Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Teruko Osumi"'
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3JC48-3 (methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth
Autor: Sanjeev Shukla, Steven Fletcher, Jay Chauhan, Victor Chalfant, Carlos Riveros, Yuri Mackeyev, Pankaj Kumar Singh, Sunil Krishnan, Teruko Osumi, K. C. Balaji
Publikováno v: Cancer Gene Therapy. 29:1550-1557
The proto-oncogene cellular myelocytomatosis (c-Myc) is a transcription factor that is upregulated in several human cancers. Therapeutic targeting of c-Myc remains a challenge because of a disordered protein tertiary structure. The basic helical stru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780ee9bbe54c2e276044c00f7934866c
https://doi.org/10.1038/s41417-022-00455-4
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3
Abstract 2475: Bromodomain inhibitor: MT1 and its potential role in modulation of prostate cancer progression
Autor: Sanjeev Shukla, Mohammed Al-Toubat, Allison H. Feibus, Ahmed Elshafei, Carlos Riveros, Nathalie Meurice, Justyna Gleba, Jonathan Chardon-Robles, Adam M. Kase, John A. Copland III, Joachim L. Petit, Teruko Osumi, K.C. Balaji
Publikováno v: Cancer Research. 83:2475-2475
Bromodomains (BD) are epigenetic readers of histone acetylation involved in chromatin remodeling and transcriptional regulation of protooncogene cellular myelocytomatosis (c- Myc) and other genes. Because c-Myc cannot be directly targeted by small mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5a72008e42ddd90f768d373e0014686
https://doi.org/10.1158/1538-7445.am2023-2475
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6
Abstract 1625: c-Myc inhibition in prostate cancer cell lines
Autor: Carlos Riveros, Victor Chalfant, Sanjeev Shukla, Teruko Osumi, KC Balaji
Publikováno v: Cancer Research. 82:1625-1625
The proto-oncogene c-Myc is a transcription factor that is upregulated in several human cancers. Despite its key role, therapeutic targeting of c-Myc remains a challenge because of a disordered protein tertiary structure. The basic helical structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d33b996dfadfc4f8ab7bb576b4dd6c3f
https://doi.org/10.1158/1538-7445.am2022-1625
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7
Abstract 1622: Signaling of cyclin-dependent kinase 12 (CDK12) in prostate cancer cell lines
Autor: Victor Chalfant, Carlos Riveros, Sanjeev Shukla, Teruko Osumi, K Balaji
Publikováno v: Cancer Research. 82:1622-1622
Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases. In contrast to CDKs which promote cell cycle progression, CDK12 is a transcriptional regulator of various cellular functions,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5762576612a3d9410b25420e638ddda5
https://doi.org/10.1158/1538-7445.am2022-1622
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8
3JC48-3: Novel MYC inhibition in advanced prostate cancer
Autor: Victor Chalfant, Carlos Riveros, Sanjeev Shukla, Teruko Osumi, KC Balaji
Publikováno v: Journal of Clinical Oncology. 40:181-181
181 Background: The proto-oncogene c-Myc is a transcription factor that is upregulated in several human cancers. Despite its key role, therapeutic targeting of c-Myc remains a challenge because of a disordered protein tertiary structure. The basic he
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a54e826868bf934022c0c3a1923c45
https://doi.org/10.1200/jco.2022.40.6_suppl.181
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