Výsledky vyhledávání - "Terutaka Hashizume"

Dicationic dithiocarbamate carbapenems with anti-MRSA activity

Autor: Hiroki Sato, Hideo Kiyonaga, Minoru Moriya, Yuichi Sugimoto, Shinnosuke Abe, Chinatsu Ikeura, Aya Shimizu, Terutaka Hashizume, Hideki Jona, Rie Nagano, Hideaki Imamura, Hajime Morishima, Norikazu Ohtake, Koji Yamada, Masato Nakano

Publikováno v: Bioorganic & Medicinal Chemistry. 9:1571-1578

A new class of 1 beta-methylcarbapenems bearing a doubly quaternarized 1,4-diazabicyclooctane (DABCO) substituted dithiocarbamate moiety at the C-2 side chain was prepared, and the biological profiles of the compounds, including in vitro and in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c872a2be3182e91c4bc9d9c021e0608
https://doi.org/10.1016/s0968-0896(01)00044-x

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In Vitro Activities of Novel trans -3,5-Disubstituted Pyrrolidinylthio-1β-Methylcarbapenems with Potent Activities against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

Autor: Rie Nagano, Kaneyoshi Shibata, Hideaki Imamura, Hajime Morishima, Yuka Adachi, Terutaka Hashizume

Publikováno v: Antimicrobial Agents and Chemotherapy. 44:489-495

The in vitro activities of the novel 1β-methylcarbapenems J-111,225, J-114,870, and J-114,871, which have a structurally unique side chain that consists of a trans -3,5-disubstituted 5-arylpyrrolidin-3-ylthio moiety at the C-2 position, were compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0b235b259f2fa80610b73feb6f2def6
https://doi.org/10.1128/aac.44.3.489-495.2000

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Structure–activity relationships of trans -3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems. Part 1: J-111,347 and related compounds

Autor: Koji Yamada, Aya Shimizu, Norikazu Ohtake, Hideaki Imamura, Hajime Morishima, Terutaka Hashizume, Ryosuke Ushijima, Rie Nagano, Hideki Jona, Hiroki Sato

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:109-113

1Beta-methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio-side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a277ff2888880865174a76457ed9b4d
https://doi.org/10.1016/s0960-894x(99)00657-5

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Carbapenem Derivatives as Potential Inhibitors of Various β-Lactamases, Including Class B Metallo-β-Lactamases

Autor: Koji Yamada, Terutaka Hashizume, Rie Nagano, Yuka Adachi, Hideaki Imamura, Hajime Morishima

Publikováno v: Antimicrobial Agents and Chemotherapy. 43:2497-2503

A variety of 1β-methylcarbapenem derivatives were screened to identify inhibitors of IMP-1 metallo-β-lactamase, a class B β-lactamase, in an automated microassay system using nitrocefin as a substrate. The structure–inhibitory-activity relations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbceb9900d3ff59fdf99c193b59d6bd
https://doi.org/10.1128/aac.43.10.2497

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Therapeutic efficacy of BO-3482, a novel dithiocarbamate carbapenem, in mice infected with methicillin-resistant Staphylococcus aureus

Autor: Tomoyo Naito, Kaneyoshi Shibata, Terutaka Hashizume, Kayo Asano, Aisaku Fuse, Nakagawa Susumu, Rie Nagano

Publikováno v: Antimicrobial Agents and Chemotherapy. 41:2278-2281

The in vivo activity of BO-3482, which has a dithiocarbamate chain at the C-2 position of 1beta-methyl-carbapenem, was compared with those of vancomycin and imipenem in murine models of septicemia and thigh infection with methicillin-resistant Staphy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a19ede7c822f0a6f11927ad4c17308
https://doi.org/10.1128/aac.41.10.2278

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In vitro evaluation of BO-3482, a novel dithiocarbamate carbapenem with activity against methicillin-resistant staphylococci

Autor: Nakagawa Susumu, Terutaka Hashizume, N Hazumi, K Nakamura, Y Adachi, Y Kato

Publikováno v: Antimicrobial Agents and Chemotherapy. 41:2282-2285

BO-3482, a dithiocarbamate carbapenem, inhibited clinical isolates of methicillin-resistant staphylococci (MRS) at 6.25 microg/ml (MIC at which 90% of isolates tested are inhibited [MIC90]), while the MIC90 of imipenem was > 100 microg/ml. BO-3482 wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319757def34e1dc08b5225f6d9d4ed12
https://doi.org/10.1128/aac.41.10.2282

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ChemInform Abstract: Structure-Activity Relationships of trans-3,5-Disubstituted Pyrrolidinylthio-1β-methylcarbapenems. Part 1. J-111,347 and Related Compounds

Autor: Hajime Morishima, Hideaki Imamura, Rie Nagano, Hideki Jona, Koji Yamada, Aya Shimizu, Terutaka Hashizume, Norikazu Ohtake, Hiroki Sato, Ryosuke Ushijima

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b453f743c047283465c5909108856be
https://doi.org/10.1002/chin.200020203

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Synthesis and Antifungal Activity of Novel 14-Membered Benzomacrolides as Galbonolide Analogues

Autor: Koji Yamada, Yuichi Sugimoto, Hideki Jona, Rie Bamba-Nagano, Hajime Morishima, Shunji Sakuraba, Terutaka Hashizume, Hiroki Sakoh, Hideaki Imamura

Publikováno v: ChemInform. 35

Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6a9270f331011430e1a279a440beee
https://doi.org/10.1002/chin.200430207

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