Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tess Ely"'
Autor:
Yi Liu, Pingda Ren, Anjali Babbar, Sarah J. Firdaus, Jeffrey H. Chen, Tess Ely, Jun Feng, Jeff M. Kucharski, Yuching Chen, Linda V. Kessler, Ulf Peters, Rasmus Hansen, Lian-Sheng Li, Matthew R. Janes, Matthew P. Patricelli
Supplementary Table 1. Biochemical and Cell engagement SAR. Supplementary Table 2. Data collection and refinement statistics (Molecular replacement). Supplementary Table 3. Selectivity of ARS-853 across KRAS isoforms and GTP vs. GDP states. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4c1da5f413c618429e4a216ba9b29
https://doi.org/10.1158/2159-8290.22531619
https://doi.org/10.1158/2159-8290.22531619
Autor:
Jingchuan Zhang, Patrick P. Zarrinkar, Ulf Peters, Levan Darjania, Shisheng Li, Rasmus Hansen, Ke Yu, Ata Zarieh, Shuangwei Li, Dana D. Hu-Lowe, Jolanta Grembecka, Pingda Ren, Linda Kessler, Szymon Klossowski, Duxin Sun, Francis Burrows, Yvonne Yao, Tess Ely, Lian-Sheng Li, Yi Liu, Yuan Liu, Katarzyna Kempińska, Hongzhi Miao, Jeff Kucharski, Tao Wu, Trupta Purohit, Bo Wen, Tomasz Cierpicki, Jun Feng, Brian M. Linhares, Yi Wang
Publikováno v:
Cancer Research. 77:5077-5077
Patients with MLL-rearranged leukemia typically have a poor prognosis. With chemotherapy and stem cell transplantation as current standard of care, the 5-year survival rate is estimated to be only about 35%. As the leukemogenic activity of MLL fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0525c5c07caffe7b996830ab6d51de61
https://doi.org/10.1158/1538-7445.am2017-5077
https://doi.org/10.1158/1538-7445.am2017-5077
Autor:
Jeff Kucharski, Ulf Peters, Yun O. Long, Shisheng Li, Pingda Ren, Ata Zarieh, Dana D. Hu-Lowe, Ke Yu, Yuan Liu, Tao Wu, Carol Thach, Dirk Brehmer, Tess Ely, Xin Guo, Patrick P. Zarrinkar, Matthew P. Patricelli, Yi Wang, Rasmus Hansen, Dashyant Dhanak, Yi Liu, Jun Feng, Shuangwei Li, Matthew R. Janes, Yuching Chen, Sarah J. Firdaus, Levan Darjania, Linda Kessler, Jeffrey H. Chen, Xiaohu Deng, Yvonne Yao, Anjali Babbar, Matthew V. Lorenzi, Jingchuan Zhang, Lian-Sheng Li
Publikováno v:
Cell. 172:578-589.e17
KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd2f7a70c8f8bca445016883561281f
https://doi.org/10.1016/j.cell.2018.01.006
https://doi.org/10.1016/j.cell.2018.01.006