Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain

Autor: Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Flore Wouters, Koen Kuipers, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G. S. Verberk, Mansour Haidar, Jerome J. A. Hendriks, Jeroen F. J. Bogie

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)

Abstract Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benig

Externí odkaz: https://doaj.org/article/a6e816db044d4b4cb16b68a2c6586fad

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Autor: Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, Kévin Hardonnière, Tess Dierckx, Jana Van Broeckhoven, Celine Erens, Sven Hendrix, Saadia Kerdine-Römer, Jerome J. A. Hendriks, Jeroen F. J. Bogie

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)

Abstract Background The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS). Despite the importance of myelin internalization i

Externí odkaz: https://doaj.org/article/48a6620689ed48feb27566498ac8333d

Extracellular vesicle-associated cholesterol dictates the regenerative functions of macrophages in the brain

Autor: Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G.S. Verberk, Mansour Haidar, Jerome J.A. Hendriks, Jeroen F.J. Bogie

Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b120ea3d280c88a5f9ab4c9c9f6f88
https://doi.org/10.1101/2022.12.23.521775

The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Autor: Sam Vanherle, Winde Jorissen, Tess Dierckx, Melanie Loix, Elien Grajchen, Fleur Mingneau, Jeroen Guns, Pascal Gervois, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Monique T. Mulder, Alan T. Remaley, Mansour Haidar, Jerome J.A. Hendriks, Jeroen J.F. Bogie

Publikováno v: Cell Reports, 41(6):111591. Cell Press

The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987079cca7a30d80a99841aa1e71327
https://doi.org/10.1016/j.celrep.2022.111591

Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis

Autor: Jerome J. A. Hendriks, Elien Wouters, Elien Grajchen, Winde Jorissen, Mansour Haidar, Bart Staels, Tess Dierckx, Marie Paule Tulleners, Jeroen F. J. Bogie, Melanie Loix, Suzan Wetzels, Piet Stinissen

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, 21(23):9329. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 9329, p 9329 (2020)

Macrophages play a crucial role during the pathogenesis of multiple sclerosis (MS), a neuroinflammatory autoimmune disorder of the central nervous system. Important regulators of the metabolic and inflammatory phenotype of macrophages are liver X rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aab20f683251fea2015a265dd47967c