Výsledky vyhledávání - "Teruo Kutsuma"

Reductive Alkylation of Hydrazine Derivatives with α-Picoline-Borane and Its Applications to the Syntheses of Useful Compounds Related to Active Pharmaceutical Ingredients

Autor: Yasushi Kawase, Teruo Kutsuma, Jun-ya Kato, Takeo Iwakuma, Tadashi Kataoka, Takehiro Yamagishi, Tsutomu Yokomatsu

Publikováno v: Synthesis. 46:455-464

An efficient method for the direct reductive alkylation of hydrazine derivatives with α-picoline-borane has been developed to synthesize a variety of N-alkylhydrazine derivatives. This method provided N,N-dialkylhydrazine derivatives and N-monoalkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5358a824cb98685ec72eea61af20477a
https://doi.org/10.1055/s-0033-1340484

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A Safe and Scalable Procedure for Preparation of α-Picoline–Borane from Sodium Mono-acyloxyborohydrides and α-Picoline

Autor: Tomohiro Kimura, Tadashi Nakata, Teruo Kutsuma, Tsutomu Yokomatsu, Yoshinori Yamamoto, Tadashi Kataoka, Huo Zhibao, Yasushi Kawase, Takehiro Yamagishi

Publikováno v: Organic Process Research & Development. 16:495-498

Sodium monobenzoxyborohydride, which is easily prepared from sodium borohydride and benzoic acid in THF in situ, is treated with α-picoline in THF under mild conditions to give α-picoline–borane in an excellent yield. This method can be a practic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1b9d13b998525fb0b477d83b5fcb07
https://doi.org/10.1021/op2003858

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N-Benzyl-Protection of Amino Acid Derivatives by Reductive Alkylation with α-Picoline-Borane

Autor: Tadashi Kataoka, Tsutomu Yokomatsu, Kimio Ueda, Teruo Kutsuma, Takeo Iwakuma, Takehiro Yamagishi, Yasushi Kawase, Tadashi Nakata

Publikováno v: Synthesis. 2010:1673-1677

A convenient method for N-protection of amino acid derivatives with a benzyl group by reductive alkylation of amino acid derivatives with α-picoline-borane is described. Amino acid esters or amino alcohols were treated with aryl aldehydes in methano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a3d2a09d10bb4c43e2a6b4b1d0345c0
https://doi.org/10.1055/s-0029-1218707

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A Novel Histamine 2(H2) Receptor Antagonist with Gastroprotective Activity. I. Synthesis and Pharmacological Evaluation of N-Phenoxypropylacetamide Derivatives with Thioether Function

Autor: Tetsuaki Yamaura, Noriaki Kashiwaba, Yasuo Sekine, Matsumoto Hajime, Teruo Kutsuma, Hirakawa Nobuhiko, Akihiro Sekine

Publikováno v: Chemical and Pharmaceutical Bulletin. 46:610-615

In an attempt to develop new types of anti-ulcer agents, a series of N-(phenoxypropyl)acetamide derivatives with a thioether moiety and their sulfur-oxidized analogues were synthesized and evaluated for histamine H2-receptor antagonistic activity, Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4b38521bd6b70299abe634076bd7b0
https://doi.org/10.1248/cpb.46.610

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Pharmacokinetic behavior and pharmacological activity of diclofenac modified by phospholipid-like compound

Autor: Yukio Soeda, Kozo Takayama, Yasuko Obata, Junzo Kamei, Teruo Kutsuma, Tsuneji Nagai, Takae Hirakawa, Toshio Honda

Publikováno v: Drug Delivery System. 12:167-173

Prodrug of diclofenac (DF-C2-P) was synthesized by introducing phospholipid-like compound into carboxyl group in the mother molecule. DF-C2-P was rapidly decomposed in neutral and alkaline solution while stable in acidic medium. A considerable increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f74d94bd503be22b6e827de59965119
https://doi.org/10.2745/dds.12.167

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A Practical Synthesis of 8-Hydroxyacyclovir and 9-(Carboxymethoxymethyl)guanine, Metabolites of Acyclovir

Autor: Yasuo Sakai, Hiroyuki Ouchi, Takehiro Yamagishi, Tsutomu Yokomatsu, Shiroshi Shibuya, Noriaki Shiina, Teruo Kutsuma

Publikováno v: HETEROCYCLES. 65:1967

Improved methods for the synthesis of 8-hydroxyacyclovir and 9-(carboxymethoxymethyl)guanine, metabolites of acyclovir, were examined. The methods were found to be useful for practical preparation of 8-hydoxyacyclovir and9-(caboxymethoxymethyl)guanin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b92f75259a69737db268d798559c38c
https://doi.org/10.3987/com-05-10430

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