Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator.

Autor: Schwinghamer K; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, Kansas 66047, United States., Line S; Department of Pharmacology and Therapeutics, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada., Tesar DB; Department of Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Miller DW; Department of Pharmacology and Therapeutics, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada., Sreedhara A; Department of Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Siahaan TJ; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, Kansas 66047, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Apr 01; Vol. 21 (4), pp. 1639-1652. Date of Electronic Publication: 2024 Feb 23.

Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.

Autor: Kelley RF; Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Tesar DB; Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Wang Y; Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Agard NJ; Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Holder PG; Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Chan J; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Comps-Agrar L; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Horvath J; Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Horvath JD; Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Crowell SR; Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2022 May 02; Vol. 19 (5), pp. 1540-1547. Date of Electronic Publication: 2022 Apr 08.

A bioengineered anti-VEGF protein with high affinity and high concentration for intravitreal treatment of wet age-related macular degeneration.

Autor: Chengnan Huang¹, Yuelin Wang^2,3, Jinliang Huang⁴, Huiqin Liu⁴, Zhidong Chen¹, Yang Jiang^2,3 jiangyangpumch@126.com, Youxin Chen^2,3 chenyx@pumch.cn, Feng Qian¹ qianfeng@tsinghua.edu.cn

Publikováno v: Bioengineering & Translational Medicine. Mar2024, Vol. 9 Issue 2, p1-11. 11p.

Comparative pharmacokinetics of porcine and human anti-influenza hemagglutinin monoclonal antibodies in outbred pigs and minipigs.

Autor: Paudyal, Basudev, Moorhouse, Elliot, Sharma, Bhawna, Dodds, Michael, Nguyen, Victor, Milad, Mark, Tchilian, Elma

Publikováno v: Frontiers in Immunology; 2024, p1-8, 8p

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

Autor: Yip V; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Palma E; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Tesar DB; Drug Delivery Department; Pharma Technical Development, Genentech; South San Francisco, CA USA., Mundo EE; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Bumbaca D; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Torres EK; Non-Clinical Operations; Genentech Research & Early Development; South San Francisco, CA USA., Reyes NA; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Shen BQ; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Fielder PJ; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Prabhu S; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Khawli LA; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA., Boswell CA; Preclinical and Translational Pharmacokinetics; Genentech Research & Early Development; South San Francisco, CA USA.

Publikováno v: MAbs [MAbs] 2014 May-Jun; Vol. 6 (3), pp. 689-96. Date of Electronic Publication: 2014 Feb 26.