Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.

Autor: Kosuke Okuda, Keizo Takao, Aya Watanabe, Tsuyoshi Miyakawa, Masashi Mizuguchi, Teruyuki Tanaka

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196587 (2018)

Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on the C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-

Externí odkaz: https://doaj.org/article/c27cf464230f413db806a3cf6a667d7f

Microtubule dynamics in neuronal morphogenesis

Autor: Akira Sakakibara, Ryota Ando, Tamar Sapir, Teruyuki Tanaka

Publikováno v: Open Biology, Vol 3, Iss 7 (2013)

Microtubules (MTs) are essential for neuronal morphogenesis in the developing brain. The MT cytoskeleton provides physical support to shape the fine structure of neuronal processes. MT-based motors play important roles in nucleokinesis, process forma

Externí odkaz: https://doaj.org/article/88a536d759b240f0b94ba13ba1f6a12e

Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration

Autor: Thomas Braun, Piera De Gaspari, Shin'ichi Takeda, Teruyuki Tanaka, Naohiro Hashimoto, Yuran Ma, Hiroshi Yamamoto, Satoshi Murakami, Kazutake Tsujikawa, Akiyoshi Uezumi, Shizuka Uchida, Takuji Ohtani, Takahito Ito, Ryo Ogawa, So-ichiro Fukada, Yuko Miyagoe-Suzuki, Masahiko Yamaguchi, Yoko Watanabe, Miki Nakamura

Publikováno v: Development. 142:51-61

Muscle satellite cells are indispensable for muscle regeneration, but the functional diversity of their daughter cells is unknown. Here, we show that many Pax7+MyoD− cells locate both beneath and outside the basal lamina during myofiber maturation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6544c52d12bb22eeef6fcf84cc350ef6
https://doi.org/10.1242/dev.112557

Expression of c-Fos protein in the brain after intravenous injection of ghrelin in rats

Autor: Koji Yakabi, Yukimi Johno, Kiyoshige Takayama, Teruyuki Tanaka, Shoki Ro, Kaori Hayashi

Publikováno v: Neuroscience Letters. 417:292-296

In this study, we surveyed central neurons that might be activated after peripheral administration of a gut-brain peptide ghrelin, by examining neurons expressing c-Fos protein. First, we examined the relationship between the dose of ghrelin and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94006b3948546d2660b036858330da7
https://doi.org/10.1016/j.neulet.2007.02.089