Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Teruo Utsumi"'
Autor:
Yilin Yang, Jain Jeong, Tingting Su, Sanchuan Lai, Pengpeng Zhang, Rolando Garcia-Milian, Morven Graham, Xinran Liu, Matthew J. McConnell, Teruo Utsumi, Joao Pereira, Yasuko Iwakiri
Publikováno v:
JHEP Reports, Vol 6, Iss 7, Pp 101069- (2024)
Background & Aims: The lymphatic system plays crucial roles in maintaining fluid balance and immune regulation. Studying the liver lymphatics has been considered challenging, as common lymphatic endothelial cell (LyEC) markers are expressed by other
Externí odkaz:
https://doaj.org/article/119e1438805e41c6a0be5f32711b6447
Autor:
Tingting Su, Yilin Yang, Sanchuan Lai, Jain Jeong, Yirang Jung, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1139-1161 (2021)
Background: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous liv
Externí odkaz:
https://doaj.org/article/235662cb3e174f19bd4275098a6286c6
Autor:
Jain Jeong, Masatake Tanaka, Yilin Yang, Arefyev, Nikolai, DiRito, Jenna, Tietjen, Gregory, Xuchen Zhang, McConnell, Matthew J., Teruo Utsumi, Yasuko Iwakiri
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Nov2023, Vol. 325 Issue 5, pG379-G390, 12p
Autor:
Carlos Fernández-Hernando, Aurelio Sonzogni, Yasuko Iwakiri, Zhaoli Sun, Alfred Ian Lee, Sandro Sironi, Matthew McConnell, Alexander B Pine, Pietro Andrea Bonaffini, Hua Qing, Xuchen Zhang, Teruo Utsumi, Nao Kawaguchi, Christina Price, Maria Alessio, Lisa Licini, Giulia Previtali, John Hwa, Mario Strazzabosco, Clarissa Valle, Reiichiro Kondo, Michela Seghezzi, Andrew Wang, Xinbo Zhang, Hyung J. Chun
Publikováno v:
Journal of Hepatology
Background and Aims COVID-19 is associated with liver injury and elevated interleukin-6 (IL-6). We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aed7166d6e5a62f138ee5dd3213933a
https://doi.org/10.1016/j.jhep.2021.04.050
https://doi.org/10.1016/j.jhep.2021.04.050
Autor:
Matthew McConnell, Sandro Sironi, Yasuko Iwakiri, Zhaoli Sun, Pietro Andrea Bonaffini, Maria Alessio, Lisa Licini, Michela Seghezzi, Teruo Utsumi, Mario Strazzabosco, Giulia Previtali, Clarissa Valle, Reiichiro Kondo, Nao Kawaguchi, Aurelio Sonzogni, Xuchen Zhang
Publikováno v:
Hepatology Research
Aim Coronavirus disease (COVID‐19) is characterized by pneumonia with secondary damage to multiple organs including the liver. Liver injury (elevated alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) often correlates with disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29370d47d24d930a769fd0668a97e36a
https://doi.org/10.1111/hepr.13696
https://doi.org/10.1111/hepr.13696
Autor:
Asuka Inada, Alexandra S. Piotrowski-Daspit, Junwei Zhang, Gregory T. Tietjen, Jenna DiRito, Jordan S. Pober, Young-Eun Seo, Christine J. Wu, W. Mark Saltzman, Mingjie Shao, Jiajia Cui, Eric Song, Teruo Utsumi, Laura G. Bracaglia, Yasuko Iwakiri
Publikováno v:
J Control Release
Degradable poly(amine-co-ester) (PACE) terpolymers hold tremendous promise for siRNA delivery because these materials can be formulated into delivery vehicles with highly efficient siRNA encapsulation, providing effective knockdown with low toxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b10eb476fe99ff01f2d0ef9aba91950
https://doi.org/10.1016/j.jconrel.2019.04.044
https://doi.org/10.1016/j.jconrel.2019.04.044
Autor:
Reiichiro Kondo, Yirang Jung, Matthew McConnell, William C. Sessa, Teruo Utsumi, Panjamaporn Sangwung, Jain Jeong, Yilin Yang, Yasuko Iwakiri
Publikováno v:
J Hepatol
Background & Aims Liver sinusoidal endothelial cell (LSEC) dysfunction has been reported in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus, we investigated this, as well as the mechanisms of alcohol-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18c3a7719b856b0a83485484c181bff
https://pubmed.ncbi.nlm.nih.gov/33675874
https://pubmed.ncbi.nlm.nih.gov/33675874
Autor:
Yirang Jung, William C. Sessa, Teruo Utsumi, Reiichiro Kondo, Matthew McConnell, Panjamaporn Sungwung, Yilin Yang, Yasuko Iwakiri
BackgroundIt is unknown whether liver sinusoidal endothelial cells (LSECs) metabolize alcohol. Chronic alcohol consumption decreases endothelial nitric oxide synthase (eNOS)-derived NO production typical of LSEC dysfunction. Heat shock protein 90 (Hs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eb39c042e087071cb009cdd7e1a54f0
https://doi.org/10.1101/2020.08.25.267096
https://doi.org/10.1101/2020.08.25.267096
Autor:
Matthew McConnell, Jain Jeong, Shao-Jung Hsu, Chihao Zhang, Teruo Utsumi, Seong-il Lee, Yasuko Iwakiri
Publikováno v:
Gastroenterology
Background and aimsHepatic encephalopathy (HE) is a serious neurological complication in patients with liver cirrhosis. Nothing is known about the role of the meningeal lymphatic system in HE. We tested our hypothesis that enhancement of meningeal ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b37a4988dc9e58c8d39bc26a8f390ec
https://doi.org/10.1101/2020.05.01.072611
https://doi.org/10.1101/2020.05.01.072611
Autor:
Yilin Yang, Yasuko Iwakiri, Tingting Su, Sanchuan Lai, Yirang Jung, Matthew McConnell, Teruo Utsumi, Jain Jeong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1139-1161 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a0fd79880138cee7b6377dedf6c7ba
https://doi.org/10.1101/2020.03.18.997452
https://doi.org/10.1101/2020.03.18.997452