Výsledky vyhledávání - "Terwilliger, TC"

Can i solve my structure by SAD phasing? Anomalous signal in SAD phasing

Autor: Terwilliger, TC, Bunkóczi, G, Hung, LW, Zwart, PH, Smith, JL, Akey, DL, Adams, PD

Publikováno v: Terwilliger, TC; Bunkóczi, G; Hung, LW; Zwart, PH; Smith, JL; Akey, DL; et al.(2016). Can i solve my structure by SAD phasing? Anomalous signal in SAD phasing. Acta Crystallographica Section D: Structural Biology, 72(3), 346-358. doi: 10.1107/S2059798315019269. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4xh8x95g

© Terwilliger et al. 2016. A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. A simple theoretical framework for describing measurements of anomalous differences and the resulting useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::83170aeaff02581588ba64e6a1d89a92
http://www.escholarship.org/uc/item/4xh8x95g

Zobrazit plný text záznamu

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles

Autor: Van Benschoten, AH, Afonine, PV, Terwilliger, TC, Wall, ME, Jackson, CJ, Sauter, NK, Adams, PD, Urzhumtsev, A, Fraser, JS

Publikováno v: Acta crystallographica. Section D, Biological crystallography, vol 71, iss Pt 8
Van Benschoten, AH; Afonine, PV; Terwilliger, TC; Wall, ME; Jackson, CJ; Sauter, NK; et al.(2015). Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles. Acta Crystallographica Section D: Biological Crystallography, 71, 1657-1667. doi: 10.1107/S1399004715007415. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8q88m9nn

© 2015 International Union of Crystallography. Identifying the intramolecular motions of proteins and nucleic acids is a major challenge in macromolecular X-ray crystallography. Because Bragg diffraction describes the average positional distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b9f04cb5d29931c9c37248d1e2cf6bec
https://escholarship.org/uc/item/8q88m9nn

Zobrazit plný text záznamu

FEM: Feature-enhanced map

Autor: Afonine, PV, Moriarty, NW, Mustyakimov, M, Sobolev, OV, Terwilliger, TC, Turk, D, Urzhumtsev, A, Adams, PD

Publikováno v: Afonine, PV; Moriarty, NW; Mustyakimov, M; Sobolev, OV; Terwilliger, TC; Turk, D; et al.(2015). FEM: Feature-enhanced map. Acta Crystallographica Section D: Biological Crystallography, 71, 646-666. doi: 10.1107/S1399004714028132. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/97d776c9

© Afonine et al. 2015. A method is presented that modifies a 2mFobs- D FmodelσA-weighted map such that the resulting map can strengthen a weak signal, if present, and can reduce model bias and noise. The method consists of first randomizing the sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5cbef29545e41a8654b8c749f08afeb0
http://www.escholarship.org/uc/item/97d776c9

Zobrazit plný text záznamu

Ligand placement based on prior structures: the guided ligand-replacement method

Autor: Klei, HE, Moriarty, NW, Echols, N, Terwilliger, TC, Baldwin, ET, Pokross, M, Posy, S, Adams, PD

Publikováno v: Acta crystallographica. Section D, Biological crystallography, vol 70, iss Pt 1
Klei, HE; Moriarty, NW; Echols, N; Terwilliger, TC; Baldwin, ET; Pokross, M; et al.(2014). Ligand placement based on prior structures: the guided ligand-replacement method. Acta Crystallographica Section D: Biological Crystallography, 70(1), 134-143. doi: 10.1107/S1399004713030071. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5k97w236

The process of iterative structure-based drug design involves the X-ray crystal structure determination of upwards of 100 ligands with the same general scaffold (i.e. chemotype) complexed with very similar, if not identical, protein targets. In conju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::018439424795decad6efb37e0a8cef24
https://escholarship.org/uc/item/5k97w236

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání