allison S, Cohen, Ahmed, Ali, Brian T, Do, Alexander, Muir, Caroline A, Lewis, Rachel A, Hongo, Kirsten L, Young, Rachel E, Brown, Vera M, Todd, Tessa, Huffstater, Abin, Abraham, Richard T, O'Neil, Matthew H, Wilson, Fuxue, Xin, M Noor, Tantawy, W David, Merryman, Rachelle W, Johnson, Christopher S, Williams, Emily F, Mason, Frank M, Mason, Katherine E, Beckermann, Matthew G, Vander Heiden, H Charles, Manning, Jeffrey C, Rathmell, W Kimryn, Rathmell
Publikováno v:
Signal Transduction and Targeted Therapy
Cancer cells characteristically consume glucose through Warburg metabolism
Autor:
W. David Merryman, Bradley I. Reinfeld, Meena S. Madhur, Brian R. Lindman, W. Kimryn Rathmell, Jeffrey C. Rathmell, Sabrina E. Booton, Matthew Z. Madden, Matthew R. Bersi, Michael A. Raddatz, Tessa Huffstater
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1 +/− model of calcific a
Autor:
Kenyi Saito-Diaz, Ethan Lee, Tessa Huffstater, Robert S. McMahon, Balakuntalam S. Kasinath, Surekha Neelisetty, Yosuke Osaki, Alla V. Ivanova, Makoto Mark Taketo, Jane Tonello, Raymond C. Harris, Lauren Scarfe, Stellor Nlandu-Khodo, Mark P. deCaestecker, Melanie Phillips-Mignemi, Haichun Yang, Leslie Gewin
Publikováno v:
JCI Insight
The Wnt/β-catenin signaling pathway plays an important role in renal development and is reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in acute kidney injury (AKI) through actions on the proximal tubule, but t
Publikováno v:
Semin Nephrol
Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI or prevent its progression to CKD. Wnt/β-catenin is a critical re
Autor:
Michael A. Raddatz, Brian R. Lindman, Meena S. Madhur, Jeffrey C. Rathmell, Matthew Z. Madden, Merryman Wd, Sabrina E. Booton, Tessa Huffstater, Bradley I. Reinfeld, Matthew R. Bersi, Rathmell Wk
ObjectiveMacrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1+/- model of calcific aortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71880e72b5461b90859953b69a54feaf
Autor:
Anna, Herland, Ben M, Maoz, Debarun, Das, Mahadevabharath R, Somayaji, Rachelle, Prantil-Baun, Richard, Novak, Michael, Cronce, Tessa, Huffstater, Sauveur S F, Jeanty, Miles, Ingram, Angeliki, Chalkiadaki, David, Benson Chou, Susan, Marquez, Aaron, Delahanty, Sasan, Jalili-Firoozinezhad, Yuka, Milton, Alexandra, Sontheimer-Phelps, Ben, Swenor, Oren, Levy, Kevin K, Parker, Andrzej, Przekwas, Donald E, Ingber
Publikováno v:
Nature biomedical engineering. 4(4)
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog