Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Teruna J. Siahaan"'
Publikováno v:
Life, Vol 14, Iss 11, p 1456 (2024)
Neurodegenerative brain diseases such as Alzheimer’s disease (AD), multiple sclerosis (MS), and Parkinson’s disease (PD) are difficult to treat. Unfortunately, many therapeutic agents for neurodegenerative disease only halt the progression of the
Externí odkaz:
https://doaj.org/article/eef57141558f4968aa9da9d05d1b0d77
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1545 (2024)
Background and Objectives: A novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH2, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase (RNAP) of Mycobacterium tuberculosis (MTB). This peptide inhibits RNA elongati
Externí odkaz:
https://doaj.org/article/ed3f3bc70b47477a96633f72aa10897d
Autor:
Kelly Schwinghamer, Teruna J. Siahaan
Publikováno v:
Journal of Nanotheranostics, Vol 4, Iss 4, Pp 463-479 (2023)
Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfor
Externí odkaz:
https://doaj.org/article/a7711658f87e49e580dfaf182ce604bd
Autor:
Mohammad Norouzi, Vinith Yathindranath, James A. Thliveris, Brian M. Kopec, Teruna J. Siahaan, Donald W. Miller
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of different tumors, its effectiveness in treating glioblastoma multiforme (GBM) is constrained by insufficient penetration across the blood–brain b
Externí odkaz:
https://doaj.org/article/48789dff986642a393532b6e887ac3be
Publikováno v:
Life, Vol 12, Iss 11, p 1774 (2022)
Mycobacterium tuberculosis (MTB) is the main source of tuberculosis (TB), one of the oldest known diseases in the human population. Despite the drug discovery efforts of past decades, TB is still one of the leading causes of mortality and claimed mor
Externí odkaz:
https://doaj.org/article/781faa3784164e2ea85df58ab2a305cf
Publikováno v:
Life, Vol 12, Iss 9, p 1333 (2022)
Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Although several established antitubercular drugs have been found, various factors obstruct efforts to combat this disease due to the existence of drug-resistance (DR) T
Externí odkaz:
https://doaj.org/article/67ea713ac9c343168392ed0fbf85acbf
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 568 (2019)
Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain. Previously, various molecules were delivered through the paracellular pathway of the BB
Externí odkaz:
https://doaj.org/article/9b00799caef84923b0000fec990ab487
Autor:
Babu V. Sajesh, Ngoc H. On, Refaat Omar, Samaa Alrushaid, Brian M. Kopec, Wei-Guang Wang, Han-Dong Sun, Ryan Lillico, Ted M. Lakowski, Teruna J. Siahaan, Neal M. Davies, Pema-Tenzin Puno, Magimairajan Issai Vanan, Donald W. Miller
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 481 (2019)
The blood-brain barrier (BBB) poses a major obstacle by preventing potential therapeutic agents from reaching their intended brain targets at sufficient concentrations. While transient disruption of the BBB has been used to enhance chemotherapeutic e
Externí odkaz:
https://doaj.org/article/25cc141381be4297a117030ee6ead52b
Autor:
Usman Sumo Friend Tambunan, Irwan Makagiansar, Mike Avery, Seetharama D.S. Jois, Ernawati Sinaga, Teruna J. Siahaan
Publikováno v:
Makara Seri Sains, Vol 08, Iss 1, Pp 25-34 (2004)
Rapid advances in combinatorial chemistry and molecular biology has influenced the discovery of many proteins, peptides and peptidomimetics as potential therapeutic agents. Unfortunately, the practical application of these potential drugs is often re
Externí odkaz:
https://doaj.org/article/4f9e99a56b6847e8b301985abb82dcc2
Autor:
Vinith, Yathindranath, Nura, Safa, Babu V, Sajesh, Kelly, Schwinghamer, Magimairajan Issai, Vanan, Rashid, Bux, Daniel S, Sitar, Marshall, Pitz, Teruna J, Siahaan, Donald W, Miller
Publikováno v:
Cancers. 14(21)
Spermidine/spermine N1-acetyltransferase 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e71f3b4f5380e7bcfb9c5ff9536dd95c
https://pubmed.ncbi.nlm.nih.gov/36358597
https://pubmed.ncbi.nlm.nih.gov/36358597