Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tessa C. Fitch"'
Autor:
Nicholas H. Stillman, Johnson A. Joseph, Jemil Ahmed, Charles Zuwu Baysah, Ryan A. Dohoney, Tyler D. Ball, Alexandra G. Thomas, Tessa C. Fitch, Courtney M. Donnelly, Sunil Kumar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Abberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson’s disease; therefore, a potential therapeutic strategy is the
Externí odkaz:
https://doaj.org/article/33653df251db405bb66003cb7c1cf223
Autor:
Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and
Externí odkaz:
https://doaj.org/article/90b6ab61face4e2e9229b5bec4e05f95
Autor:
Daisy Y. Shu, Scott I. Frank, Tessa C. Fitch, Margarete M. Karg, Erik R. Butcher, Emmanuella Nnuji-John, Leo A. Kim, Magali Saint-Geniez
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is a key feature of age-related macular degeneration (AMD), the leading cause of bl
Externí odkaz:
https://doaj.org/article/3648d0b4c0e048b698aee8e295c6130e
Autor:
Daisy Y. Shu, Leo A. Kim, Magali Saint-Geniez, Yutong Kelly Li, Scott I. Frank, Tessa C. Fitch
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea24bc333f2b3ffb157d5635178e76b9
https://doi.org/10.3791/64572
https://doi.org/10.3791/64572
Autor:
Nicholas H. Stillman, Johnson A. Joseph, Jemil Ahmed, Ryan A. Dohoney, Tyler D. Ball, Alexandra G. Thomas, Tessa C. Fitch, Courtney M. Donnelly, Sunil Kumar
We have developed a Oligopyridylamide (OP) based 2-Dimensional Fragment-Assisted Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) aggregation, a process central to Parkinson’s disease (PD). The 2D-FAST utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330ba3d8c4f2e12674c5abad50a4cd46
https://doi.org/10.1101/2022.07.11.499659
https://doi.org/10.1101/2022.07.11.499659
