Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Terumasa Okada"'
Autor:
Franco Folli, Terumasa Okada, Carla Perego, Jenny Gunton, Chong Wee Liew, Masaru Akiyama, Anna D'Amico, Stefano La Rosa, Claudia Placidi, Roberto Lupi, Piero Marchetti, Giorgio Sesti, Marc Hellerstein, Lucia Perego, Rohit N Kulkarni
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28050 (2011)
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of isl
Externí odkaz:
https://doaj.org/article/23505363de844bbd8c545a0c63de5f09
Autor:
Siming Liu, Terumasa Okada, Anke Assmann, Jamie Soto, Chong Wee Liew, Heiko Bugger, Orian S Shirihai, E Dale Abel, Rohit N Kulkarni
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7983 (2009)
Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering complex in beta-cell
Externí odkaz:
https://doaj.org/article/59b2382dd2f54c28922b57d6ab0c18ec
Autor:
Kyoko Morikawa, Tomohiro Kasatani, Hiroyuki Yoshida, Hirofumi Uto, Masanori Yoshie, Masatora Iwashina, Akira Asano, Terumasa Okada, Hidetoshi Kanno
Publikováno v:
Diabetology International. 4:186-189
Aims We diagnosed gestational diabetes mellitus according to the criteria of the International Association of the Diabetes and Pregnancy Study Groups (IADPSG), treated gestational diabetes mothers in order to achieve normal glycemic levels, and evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49956927071fbd833eed5f267877d9bc
https://doi.org/10.1007/s13340-013-0114-2
https://doi.org/10.1007/s13340-013-0114-2
Autor:
C. Ronald Kahn, Rohit N. Kulkarni, Kim Cheng, Sun Hee Yim, Frank J. Gonzalez, James G. Kench, Sue Mei Lau, Philip J. O'Connell, Xiaohui L. Wang, Thomas Loudovaris, Terumasa Okada, Andrew V. Biankin, Jenny E. Gunton, Kenneth W. K. Ho, Thomas W.H. Kay, Rebecca A. Stokes, Wayne J. Hawthorne, Christopher Scott, Shane T. Grey, Yatrik M. Shah, D. Ross Laybutt
Publikováno v:
Journal of Clinical Investigation. 120:2171-2183
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1α protein are tightly regulated, recent studies suggest that it can be active under normoxic conditions. We hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57660ce5a1fc824f26445d307279b3a
https://doi.org/10.1172/jci35846
https://doi.org/10.1172/jci35846
Autor:
Martin Holzenberger, Rohit N. Kulkarni, Catherine Yin, Terumasa Okada, Chong Wee Liew, Charlotte Hinault, M. Dodson Michael, Jiang Hu, Jan Kr̈tzfeldt, Markus Stoffel
Publikováno v:
Proceedings of the National Academy of Sciences. 104:8977-8982
Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian tissues including pancreatic islets. To explore the specificity of insulin receptors in compensatory beta-cell growth, we exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e91b727c08ab70f38a3d98b03c72db3
https://doi.org/10.1073/pnas.0608703104
https://doi.org/10.1073/pnas.0608703104
Autor:
Gabriella M. Dahlgren, Robert T. Kennedy, Eleftheria Maratos-Flier, Siming Liu, Chong Wee Liew, Amarnath J. Kurpad, Umut Ozcan, Rohit N. Kulkarni, Pavlos Pissios, Efi Kokkotou, Jennifer N. Peters, Jason Karamchandani, Yogish C. Kudva, Terumasa Okada
Publikováno v:
Diabetes. 56:311-319
Melanin concentrating hormone (MCH) is a hypothalamic neuropeptide known to play a critical role in energy balance. We have previously reported that overexpression of MCH is associated with mild obesity. In addition, mice have substantial hyperinsuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304aa8272266274d1793ad61624adcd
https://doi.org/10.2337/db06-0708
https://doi.org/10.2337/db06-0708
Autor:
Terumasa Okada, Katrine Almind, C. Ronald Kahn, H. Joseph Goren, Kohjiro Ueki, Jonathon N. Winnay, Rohit N. Kulkarni
Publikováno v:
Diabetes. 52:1528-1534
Type 2 diabetes is a complex disease in which genetic and environmental factors interact to produce alterations in insulin action and insulin secretion, leading to hyperglycemia. To evaluate the influence of genetic background on development of diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d39b2475211e8e073d8e5fccb91c5e
https://doi.org/10.2337/diabetes.52.6.1528
https://doi.org/10.2337/diabetes.52.6.1528
Autor:
Kazuo Hara, Philippe Boutin, Yasumichi Mori, Kazuyuki Tobe, Christian Dina, Kazuki Yasuda, Toshimasa Yamauchi, Shuichi Otabe, Terumasa Okada, Kazuhiro Eto, Hiroko Kadowaki, Ryoko Hagura, Yasuo Akanuma, Yoshio Yazaki, Ryozo Nagai, Matsuo Taniyama, Koichi Matsubara, Madoka Yoda, Yasuko Nakano, Satoshi Kimura, Motowo Tomita, Chikako Ito, Philippe Froguel, Takashi Kadowaki
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2002, 51 (2), pp.536-40
Diabetes, American Diabetes Association, 2002, 51 (2), pp.536-40
An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the adiponectin gene (APM1) is located. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abc67bb6cd9dbe0edd585b8af6b2a62
https://doi.org/10.2337/diabetes.51.2.536
https://doi.org/10.2337/diabetes.51.2.536
Autor:
Terumasa Okada, Rohit N. Kulkarni
Publikováno v:
Endocrine. 19:257-266
The techniques to study the mechanisms that underlie the pathogenesis of disease processes have been revolutionized by the development of methods that allow spatiotemporal control of gene deletion or gene expression in transgenic and knockout animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a55f967460338a42e65a389bcc2679
https://doi.org/10.1385/endo:19:3:257
https://doi.org/10.1385/endo:19:3:257
Autor:
Kazuyuki Tobe, Yoshihiko Kawaguchi, Kazuki Yasuda, Kazuo Hara, Takashi Kadowaki, Terumasa Okada, Hiroshi Ikegami, C. Ito
Publikováno v:
Diabetologia. 44:241-244
Aims/hypothesis. Neurogenin 3 (ngn3) is a transcription factor expressed in the endocrine precursor cells of the pancreas. It has recently been reported that ngn3-deficient mice show absence of pancreatic endocrine cells and die of postnatal diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a51371ccc8e52b5e4a485c3a7a038b
https://doi.org/10.1007/s001250051606
https://doi.org/10.1007/s001250051606