Výsledky vyhledávání - "Terushi Haradahira"

Synthesis and characterization of 11 C-labeled benzyl amidine derivatives as PET radioligands for GluN2B subunit of the NMDA receptors

Autor: Takashi Okauchi, Takahiro Mukai, Noriko Fujimoto, Jun Maeda, Yumiko Nojiri, Terushi Haradahira, Tetsuya Suhara, Minoru Maeda, Takeshi Fuchigami, Morio Nakayama, Fumihiko Yamamoto

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 61:1095-1105

GluN2B-containing NMDA receptors (NMDARs) play fundamental roles in learning and memory, although they are also associated with various brain disorders. In this study, we synthesized and evaluated three 11 C-labeled N-benzyl amidine derivatives 2-[11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5f5ede38a10b541ff5676c6a7e36e2c
https://doi.org/10.1002/jlcr.3691

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Synthesis and characterization of

Autor: Takeshi, Fuchigami, Noriko, Fujimoto, Terushi, Haradahira, Yumiko, Nojiri, Takashi, Okauchi, Jun, Maeda, Tetsuya, Suhara, Fumihiko, Yamamoto, Morio, Nakayama, Minoru, Maeda, Takahiro, Mukai

Publikováno v: Journal of labelled compoundsradiopharmaceuticals. 61(14)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b8a17be5460659863a9dcb9cd8dacb3
https://pubmed.ncbi.nlm.nih.gov/30375667

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Synthesis and characterization of [125I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1

Autor: Morio Nakayama, Takeshi Fuchigami, Mamoru Haratake, Yasuhiro Magata, Terushi Haradahira

Publikováno v: Bioorganic & Medicinal Chemistry. 19:6245-6253

In this study, 2-iodo substituted 1-methylpiperidin-2-yl benzamide derivatives were synthesized and evaluated as candidate SPECT imaging agents for glycine transporter 1 (GlyT1). In JAR cells, which predominantly express GlyT1, 2-iodo N-[(S)-{(S)-1-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7d2ead479c4c2904cbe81efff2f23e
https://doi.org/10.1016/j.bmc.2011.09.010

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Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors

Autor: Jun Maeda, Takahiro Mukai, Yumiko Nojiri, Yasuhiro Magata, Kazutoshi Suzuki, Hiroshi Yamaguchi, Noriko Fujimoto, Tetsuya Suhara, Fumihiko Yamamoto, Takeshi Fuchigami, Minoru Maeda, Terushi Haradahira, Takashi Okauchi, Mikako Ogawa

Publikováno v: Bioorganic & Medicinal Chemistry. 17:5665-5675

In this study, we synthesized and evaluated several amino 4-hydroxy-2(1H)-quinolone (4HQ) derivatives as new PET radioligand candidates for the glycine site of the NMDA receptors. Among these ligands, we discovered that 7-chloro-4-hydroxy-3-{3-(4-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0271a5a2c9918aa5c45b330d183f24
https://doi.org/10.1016/j.bmc.2009.06.014

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Synthesis of 11C-Labelled Bis(phenylalkyl)amines and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains

Autor: Minoru Maeda, Fumie Kurosaki, Kazutoshi Suzuki, Furnihiko Yamamoto, Jun Maeda, Terushi Haradahira, Takashi Okauchi, Tetsuya Suhara, Shigeki Sasaki

Publikováno v: Biological and Pharmaceutical Bulletin. 27:531-537

Two new (11)C-labelled ligands, N-(3-(4-hydroxyphenyl)propyl)-3-(4-methoxyphenyl)propylamine ([(11)C]2) and N-(3-(4-hydroxyphenyl)butyl)-3-(4-methoxyphenyl)butylamine ([(11)C]3) were designed based on bis(phenylalkyl)amines (1) which have been report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3849002e17b788797149f1166ad56bc
https://doi.org/10.1248/bpb.27.531

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Synthesis and Brain Regional Distribution of [11C]NPS 1506 in Mice and Rat: an N-Methyl-D-aspartate (NMDA) Receptor Antagonist

Autor: Minoru Maeda, Kazutoshi Suzuki, Takuya Arai, Takeshi Fuchigami, Fumihiko Yamamoto, Terushi Haradahira, Tetsuya Suhara, Takashi Okauchi, Shigeki Sasaki, Jun Maeda

Publikováno v: Biological and Pharmaceutical Bulletin. 26:1570-1573

NPS 1506 [3-fluoro-gamma-(3-fluorophenyl)-N-methylbenzenepropamine] is representative of a non-psychotomimetic class of N-methyl-D-aspartate (NMDA) receptor antagonists. [11C]NPS 1506 was prepared at high radiochemical purity (>98%) with a specific a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fb5e404f672fac183245094bb719b4
https://doi.org/10.1248/bpb.26.1570

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Synthesis,in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606,(+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol,as a PET tracer for NR2B subunit-containing NMDA receptors

Autor: Minoru Maeda, Kazutoshi Suzuki, Takayo Kida, Junko Hojo, Takuya Arai, Jun Maeda, Fumihiko Yamamoto, Takashi Okauchi, Terushi Haradahira, Tetsuya Suhara, Shigeki Sasaki, Ming-Rong Zhang

Publikováno v: Nuclear Medicine and Biology. 29:517-525

A carbon-11 labeled methoxyl analog of CP-101,606, (±) threo- 1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[ 11 C]methoxyphenyl)piperidino]-1-propanol [(±)[ 11 C]1], was synthesized as a new subtype-selective PET radioligand for NMDA receptors. The in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a2e2741b598c0ed92bcecd57e2c1f
https://repo.qst.go.jp/records/44313

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Synthesis and preliminary PET study of the 5-HT7 receptor antagonist [11C]DR4446

Autor: Jun Maeda, Kazutoshi Suzuki, Tetsuya Suhara, Terushi Haradahira, Takayo Kida, Ming-Rong Zhang, Takashi Okauchi, Shigeru Obayashi

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 45:857-866

DR4446 (1-methyl-2a-[4-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)butyl]-2a,3,4,5-tetrahydro-1H-benz[cd]indole-2-one) is a potent 5-HT7 receptor antagonist (Ki=9.7 nM) with a high selectivity over other 5-HT family receptors (Ki for 5-HT1A: 770 nM;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9818571b7991f58fbf09378eb1666a5b
https://doi.org/10.1002/jlcr.606

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Synthesis and evaluation of18F- and11C-labelled 9,10-ethanobenzo[b]quinolizinium derivatives for imaging of the NMDA receptor at the TCP-binding site

Autor: Terushi Haradahira, Minoru Maeda, Kazutoshi Suzuki, Tetsuya Suhara, Shigeki Sasaki, Nobuyasu Ishibashi, Fumihiko Yamamoto, Tsuneo Kuwamura, Hiromi Sano

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 43:375-383

Derivatives of 9,10-ethanobenzo[b]quinolizinium are potent antagonists for the TCP-site of the NMDA receptor. Two fluoroethyl-substituted analogues were labelled with fluorine-18 by displacement of the tosylate with [18F]fluoride, followed by a Diels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7380fdc905812fffc6a46e32dbd9426
https://doi.org/10.1002/(sici)1099-1344(20000330)43:4<375::aid-jlcr324>3.0.co

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Automatic synthesis of l-[β-11C]amino acids using an immobilized enzyme column

Autor: Kazutoshi Suzuki, M. Sasaki, Terushi Haradahira, Yasuyoshi Watanabe, M Mutoh, Akira Tanaka, M. Ikemoto

Publikováno v: Applied Radiation and Isotopes. 52:199-204

We have developed a system for the automatic synthesis of L-[beta-11C]amino acids for i.v. injection by means of enzyme-mediated reactions from 11CO2 via 11CH3I and D,L-[beta-11C]alanine as labeled intermediates. This system, which incorporates an ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e35d6025403ab4e1029ed655c4a7c0
https://doi.org/10.1016/s0969-8043(99)00118-9

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