Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Teruo Sugawara"'
Autor:
Katsuhiko Warita, Takanori Miki, Yoshiki Matsumoto, Teruo Sugawara, Takashi Nanmori, Hideto Yamada, Yoshiaki Tabuchi, Tomoko Mitsuhashi, Yasuhiko Ebina, Jeffrey A. Kant, Noriaki Sakuragi, Ichiro Takasaki, Toshifumi Yokoyama, Takashi Kondo, Nobuhiko Hoshi, Hiroshi Kitagawa, Yoshiki Takeuchi, Fumio Hayashi, Zhi-Yu Wang
Publikováno v:
Congenital Anomalies. 50:40-51
XY females are rare individuals who carry a Y chromosome but are phenotypically female. In approximately 80-90% of these cases, there are no mutations in the SRY gene, a testis-determining gene on the short arm of the Y chromosome, and the pathophysi
Autor:
Yoshiaki Tabuchi, Noriaki Sakuragi, Tomoko Mitsuhashi, Yoshiki Takeuchi, Ichiro Takasaki, Nobuhiko Hoshi, Takanori Miki, Yoshiki Matsumoto, Jeffrey A. Kant, Fumio Hayashi, Hiroshi Kitagawa, Katsuhiko Warita, Takashi Nanmori, Zhi-Yu Wang, Teruo Sugawara, Toshifumi Yokoyama, Hideto Yamada, Yasuhiko Ebina, Takashi Kondo
Publikováno v:
Congenital Anomalies. 50:85-94
In normal ontogenetic development, the expression of the sex-determining region of the Y chromosome (SRY) gene, involved in the first step of male sex differentiation, is spatiotemporally regulated in an elaborate fashion. SRY is expressed in germ ce
Autor:
Shiho Fukui, Takashi Tanida, Nobuhiko Hoshi, Kana Ishihara, Katsuhiko Warita, Tomoko Mitsuhashi, Hiroshi Kitagawa, Tetsurou Inamoto, Takashi Nanmori, Toshifumi Yokoyama, Wang-Mei Qi, Yoshiaki Tabuchi, Teruo Sugawara
Publikováno v:
Toxicology Letters. 189:40-47
A major question is whether exposure to mixtures of low-dose endocrine disruptors (EDs) having different action mechanisms affects neurodevelopment differently than exposure to EDs individually. We therefore investigated the effects of fetal and neon
Autor:
Zhan-Peng Yue, Yoshiki Matsumoto, Yoshiki Takeuchi, Toshifumi Yokoyama, Hiroshi Kitagawa, Kazutaka Okamoto, Ken-ichiro Mutoh, Takanori Miki, Teruo Sugawara, Nobuhiko Hoshi, Yoshihisa Hasegawa, Katsuhiko Warita
Publikováno v:
Biology of Reproduction. 78:59-67
We aimed to elucidate the mechanism of action of estrogenic endocrine disruptors and the rescue of reproductive function, particularly the responsiveness of testes to eCG and/or activin A (ACT) after establishing reproductive disorders. Newborn male
Autor:
Takashi Tanida, Kana Ishihara, Teruo Sugawara, Hiroshi Kitagawa, Katsuhiko Warita, Nobuhiko Hoshi
Publikováno v:
Journal of Veterinary Medical Science. 69:347-352
In 1976, men who were exposed to the highest concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after an explosion at a chemical plant near Seveso, Italy, produced more girls than boys. However, few studies have examined the possibility tha
Autor:
Teruo Sugawara, E. Nomura
Publikováno v:
Toxicology Mechanisms and Methods. 16:287-294
Endocrine systems of humans and animals are disturbed by dioxin-like compounds, which are ligands of the aryl hydrocarbon receptor (AhR). It is important to determine the accumulation of dioxin-like compounds in the environment for maintenance of hum
Autor:
Teruo Sugawara, Seiichiro Fujimoto
Publikováno v:
Biochemical Journal. 380:153-160
The first step in the biosynthesis of steroid hormones is conversion of cholesterol into pregnenolone. StAR (steroidogenic acute regulatory) protein plays a crucial role in the intra-mitochondrial movement of cholesterol. STS (steroid sulphatase), wh
Publikováno v:
Journal of Endocrinology. 180:135-144
Endometrial carcinoma is a common malignancy of the genital tract. In the present study, we examined the expression of human steroidogenic acute regulatory (StAR) protein, P450 side-chain cleavage enzyme (P450 scc), 17alpha-hydroxylase/17,20-desmolas
Autor:
Syuji Abe, Yuko Fujimoto, Seiichiro Fujimoto, Kenji Fujieda, Eiji Nomura, Masaki Saito, Teruo Sugawara, Noriaki Sakuragi
Publikováno v:
Endocrinology. 142:3570-3577
Coregulators have been suggested to act as a bridging apparatus between nuclear receptors and the transcriptional machinery. The orphan receptor SF-1 plays a role in controlling the basal and cAMP-stimulated expression of the human steroidogenic acut
Publikováno v:
Hormone Research in Paediatrics. 56:182-187
Background: X-linked ichthyosis (XLI) is an inherited skin disorder caused by a deficiency of steroid sulfatase (STS). The gene and protein of STS were examined in 19 Japanese patients with XLI. Results: In Western blotting analysis, no cross-reactin