Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tessa Dignum"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109675- (2021)
Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyelo
Externí odkaz:
https://doaj.org/article/aeadf5874656435cb00af40d81bd981a
Our previous studies demonstrated the capacity of a stroma layer consisting of AGM-derived myrAKT-transduced endothelial cells (AGM-EC) to support the in vitro conversion of hemogenic endothelium (HE) to hematopoietic stem cells (HSCs) that functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e042036528e4660923d4c527bd824d
https://doi.org/10.21203/rs.3.pex-1035/v1
https://doi.org/10.21203/rs.3.pex-1035/v1
Autor:
Sanjay Srivatsan, Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Dana Jackson, Brandon Hadland, Shahin Rafii, Cole Trapnell, Adam M Heck, Tessa Dignum, Olivia Waltner, Irwin D. Bernstein, Stacey Dozono
SUMMARYDuring embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a84988cc0099f0305022ac79db16f9f
https://doi.org/10.1101/2021.04.13.439736
https://doi.org/10.1101/2021.04.13.439736
Autor:
Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Itkin T, Irwin D. Bernstein, Shahin Rafii, Jason M. Butler, Brandon Hadland, Cole Trapnell, Stacey Dozono, Tessa Dignum, Dana Jackson
Haematopoietic stem cells (HSCs) develop from haemogenic endothelium (HE) within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify the signals responsible for HSC formation, we used single cell RNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0aaf5cbe8278d008a5b99cc6cc4a89
https://doi.org/10.1101/2021.01.25.427999
https://doi.org/10.1101/2021.01.25.427999
Autor:
Shahin Rafii, Stacey Dozono, Brandon Hadland, Cole Trapnell, Barbara Varnum-Finney, Irwin D. Bernstein, Adam M Heck, Olivia Waltner, Dana Jackson, Sanjay Srivastan, Cynthia Nourigat-Mckay, Tessa Dignum
Publikováno v:
SSRN Electronic Journal.
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid progeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a983a6cd501aefb1318701a1307a58
https://doi.org/10.2139/ssrn.3832990
https://doi.org/10.2139/ssrn.3832990
During murine embryonic development, the first hematopoietic stem cells (HSCs) emerge within the major arterial vasculature, including the aorta-gonad-mesonephros (AGM) region. Throughout their emergence and subsequent maturation, HSCs retain a close
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f271310d962287e6c1681bb00bd477b
https://doi.org/10.21203/rs.3.pex-986/v1
https://doi.org/10.21203/rs.3.pex-986/v1
Autor:
Brandon Hadland, Tessa Dignum, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-McKay, Adam Heck, Olivia Waltner, Sanjay Srivatsan, Dana Jackson, Shahin Rafii, Cole Trapnell, Irwin Bernstein
Publikováno v:
Experimental Hematology. 100:S34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e1b96e7a2814cbd366e3e2654db4afc
https://doi.org/10.1016/j.exphem.2021.12.378
https://doi.org/10.1016/j.exphem.2021.12.378
Autor:
Cynthia Nourigat-Mckay, Olivia Waltner, Cole Trapnell, Tessa Dignum, Adam M Heck, Irwin D. Bernstein, Brandon Hadland, Dana Jackson, Barbara Varnum-Finney, Shahin Rafii, Stacey Dozono, Sanjay Srivatsan
Publikováno v:
Blood. 136:7-8
During embryonic development, blood cells emerge from hemogenic endothelium (HE), producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic stem cells (HSCs), which have the unique ability to self-renew and generate al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8d404c6960087b368ef1b9cf51fd23
https://doi.org/10.1182/blood-2020-142607
https://doi.org/10.1182/blood-2020-142607
Autor:
Irwin D. Bernstein, Cynthia Nourigat-Mckay, Olivia Waltner, Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Sanjay Srivatsan, Tessa Dignum, Shahin Rafii, Cole Trapnell, Adam M Heck
Publikováno v:
Experimental Hematology. 88:S57-S58
During embryonic development, blood cells emerge from hemogenic endothelium (HE), producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic stem cells (HSC), which have the unique ability to self-renew and generate all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3782bad7da0027a9412b495906c427b0
https://doi.org/10.1016/j.exphem.2020.09.080
https://doi.org/10.1016/j.exphem.2020.09.080