Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Tesaglitazar"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundSepsis is a heterogeneous disease, therefore the single-gene-based biomarker is not sufficient to fully understand the disease. Higher-level biomarkers need to be explored to identify important pathways related to sepsis and evaluate their
Externí odkaz:
https://doaj.org/article/b64b0709e3c34947aae124dea5e4c33e
Autor:
Julia Hartman, Gavin O'Mahony, Aditi Upadhye, Siva Sai Krishna Dasa, Tobias Kroon, Alexander L. Klibanov, Kimberly A. Kelly, Dustin K. Bauknight, Anh T. Nguyen, Jeremie Boucher, Victoria Osinski, Andrea Zhou, Coleen A. McNamara, James C. Garmey, Matthew J. Harms, Melissa A. Marshall, Prasad Srikakulapu
Publikováno v:
Theranostics
Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dual agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfa38fd32c10499280d1f19f515ac24
https://doi.org/10.7150/thno.36572
https://doi.org/10.7150/thno.36572
Autor:
Nora Klöting, Stefanie Wittrisch, Annette G. Beck-Sickinger, Matthias Blüher, Karin Mörl, Rima Chakaroun
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 31, Iss, Pp 163-180 (2020)
Mol. Metab. 31, 163-180 (2020)
Molecular Metabolism, Vol 31, Iss, Pp 163-180 (2020)
Mol. Metab. 31, 163-180 (2020)
Objective PPARα/γ dual agonists have been in clinical development for the treatment of metabolic diseases including type 2 diabetes and dyslipidemia. However, severe adverse side effects led to complications in clinical trials. As most of the benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a5984d3babe4cd79f900f950e2c37
https://doi.org/10.1016/j.molmet.2019.11.009
https://doi.org/10.1016/j.molmet.2019.11.009
Autor:
Rishi Sharma, Rangaramanujam M. Kannan, Louis DeRidder, Anjali Sharma, Kevin Liaw, John John, Sujatha Kannan
Publikováno v:
Nanoscale. 13:939-952
Switching microglia from a disease exacerbating, 'pro-inflammatory' state into a neuroprotective, 'anti-inflammatory' phenotype is a promising strategy for addressing multiple neurodegenerative diseases. Pro-inflammatory microglia contribute to disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ac77f4fff0966a56544067e866c78d
https://doi.org/10.1039/d0nr05958g
https://doi.org/10.1039/d0nr05958g
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Angela R. Ozburn, John C. Crabbe, Yuri A. Blednov, Pamela Metten, Sheena Potretzke, Kayla G. Townsley
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Rodent models of high alcohol drinking offer opportunities to better understand factors for Alcohol Use Disorders (AUD) and test potential treatments. Selective breeding was carried out to create two unique High Drinking in the Dark (HDID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb85e3b0cd71002955d20edbcf66e4b
https://doi.org/10.1111/acer.14269
https://doi.org/10.1111/acer.14269
Autor:
Nathalie Hennuyer, Diego Perez-Tilve, Felix Klingelhuber, Brian Finan, Cristina García-Cáceres, Daniel J. Drucker, Susanna M. Hofmann, Perla Cota, Fanny Lalloyer, Carmelo Quarta, Natalie Krahmer, Mostafa Bakhti, Stephan Herzig, Gustav Collden, Qian Zhang, Gandhari Maity, Gerald Grandl, Miguel A. Sánchez-Garrido, Richard D. Dimarchi, Bard Staels, Timo D. Müller, Aimée Bastidas-Ponce, Eric Baugé, Matthias Tschoep, Heiko Lickert, Konxhe Kulaj, Alexandra Harger, Kerstin Stemmer, Christoffer Clemmensen, Bin Yang, Aaron Novikoff
Dual-agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPAR𝛼/𝛾) have shown beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to unf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbe6c86c35688a6dbf16211c6cfbeea
https://doi.org/10.21203/rs.3.rs-1081959/v1
https://doi.org/10.21203/rs.3.rs-1081959/v1
Publikováno v:
Current Molecular Pharmacology
Background: Diabetes mellitus and concomitant dyslipidemia, being referred to as ‘diabetic dyslipidemia’, are the foremost detrimental factors documented to play a pivotal role in cardiovascular illness. Diabetic dyslipidemia is associated with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde870be3ea36dd7b423aef8f8f2deda
https://doi.org/10.2174/1874467212666190111165015
https://doi.org/10.2174/1874467212666190111165015
Autor:
Belal Azab, Sara A. Aldossary, Mansour Haddad, Mohammad Alsalem, Heba Kalbouneh, Aala Dweik, Khalid El-Salem, Amer Imraish
Publikováno v:
PPAR Research. 2019:1-9
Neuropathic pain is a growing healthcare problem causing a global burden. Currently used analgesics such as opioids are associated with adverse effects; urging the need for safer alternatives. Here we aimed to investigate the potential analgesic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a06df2b924442fa44dc1907d966d6c5
https://doi.org/10.1155/2019/2630232
https://doi.org/10.1155/2019/2630232
Publikováno v:
J Cardiovasc Pharmacol
The most common complications in patients with type-2 diabetes are hyperglycemia and hyperlipidemia that can lead to cardiovascular disease. Alleviation of these complications constitutes the major therapeutic approach for the treatment of diabetes m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f875fce9e8571bec724dfeb91e0b85
https://pubmed.ncbi.nlm.nih.gov/33165133
https://pubmed.ncbi.nlm.nih.gov/33165133