Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Terunao Takahara"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6520 (2024)
Cell death-inducing p53-target protein 1 (CDIP1) is a proapoptotic protein that is normally expressed at low levels and is upregulated by genotoxic and endoplasmic reticulum stresses. CDIP1 has been reported to be localized to endosomes and to intera
Externí odkaz:
https://doaj.org/article/289bfc4e483741ee99a1c0f0e91515fd
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3923 (2023)
Environmental factors are important regulators of cell growth and proliferation. Mechanistic target of rapamycin (mTOR) is a central kinase that maintains cellular homeostasis in response to a variety of extracellular and intracellular inputs. Dysreg
Externí odkaz:
https://doaj.org/article/58463d929d0a450e8c12c992f0351645
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-16 (2020)
Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically r
Externí odkaz:
https://doaj.org/article/3cd1d0a840ca40cbaef928ad37f3d333
Autor:
Yuna Amemiya, Nao Nakamura, Nao Ikeda, Risa Sugiyama, Chiaki Ishii, Masatoshi Maki, Hideki Shibata, Terunao Takahara
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6897 (2021)
Mechanistic target of rapamycin complex 1 (mTORC1) is a master growth regulator by controlling protein synthesis and autophagy in response to environmental cues. Amino acids, especially leucine and arginine, are known to be important activators of mT
Externí odkaz:
https://doaj.org/article/e21d571a140e4fdfaa4fa7a5ae4efc25
Autor:
Ryuta Inukai, Kanako Mori, Keiko Kuwata, Chihiro Suzuki, Masatoshi Maki, Terunao Takahara, Hideki Shibata
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1175 (2021)
Apoptosis-linked gene 2 (ALG-2, also known as PDCD6) is a member of the penta-EF-hand (PEF) family of Ca2+-binding proteins. The murine gene encoding ALG-2 was originally reported to be an essential gene for apoptosis. However, the role of ALG-2 in c
Externí odkaz:
https://doaj.org/article/f194606f89b64ae18156f1ca14a861e7
Autor:
Wei Zhang, Ayaka Muramatsu, Rina Matsuo, Naoki Teranishi, Yui Kahara, Terunao Takahara, Hideki Shibata, Masatoshi Maki
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6315 (2020)
ALG-2 is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in mammalian cells. In order to find new ALG-2-binding partners, we searched a human protein database and retrieved sequences containing the previously identified
Externí odkaz:
https://doaj.org/article/deb9cba10808431d8d6a5a5e5882fb20
Autor:
Takeshi Takahashi, Kyosuke Kojima, Wei Zhang, Kanae Sasaki, Masaru Ito, Hironori Suzuki, Masato Kawasaki, Soichi Wakatsuki, Terunao Takahara, Hideki Shibata, Masatoshi Maki
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3677-3699 (2015)
ALG-2, a 22-kDa penta-EF-hand protein, is involved in cell death, signal transduction, membrane trafficking, etc., by interacting with various proteins in mammalian cells in a Ca2+-dependent manner. Most known ALG-2-interacting proteins contain proli
Externí odkaz:
https://doaj.org/article/e80f996aaaa6425b9078b2046e3d4ebb
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 605 (2018)
NFAT is a cytoplasm-localized hyper-phosphorylated transcription factor that is activated through dephosphorylation by calcineurin, a Ca2+/calmodulin-dependent phosphatase. A non-palindromic NFAT-response element (RE) found in the IL2 promoter region
Externí odkaz:
https://doaj.org/article/4f47e69a12264adea329f97808061c30
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 9, p 1401 (2016)
ALG-2 (gene name: PDCD6) is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in a Ca2+-dependent fashion. ALG-2 recognizes different types of identified motifs in Pro-rich regions by using different hydrophobic pockets, b
Externí odkaz:
https://doaj.org/article/e09d70b187c34371928a3930a6953dbf
Autor:
Wataru Nomura, Su-Ping Ng, Terunao Takahara, Tatsuya Maeda, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue
Publikováno v:
Journal of Cell Science. 135
Target of rapamycin (TOR) forms two distinct complexes, TORC1 and TORC2, to exert its essential functions in cellular growth and homeostasis. TORC1 signaling is regulated in response to nutrients such as amino acids and glucose; however, the mechanis